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Invitrogen
Synaptotagmin 1 Recombinant Rabbit Monoclonal Antibody (HL1654)
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Synaptotagmin 1 Antibody (MA5-47124) in WB
Western blot analysis of Synaptotagmin 1 in Various whole cell extracts (30 µg) separated by 10% SDS-PAGE. Membrane was blotted with Synaptotagmin 1 Monoclonal antibody (Product # MA5-47124) using a dilution of 1:1,000 followed by HRP-conjugated anti-rabbit IgG secondary antibody. Corresponding RNA expression data for the same cell lines are based on Human Protein Atlas program.
产品信息
MA5-47124
产品规格
种属反应
Fruit fly,
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
HL1654
抗原
Recombinant fragment of human Synaptotagmin 1
偶联物
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Store as concentrated solution.
Centrifuge briefly prior to opening vial.
靶标信息
Synaptotagmin 1 is a synaptic vesicle membrane glycoprotein that is widely expressed throughout the CNS and is generally thought to act as the Ca2+ sensor in the regulation of exocytosis and neurotransmitter release. Studies indicate that synaptotagmin's Ca2+ mediated binding of SNAP25 is essential for the Ca2+ dependent triggering of membrane. It has been demonstrated that discrete residues within the c(2)b binding domain of synaptotagmin 1 independently specify endocytic rate and synaptic vesicle size. Synaptotagmin 1 may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. Further, Synaptotagmin 1 binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has been reported. Synaptotagmin 1 can also bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Diseases associated with the dysfunction of Synaptotagmin 1 include food-borne botulism and infant botulism.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CG3139-PA; CG3139-PB; CG3139-PC; CG3139-PE; CG3139-PF; CG3139-PG; CG3139-PH; CG3139-PI; DKFZp781D2042; FLJ42519; p65; SV DKFZp781D2042; SV SYT; Syb1; synaptoptagmin 1; synaptotagmin; Synaptotagmin 1; synaptotagmin 2; Synaptotagmin I; Synaptotagmin II; Synaptotagmin XI; Synaptotagmin-1; Synaptotagmin-2; Synaptotagmin-I; Synaptotagmin1; SynaptotagminI; Syt I; Syt1-PA; Syt1-PB; Syt1-PC; Syt1-PE; Syt1-PF; Syt1-PG; Syt1-PH; Syt1-PI; SYT2; SytI; SytII; unnamed protein product
基因别名: AW124717; BAGOS; CG3139; D. Syt I; Dmel\CG3139; Dmel_CG3139; Droso1; DSypt; DSypt1; DSYT; DSYT1; DSYT2; dsytI; G630098F17Rik; l(2)23AB1; l(2)23Ba; l(2)k05909; P65; STY1; SVP65; syn; SYT; Syt 1; SYT I; Syt-1; SYT1; SytI
UniProt ID: (Human) P21579, (Rat) P21707, (Mouse) P46096, (Fruit fly) P21521
Entrez Gene ID: (Human) 6857, (Rat) 25716, (Mouse) 20979, (Fruit fly) 33473
SNARE binding
phosphatidylserine binding
calcium ion binding
protein binding
calmodulin binding
phospholipid binding
calcium-dependent phospholipid binding
phosphatidylinositol-4,5-bisphosphate binding
lipid binding
syntaxin-1 binding
syntaxin binding
clathrin binding
syntaxin-3 binding
identical protein binding
metal ion binding
protein heterodimerization activity
calcium-dependent protein binding
low-density lipoprotein particle receptor binding
calcium ion sensor activity
molecular condensate scaffold activity
transporter activity
protein C-terminus binding
protein homodimerization activity
membrane trafficking regulatory protein
detection of calcium ion
vesicle fusion
chemical synaptic transmission
neurotransmitter secretion
regulation of dopamine secretion
vesicle organization
synaptic vesicle exocytosis
vesicle-mediated transport
regulation of exocytosis
regulation of calcium ion-dependent exocytosis
cell differentiation
regulation of vesicle fusion
positive regulation of vesicle fusion
positive regulation of dopamine secretion
positive regulation of calcium ion-dependent exocytosis
vesicle docking
calcium ion-regulated exocytosis of neurotransmitter
positive regulation of synaptic transmission
protein heterooligomerization
response to calcium ion
regulation of synaptic transmission, glutamatergic
spontaneous neurotransmitter secretion
cellular response to calcium ion
synchronous neurotransmitter secretion
fast, calcium ion-dependent exocytosis of neurotransmitter
calcium-dependent activation of synaptic vesicle fusion
membraneless organelle assembly
positive regulation of calcium ion-dependent exocytosis of neurotransmitter
regulation of regulated secretory pathway
positive regulation of dendrite extension
regulation of synaptic vesicle exocytosis
calcium ion regulated exocytosis
synaptic vesicle endocytosis
regulation of pole plasm oskar mRNA localization
larval locomotory behavior
regulation of synapse structure or activity
rhythmic synaptic transmission
clathrin-dependent synaptic vesicle endocytosis
regulation of neuromuscular synaptic transmission
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