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Immunogen sequence: MGSMFRSEEV ALVQLFLPTA AAYTCVSRLG ELGLVEFRDL NASVSAFQRR FVVDVRRCEE LEKTFTFLQE EVRRAGLVLP PPKGRLPAPP PRDLLRIQEE TERLAQELRD VRGNQQALRA QLHQLQLHAA; Positive Samples: U2OS, A-549, BxPC-3, U-937, HL-60, Mouse thymus, Mouse skeletal muscle, Rat thymus, Rat skeletal muscle; Cellular Location: Membrane, Multi-pass membrane protein
The T-cell immune regulator 1 (TCIRG1) is the a3 subunit of the vacuolar-type proton transporting ATPase (V-ATPase), a proton pump in late endosomes and lysosomes that functions in the luminal acidification of these organelles. Genetic defects in the gene encoding this protein a responsible for a severe form of autosomal recessive osteopetrosis, a condition that leads to increased bone density, decreased bone strength, and inflammation in bone tissues. TCIRG1 is also required for the normal secretion of insulin and the bacteria-killing function of macrophages.
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仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: ATPase, H+ transporting, 116kD; ATPase, H+ transporting, lysosomal I; ATPase, H+ transporting, lysosomal V0 protein a; OC-116 kDa; osteoclastic proton pump; Osteoclastic proton pump 116 kDa subunit; osteosclerotic; specific 116-kDa vacuolar proton pump subunit; T cell immune response cDNA7 protein; T-cell immune regulator 1; T-cell immune response cDNA 7; T-cell immune response cDNA7 protein; T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein a; T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3; T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3; TIRC7; V-ATPase 116 kDa subunit a 3; V-ATPase 116-kDa; V-ATPase a3; v-H+ATPase subunit a3; V-type proton ATPase 116 kDa subunit a; V-type proton ATPase 116 kDa subunit a 3; V-type proton ATPase 116 kDa subunit a isoform 3; vacuolar proton translocating ATPase 116 kDa subunit A; Vacuolar proton translocating ATPase 116 kDa subunit a isoform 3
基因别名: a3; ATP6a3; Atp6i; ATP6N1C; ATP6V0A3; oc; OC-116; OC-116kDa; OC116; OPTB1; Stv1; TCIRG1; TIRC7; Vph1
UniProt ID: (Human) Q13488
Entrez Gene ID: (Human) 10312, (Rat) 293650, (Mouse) 27060
分子生物学功能:
ATP synthase