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Abnova
TAOK2 Monoclonal Antibody (3E2)
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产品信息
H00009344-M10
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
3E2
抗原
TAOK2 (AAH51798, 831 a.a. approximately 930 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
0.32 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Sandwich ELISA (Recombinant protein).
Immunogen sequence: ELQCRQYKRK MLLARHSLDQ DLLREDLNKK QTQKDLECAL LLRQHEATRE LELRQLQAVQ RTRAELTRLQ HQTELGNQLE YNKRREQELR QKHAAQVRQQ
靶标信息
TAOK2 (TAO1) is a serine/threonine kinase that may be an important regulator of the stress-responsive p38 MAP kinase pathway. In vitro, TAO (thousand and one amino acid) protein kinase 2 (TAO2) activates MAP/ERK kinases (MEK ) 3, 4, and 6 toward their substrates p38 MAP kinase JNK/SAPK (Chen et al., 1999; Chen and Cobb, 2001). This and more recent work has led to the proposal that the TAO protein kinases play an essential role in signaling from physiological agonist to the stress -responsive p38 MAPK (Chen et al., 2003). Autophosphorylation of TAO may play a role in the mechanism of TAO activation. The MEK binding domain of TAO is autophosphorylated on both serine and threonine residues and Ser181 is located within this domain.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: hKFC-C; Kinase from chicken homolog C; prostate derived STE20-like kinase PSK; prostate-derived STE20-like kinase 1; Prostate-derived sterile 20-like kinase 1; PSK-1; Serine/threonine-protein kinase TAO2; tao; Thousand and one amino acid protein kinase 2
基因别名: KIAA0881; MAP3K17; PSK; PSK1; PSK1-BETA; TAO1; TAO2; TAOK2; UNQ2971/PRO7431
UniProt ID: (Human) Q9UL54
Entrez Gene ID: (Human) 9344
activation of MAPKK activity
regulation of cell growth
protein targeting to membrane
apoptotic process
response to stress
cellular response to DNA damage stimulus
regulation of cell shape
cell migration
actin cytoskeleton organization
G2 DNA damage checkpoint
positive regulation of stress-activated MAPK cascade
positive regulation of JNK cascade
focal adhesion assembly
stress-activated MAPK cascade
