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Abnova
TAX1BP1 Monoclonal Antibody (2C3)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
H00008887-M01
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
2C3
抗原
TAX1BP1 (NP_006015, 690 a.a. approximately 789 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Cell lysate).
Immunogen sequence: DSEDSKEDEN VPTAPDPPSQ HLRGHGTGFC FDSSFDVHKK CPLCELMFPP NYDQSKFEEH VESHWKVCPM CSEQFPPDYD QQVFERHVQT HFDQNVLNFD
靶标信息
This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Tax1 (human T-cell leukemia virus type I) binding protein 1; TAX1BP1; TRAF6-binding protein; unnamed protein product
基因别名: CALCOCO3; T6BP; TXBP151
UniProt ID: (Human) Q86VP1
Entrez Gene ID: (Human) 8887
negative regulation of tumor necrosis factor-mediated signaling pathway
negative regulation of toll-like receptor 4 signaling pathway
negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway
negative regulation of apoptotic process
negative regulation of I-kappaB kinase/NF-kappaB signaling
protein localization to phagocytic vesicle
negative regulation of interleukin-1-mediated signaling pathway
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