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Invitrogen
TAOK2 Polyclonal Antibody
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TAOK2 Antibody (PA5-29249) in ICC/IF
TAOK2 Polyclonal Antibody detects TAOK2 protein at cytoplasm and nucleus by immunofluorescent analysis. Sample: HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: TAOK2 protein stained by TAOK2 Polyclonal Antibody (Product # PA5-29249) diluted at 1:500. Blue: Hoechst 33343 staining.
产品信息
PA5-29249
产品规格
种属反应
Mouse,
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the N-terminus region of human TAOK2. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 10% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recommended positive controls: mouse brain.
Predicted reactivity: Mouse (99%), Rat (99%), Xenopus laevis (93%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
TAOK2 (TAO1) is a serine/threonine kinase that may be an important regulator of the stress-responsive p38 MAP kinase pathway. In vitro, TAO (thousand and one amino acid) protein kinase 2 (TAO2) activates MAP/ERK kinases (MEK ) 3, 4, and 6 toward their substrates p38 MAP kinase JNK/SAPK (Chen et al., 1999; Chen and Cobb, 2001). This and more recent work has led to the proposal that the TAO protein kinases play an essential role in signaling from physiological agonist to the stress -responsive p38 MAPK (Chen et al., 2003). Autophosphorylation of TAO may play a role in the mechanism of TAO activation. The MEK binding domain of TAO is autophosphorylated on both serine and threonine residues and Ser181 is located within this domain.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: hKFC-C; Kinase from chicken homolog C; prostate derived STE20-like kinase PSK; prostate-derived STE20-like kinase 1; Prostate-derived sterile 20-like kinase 1; PSK-1; Serine/threonine-protein kinase TAO2; tao; TAO kinase 2TAO kinase 2; Thousand and one amino acid protein 2; Thousand and one amino acid protein kinase 2
基因别名: 1110033K02Rik; B230344N16; KIAA0881; MAP3K17; mKIAA0881; PSK; PSK1; PSK1-BETA; TAO1; TAO2; TAOK2; UNQ2971/PRO7431
UniProt ID: (Human) Q9UL54, (Mouse) Q6ZQ29
Entrez Gene ID: (Human) 9344, (Mouse) 381921
protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
ATP binding
mitogen-activated protein kinase kinase binding
nucleotide binding
protein kinase activity
MAP kinase kinase kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
activation of MAPKK activity
regulation of cell growth
protein targeting to membrane
apoptotic process
response to stress
cellular response to DNA damage stimulus
regulation of cell shape
cell migration
actin cytoskeleton organization
G2 DNA damage checkpoint
positive regulation of stress-activated MAPK cascade
positive regulation of JNK cascade
focal adhesion assembly
stress-activated MAPK cascade
MAPK cascade
protein phosphorylation
regulation of mitotic cell cycle
phosphorylation
signal transduction by protein phosphorylation
stress-activated protein kinase signaling cascade
regulation of apoptotic process
