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Invitrogen
TCF12 Polyclonal Antibody
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TCF12 Antibody (PA5-78193) in WB
Western blot was performed using Anti-TCF12 Polyclonal Antibody) (Product # PA5-78193) and a 80 kDa band corresponding to TCF12 was observed in all tested cell lysates, and was down regulated upon neural differentiation of NSCs. Modified whole cell lysates (1% SDS) (30 µg lysate) of HeLa (Lane 1), LNCaP (Lane 2), MCF7 (Lane 3), Neural Stem Cells (Lane 4), and Neural Stem cells (Neural differentiation) (Lane 5) were electrophoresed using NuPAGE® 10 % Bis-Tris gel (Product # NP0302BOX). Resolved proteins were then transferred onto a nitrocel... View More
产品信息
PA5-78193
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the center region of human TCF12. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 1% BSA, 20% glycerol
内含物
0.025% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Control: Jurkat, Jurkat nuclear extract
Predicted Reactivity: Mouse (89%), Rat (88%), Bovine (97%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
TCF12, also known as HTF4, is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. TCF12 is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. TCF12, in combination with E2A, is required to block thymocyte proliferation prior to pre-TCR expression and is critical for proper T cell differentiation. Recent reports have shown that TCF12 is also a critical factor required for the development of invariant natural killer T cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: bHLHb20; Class B basic helix-loop-helix protein 20; DNA-binding protein HTF4; E-box-binding protein; helix-loop-helix transcription factor 4; TCF-12; Transcription factor 12; Transcription factor HTF-4
基因别名: BHLHB20; CRS3; HEB; HsT17266; HTF4; TCF-12; TCF12
UniProt ID: (Human) Q99081
Entrez Gene ID: (Human) 6938
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
enhancer binding
cAMP response element binding
protein homodimerization activity
bHLH transcription factor binding
transcription regulatory region DNA binding
SMAD binding
protein heterodimerization activity
E-box binding
HMG box domain binding
basic helix-loop-helix transcription factor
