Invitrogen

TBX1 Polyclonal Antibody

4个已发表图片
9 篇参考文献
查看其他6个TBX1抗体

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说明书
实验方案
问题与答案
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说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持

产品信息

34-9800

应用
建议稀释比
已发表文章

免疫印迹 (WB)

Assay-dependent
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免疫组化 (IHC)

-
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免疫组化（石蜡） (IHC (P))

1:20
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免疫沉淀 (IP)

Assay-dependent
查看1篇已发表文章 1篇已发表文章

染色质免疫沉淀 实验 (ChIP)

-
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产品规格

种属反应

Mouse

已发表种属

C. elegans, Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide derived from the internal region of the mouse T-box 1 (Tbx1) protein.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.25 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4

内含物

0.1% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2533191

靶标信息

TBX1 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product shares 98% amino acid sequence identity with the mouse ortholog. DiGeorge syndrome (DGS)/velocardiofacial syndrome (VCFS), a common congenital disorder characterized by neural-crest-related developmental defects, has been associated with deletions of chromosome 22q11.2, where this gene has been mapped. Studies using mouse models of DiGeorge syndrome suggest a major role for this gene in the molecular etiology of DGS/VCFS. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: T-box protein 1; T-box transcription factor TBX1; Testis-specific T-box protein

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基因别名: Tbx1

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UniProt ID: (Mouse) P70323

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Entrez Gene ID: (Mouse) 21380

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功能
RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding protein homodimerization activity sequence-specific DNA binding Rel homology transcription factor
参与通路
negative regulation of transcription from RNA polymerase II promoter angiogenesis blood vessel development patterning of blood vessels cell fate specification neural crest cell migration positive regulation of protein phosphorylation lymph vessel development blood vessel remodeling positive regulation of mesenchymal cell proliferation heart morphogenesis outflow tract septum morphogenesis outflow tract morphogenesis transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter multicellular organism development determination of left/right symmetry pattern specification process mesoderm development heart development muscle organ development sensory perception of sound cell proliferation positive regulation of cell proliferation anterior/posterior pattern specification vagus nerve morphogenesis epithelial cell differentiation thyroid gland development social behavior aorta morphogenesis ear morphogenesis inner ear morphogenesis outer ear morphogenesis middle ear morphogenesis odontogenesis of dentin-containing tooth muscle cell fate commitment positive regulation of MAPK cascade tongue morphogenesis cellular response to fibroblast growth factor stimulus negative regulation of cell differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter retinoic acid receptor signaling pathway blood vessel morphogenesis thymus development muscle organ morphogenesis embryonic cranial skeleton morphogenesis embryonic viscerocranium morphogenesis semicircular canal morphogenesis artery morphogenesis positive regulation of epithelial cell proliferation parathyroid gland development soft palate development pharyngeal system development face morphogenesis muscle tissue morphogenesis coronary artery morphogenesis enamel mineralization otic vesicle morphogenesis positive regulation of secondary heart field cardioblast proliferation cochlea morphogenesis mesenchymal cell apoptotic process regulation of organ morphogenesis positive regulation of tongue muscle cell differentiation negative regulation of mesenchymal cell apoptotic process
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