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Invitrogen
TCR V beta 12 Monoclonal Antibody (S511), FITC
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TCR V beta 12 Antibody (TCR2654) in Flow
Flow cytometry analysis of TCR V beta 12 in normal human peripheral blood cells (bright red gates). Human blood was stained with an antibody panel containing TCR V beta 12-FITC (Product # TCR2654), CD3-PE (Product # 12-0036-42), and CD4-APC (Product # 17-0049-42). After lysing red blood cells and subsequent washes, the remaining cells were immediately run on an Attune NxT Flow Cytometer.
产品信息
TCR2654
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human,
Mouse
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
S511
抗原
Human TCR V beta 12
偶联物
激发/发射光谱
498/517 nm
查看光谱
形式
Liquid
浓度
0.15 mg/mL
纯化类型
Protein A
保存液
PBS with 0.5% BSA
内含物
0.1% sodium azide
保存条件
4°C, store in dark
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
TCR2654 targets TCR V beta 12 in FACS, IHC(F), IP, and TCA applications and shows reactivity with Human samples.
The TCR2654 immunogen is human TCR V beta 12.
靶标信息
The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease (ref5). T Cell and TCR Diversity Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
How to use the Panel Builder
Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.
