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Invitrogen
Stargazin Monoclonal Antibody (N245/36)
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图: 1 / 2
Stargazin Antibody (MA5-27645) in ICC/IF
Immunofluorescent analysis of Stargazin in human neuroblastoma cell line (SK-N-BE). Sample was fixed with 4% formaldehyde (15 min at RT), incubated with Stargazin monoclonal antibody (Product # MA5-27645) using a dilution of 1:100 (1 hour at RT), and followed by Goat Anti-Mouse 488, Phalloidin Texas Red and DAPI secondary antibody at a dilution of 1:100, 1:1000 (60 min at RT) and 1:5000 (5 min at RT). Image... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-27645
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
N245/36
抗原
Fusion protein amino acids 203-323 (Cytoplasmic C-terminus) of rat TARPGamma2
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein G
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
1 µg/mL of MA5-27645 was sufficient for detection of TARP Gamma2/4/8 in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.|Detects approximately 35-55kDa. Does not cross-react with TARPGamma3.
This antibody was formerly sold as clone S245-36.
靶标信息
Stargazin is a member of the transmembrane AMPAR regulatory proteins (TARP) family and is involved in glutamate receptor trafficking. It has been recently demonstrated that the interaction between stargazin and AMPA receptors is critical for the correct localization of the receptors at the synapse. Phosphorylation of the stargazin protein at Thr 321 by Protein Kinase A regulates its interaction with PSD-95 and synaptic targeting of AMPA receptors.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CACNG2; calcium channel, voltage-dependent, gamma subunit 2; CaV gamma 2; MGC123981; MGC138502; MGC138504; neuronal voltage-gated calcium channel gamma-2 subunit; regulatory subunit; stargazin; TARP; TARP gamma-2; transmembrane AMPAR regulatory protein gamma-2; unnamed protein product
基因别名: B230105C07Rik; B930041E13Rik; Ipr328; MRD10; stargazer; stargazin; stg; wag; waggler
UniProt ID: (Human) Q9Y698, (Mouse) O88602, (Rat) Q71RJ2
Entrez Gene ID: (Human) 10369, (Mouse) 12300, (Rat) 84347
protein targeting to membrane
calcium ion transport
transmission of nerve impulse
response to calcium ion
positive regulation of synaptic transmission, glutamatergic
eye blink reflex
calcium ion transmembrane transport
postsynaptic neurotransmitter receptor diffusion trapping
regulation of postsynaptic membrane neurotransmitter receptor levels
neurotransmitter receptor localization to postsynaptic specialization membrane
positive regulation of protein localization to basolateral plasma membrane
regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
neuromuscular junction development
regulation of membrane potential
neurological system process
membrane depolarization
membrane hyperpolarization
positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
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