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NeoBiotechnologies
Synaptophysin (Neuroendocrine Marker) Recombinant Rabbit Monoclonal Antibody (MSVA-462R)
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产品信息
6855-RBM25-P1
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
MSVA-462R
抗原
Recombinant fragment (around aa 274-313) of human Synaptophysin (SYP) protein (exact sequence is proprietary).
偶联物
形式
Liquid
浓度
200 µg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS with 0.05% BSA
内含物
0.05% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product cellular localization: Cell membrane, Cytoplasm.
Positive control: Human adrenal gland or ovary. HeLa, HEK293T or SiHa cells.
Tissue specificity: Predominantly expressed in liver, lung, heart and placenta. Lower levels in pancreas, kidney, skeletal muscle and brain. Overexpressed in multiple myeloma cells. Highly expressed during B-cell development, from pro-B precursors to plasma cells. Highly expressed on T-cells, monocytes, NK cells and dendritic cells (at protein level).
靶标信息
Synaptophysin is a calcium-binding and integral membrane glycoprotein present in presynaptic vesicles in almost all neurons. Synaptophysin has four transmembrane domains and it forms a complex with dynamin at high calcium concentrations suggesting an involvement in synaptic vesicle endocytosis. It is also involved in the regulation of short-term and long-term synaptic plasticity. Synaptophysin is currently the most widely used marker for nerve terminals and for differentiating neuroendocrine tumors. Mutations in the gene can result in mental retardation, X-linked 96.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Major synaptic vesicle protein p38; Synaptophysin; unnamed protein product
基因别名: MRX96; MRXSYP; SYP; XLID96
UniProt ID: (Human) P08247
Entrez Gene ID: (Human) 6855
endocytosis
regulation of synaptic vesicle priming
synaptic vesicle maturation
regulation of neuronal synaptic plasticity
regulation of long-term neuronal synaptic plasticity
regulation of short-term neuronal synaptic plasticity
synaptic vesicle membrane organization
modulation of synaptic transmission
regulation of opioid receptor signaling pathway
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