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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Immunogen sequence: DMALHYANKY NIMLVRLNSK WDLRRLCKTV GATALPRLTP PVLEEMGHCD SVYLSEVGDT QVVVFKHEKE DGAISTIVLR GSTDNLMDDI ERAVDDGVNT FKVLTRDKRL VPGGGATEIE LAKQITSYGE TCPGLEQYAI KKFAEAFEAI PRALAENSGV KANEVISKLY AVHQEGNKNV GLDIEAEVPA VKDMLEAGIL DTYLGKYWAI KLATNAAVTV LRVDQIIMAK PAGGPKPPSG KKDWDDDQND; Positive Samples: B cells, LO2, 293T, HeLa, Mouse brain, Mouse liver, Mouse lung, Rat brain; Cellular Location: Cytoplasm, centrosome, cilium basal body, cytoskeleton, microtubule organizing center
TCP-1 theta is theta subunit of the CCT (chaperonin containing TCP1 complex) chaperonin molecule which is abundant in the eukaryotic cytosol and may be involved in the transport and assembly of the newly synthesized proteins. Molecular chaperones assist in the protein folding upon ATP hydrolysis and TCP-1 theta may play a role in the assembly of the BBsome, a complex that is involved in ciliogenesis regulating transport vesicles to the cilia. Further, TCP-1 theta is also involved in the folding of actin and tubulin. The intact CCT complex is composed of eight polypeptides in a double ring structure. CCT is important within cells in the folding of the VHL tumor suppressor protein.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: CCT-theta; chaperonin subunit 8 (theta); T-complex protein 1 subunit theta; TCP-1-theta
基因别名: AI132397; Cct8; Cctq; Tcpq
UniProt ID: (Mouse) P42932
Entrez Gene ID: (Rat) 288305, (Mouse) 12469