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Positive Samples: 293T
Immunogen sequence: MSLQVLNDKN VSNEKNTENC DFLFSPPEVT GRSSVLRVSQ KENVPPKNLA KAMKVTFQTP LRDPQTHRIL SPSMASKLEA PFTQDDTLGL ENSHPVWTQK
TACC1 is located on 8p11 chromosomal region that is amplified in approximately 15% of all breast tumor samples. The short arm of chromosome 8 also contains FGFR1 whose expression is enhanced in most breast cancer tumors. TACC family members, TACC1, TACC2, and TACC3, map very closely to the corresponding FGFR1, FGFR2, FGFR3 genes on chromosomes 4,8, and 10. Subsequently, since they are phylogenetically related, it is proposed that TACC and FGFR have similar roles in cell growth and differentiation. Also, TACC1 contains a conserved C-terminal region as in the Drosophila homolog, D-TACC. It has been shown that D-TACC is necessary for normal spindle function, and the mammalian TACC proteins appears to interact with centrosomes and microtubules in a similar manner.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Arnt interacting protein; ARNT-interacting protein; ERIC-1; transforming acidic coiled coil 3; Transforming acidic coiled-coil-containing protein 3; transforming, acidic coiled-coil containing protein 3
基因别名: Aint; C86661; ERIC-1; ERIC1; TACC3
UniProt ID: (Human) Q9Y6A5
Entrez Gene ID: (Human) 10460, (Mouse) 21335, (Rat) 360962