Invitrogen

TAOK1 Polyclonal Antibody

Name: TAOK1 Polyclonal Antibody
Brand: Invitrogen
SKU: PA5-34250

查看其他13个TAOK1抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (8)

TAOK1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

图: 1 / 8

TAOK1 Antibody (PA5-34250) in IHC (P)

Immunohistochemistry analysis of TAOK1 in human Brain, Glioblastoma. Samples were incubated with TAOK1 polyclonal antibody (Product # PA5-34250). Formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

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产品信息

PA5-34250

应用

建议稀释比

已发表文章

免疫组化（石蜡） (IHC (P))

4.4 µg/mL

产品规格

种属反应

Bat, Bovine, Dog, Horse, Hamster, Human, Mouse, Non-human primate, Pig, Rabbit, Rat, Xenopus

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic 16 amino acid peptide from internal region of human TAOK1.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS

内含物

0.1% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_2551602

靶标信息

TAOK1 is a serine/threonine-protein kinase involved in regulation of the p38-containing stress-responsive MAP kinase pathway and extracellular signal-regulated protein kinase (ERK) kinases (MEKs). The activation of and binding to MEK3 by TAOK1 implicates TAOK1 in the regulation of the p38-containing stress-responsive MAP kinase pathway. A microtubule affinity-regulating kinase, TAOK1 (also known as MARKK) is an important regulator of mitotic progression, required for both chromosome congression and checkpoint-induced anaphase delay. TAOK1 is involved in various processes such as p38/MAPK14 stress-activated MAPK cascase, DNA damage response, and regulations of cytoskeleton stability. It phosphorylates MAP2K3, MAP2K6, and MARK2. TAOK1 acts as an activator of the p38/MAPK cascade by mediating phosphorylation and subsequent activation of the upsteam MAP2K3 and MAP2K6 kinases. It is involved in G-protein couples receptor signaling to p38/MAPK14. In response to DNA damage, TAOK1, is involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade by phosphorylaton of MAP2K3 and MAP2K6. In addition, it acts as a regulator of cytoskeleton stability and a regulator of apoptosis.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: FLJ14314; h hTAOK1; H KIAA1361; hKFC-B; Kinase from chicken homolog B; MARK Kinase; MARKK; microtubule affinity regulating kinase kinase; prostate-derived STE20-like kinase 2; Prostate-derived sterile 20-like kinase 2; PSK-2; serine/threonine protein kinase TAO1; serine/threonine protein kinase TAO1 homolog; Serine/threonine-protein kinase TAO1; Serine/threonine-protein kinase TAO1-like protein; STE20-like kinase PSK2; tao; TAO kinase 1; TAOK1; Thousand and one amino acid protein 1; Thousand and one amino acid protein kinase 1

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基因别名: 2810468K05Rik; AU020252; D130018F14Rik; hKFC-B; hTAOK1; I79_013371; KFC-B; KIAA1361; MAP3K16; MARKK; mKIAA1361; PSK-2; PSK2; TAO1; TAOK1

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UniProt ID: (Human) Q7L7X3, (Mouse) Q5F2E8, (Rat) O88664