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Invitrogen
TADA3L Polyclonal Antibody
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产品信息
PA5-96535
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 270-369 of human TADA3 (NP_5978141)
偶联物
形式
Liquid
浓度
0.59 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: EENIISPMED SPIPDMSGKE SGADGASTSP RNQNKPFSVP HTKSLESRIK EELIAQGLLE SEDRPAEDSE DEVLAELRKR QAELKALSAH NRTKKHDLLR; Positive Samples: HT-29, BxPC-3, HepG2, HeLa, Mouse testis, Mouse liver, Rat testis, Rat liver; Cellular Location: Nucleus
靶标信息
Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. In addition, it associates with the tumor suppressor protein p53 and is required for full activity of p53 and p53-mediated apoptosis. At least four alternatively spliced variants have been found for this gene, but the full-length nature of some variants has not been determined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ADA3 homolog; ADA3-like protein; alteration/deficiency in activation 3; FLJ20221; FLJ21329; hADA3; mADA3; STAF54; Transcriptional adapter 3; Transcriptional adapter 3-like
基因别名: 1110004B19Rik; ADA3; AI987856; hADA3; NGG1; STAF54; TADA3; TADA3L
UniProt ID: (Human) O75528, (Rat) Q4V8F5, (Mouse) Q8R0L9
Entrez Gene ID: (Human) 10474, (Rat) 362414, (Mouse) 101206
transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
histone acetyltransferase activity
protein binding
ligand-dependent nuclear receptor binding
protein domain specific binding
ligand-dependent nuclear receptor transcription coactivator activity
chromatin/chromatin-binding, or -regulatory protein
histone modifying enzyme
regulation of protein phosphorylation
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
mitotic nuclear division
positive regulation of gene expression
intracellular estrogen receptor signaling pathway
regulation of histone deacetylation
regulation of protein stability
histone H3 acetylation
positive regulation of transcription, DNA-templated
regulation of tubulin deacetylation
biological_process
regulation of nucleic acid-templated transcription
regulation of transcription, DNA-templated
