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Alomone Labs, LTD
SynGAP Polyclonal Antibody
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SynGAP Antibody (APZ-032-200UL) in IHC (F)
Expression of SynGAP in mouse globus pallidus and rat lateral septum - Immunohistochemical staining of perfusion-fixed frozen mouse and rat brain sections using Anti-SynGAP Antibody (#APZ-032), (1:200), followed by goat- Anti-rabbit-AlexaFluor-488. A. SynGAP staining (green) in mouse brain is detected in neuropil (arrows) in the globus pallidus (GP) that is markedly stronger than in the striatum. B. SynGAP ... View More
产品信息
APZ-032-200UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)KSMDESRLDRVKEYE, corresponding to amino acid residues 1185-1199 of rat SynGAP, C-terminus
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
Synaptic Ras-GTPase activating protein (SynGAP) is a PDZ-domain interacting protein expressed almost exclusively in the brain. SynGAP has been shown to be a major component of postsynaptic density and associates with post synaptic density 95 kDa (PSD-95), a synaptic scaffold protein, and synaptic N-methyl-D-aspartate (NMDA) receptors. SynGAP Ras-GTPase activity has also been shown to be inhibited by phosphorylation by CaM kinase II, another abundant protein located in the postsynaptic density. It has been proposed that SynGAP may function as a negative regulator of MAP Kinase activation in the absence of active NMDA receptors.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DKFZp761G1421; Neuronal R; Neuronal RasGAP; OTTHUMP00000209046; p135 SynGAP; Ras GTPase-activating protein SynGAP; Ras/Rap GTPase-activating protein SynGAP; synaptic Ras GTPase activating protein 1 homolog; synaptic Ras GTPase activating protein, 135kDa; Synaptic Ras GTPase-activating protein 1; Synaptic Ras-GAP 1
基因别名: Gm1963; KIAA1938; MRD5; RASA1; RASA5; SYNGAP; SYNGAP1
UniProt ID: (Human) Q96PV0, (Mouse) F6SEU4
Entrez Gene ID: (Human) 8831, (Rat) 192117, (Mouse) 240057
MAPK cascade
Ras protein signal transduction
pattern specification process
visual learning
dendrite development
receptor clustering
regulation of MAPK cascade
negative regulation of neuron apoptotic process
positive regulation of GTPase activity
negative regulation of Ras protein signal transduction
regulation of synaptic plasticity
regulation of long-term neuronal synaptic plasticity
negative regulation of axonogenesis
signal transduction
regulation of synapse structure or activity
regulation of GTPase activity
