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Invitrogen
TCEB1 Polyclonal Antibody
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产品信息
PA5-67489
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
偶联物
形式
Liquid
浓度
0.4 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: ETNEVNFREIP SHVLSKVCMY FTYKVRYTNS STEI
Highest antigen sequence identity to the following orthologs - mouse 100%, rat 100%.
靶标信息
TCEB1 is known as protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: EloC; Elongin 15 kDa subunit; elongin C; Elongin-C; RNA polymerase II transcription factor SIII subunit C; SIII p15; transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C); Transcription elongation factor B polypeptide 1
基因别名: ELOC; SIII; TCEB1
UniProt ID: (Human) Q15369
Entrez Gene ID: (Human) 6921
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
transcription elongation from RNA polymerase II promoter
viral process
positive regulation of transcription elongation from RNA polymerase II promoter
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
regulation of transcription from RNA polymerase II promoter in response to hypoxia
