Invitrogen

Sortilin Monoclonal Antibody (CL6528)

Name: Sortilin Monoclonal Antibody (CL6528)
Brand: Invitrogen
SKU: MA5-31438

高级验证

1 篇参考文献

查看其他19个Sortilin抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (8)
高级验证 (1)

Sortilin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

图: 1 / 9

Sortilin Antibody (MA5-31438) in IHC (P)

Immunohistochemical analysis of Sortilin in mouse hippocampus using Sortilin Monoclonal Antibody (CL6528) (Product # MA5-31438) shows strong cytoplasmic positivity in both pyramidal neurons and granular cells.

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Immunogen image

Immunogen Image Sortilin Monoclonal Antibody (CL6528)

产品信息

MA5-31438

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1 µg/mL

查看1篇已发表文章 1篇已发表文章

免疫组化（石蜡） (IHC (P))

1:200-1:500

产品规格

种属反应

Human, Mouse

已发表种属

C. elegans

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

CL6528

抗原

Recombinant protein fragment of Human SORT1 (Product #RP-88683).

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_2787074

产品详细信息

Immunogen sequence: LERNCEEKDY TIWLAHSTDP EDYEDGCILG YKEQFLRLRK SSVCQNGRDY VVTKQPSICL CSLEDFLCDF GYYRPENDSK CVEQPELKGH DLEFCLYGRE EHLTTNGYRK IPGDKCQGGV NPVREVKD

Highest antigen sequence indentity to the following orthologs: Mouse - 89%, Rat - 89%.

靶标信息

Sortilin functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Sortilin is required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). It is also required for protein transport from the Golgi apparatus to the endosomes. Sortilin promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also, Sortilin acts as a receptor for neurotensin.

仅用于科研。不用于诊断过程。未经明确授权不得转售。