Invitrogen

Syntaphilin Polyclonal Antibody

Name: Syntaphilin Polyclonal Antibody
Brand: Invitrogen
SKU: PA5-20528
Availability: InStock

查看其他9个Syntaphilin抗体

说明书

Certificates

实验方案

问题与答案

技术支持

说明书

Certificates

实验方案

问题与答案

技术支持

说明书

Certificates

实验方案

问题与答案

技术支持

Additional Information:

抗体检测数据 (3)

Syntaphilin Antibody in Immunocytochemistry (ICC/IF)

图: 1 / 3

Syntaphilin Antibody (PA5-20528) in ICC/IF

Immunofluorescence of Syntaphilin in Human Brain cells with Syntaphilin Polyclonal Antibody (Product # PA5-20528) at 20 µg/mL.

Syntaphilin Antibody in Immunohistochemistry (IHC)

Syntaphilin Antibody in Western Blot (WB)

Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.

Product Image Gallery

Immunogen image

Immunogen Image Syntaphilin Polyclonal Antibody

产品信息

PA5-20528

应用

建议稀释比

已发表文章

免疫印迹 (WB)

2-4 µg/mL

免疫组化 (IHC)

5 µg/mL

免疫细胞化学 (ICC/IF)

20 µg/mL

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

An 18 amino acid peptide from near the amino terminus of human Syntaphilin.

3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

100 µg

纯化类型

Antigen affinity chromatography

保存液

PBS

内含物

0.02% sodium azide

保存条件

Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C

运输条件

Ambient (domestic); Wet ice (international)

AB_11152367

产品详细信息

Despite its predicted molecular weight, Syntaphilin often migrates at a higher molecular weight in SDS-PAGE. A suggested positive control is human brain tissue lysate.

PA5-20528 can be used with blocking peptide PEP-0648.

靶标信息

Syntaphilin was initially identified in a yeast two-hybrid screen with the carboxy terminal region of Syntaxin-1 as bait. Syntaxin-1 is a key component of the synaptic vesicle docking machinery that forms the SNARE complex with synaptobrevin and SNAP-25. Syntaphilin competes with SNAP-25 for binding to syntaxin-1 and inhibits the formation of the SNARE complex, thereby potentially regulating synaptic vesicle exocytosis. Syntaphilin also binds dynamin-1 and inhibits dynamin-dependent endocytosis. Mice lacking syntaphilin show an increased level of mitochondrial motility and a reduced density of axonal mitochondria. This correlates with an enhanced short-term facilitation and significant impairments in motor ability, suggesting syntaphilin plays a major role in presynaptic function. Multiple isoforms are known to exist.

仅用于科研。不用于诊断过程。未经明确授权不得转售。