Product References
P140 Peptide Leads to Clearance of Autoreactive Lymphocytes and Normalizes Immune Response in Lupus-Prone Mice.
Frontiers in immunology
Schall N,Talamini L,Wilhelm M,Jouvin-Marche E,Muller S
11-5961-82 was used in Flow cytometry/Cell sorting to suggest that P140 belongs to a new family of non-immunosuppressive immunoregulators that do not correct T and B cell abnormalities but rather contribute to the clearance of deleterious T and B cells.
Tue Jun 21 00:00:00 EDT 2022
Aberrant cholesterol metabolic signaling impairs antitumor immunosurveillance through natural killer T cell dysfunction in obese liver.
Cellular & molecular immunology
Tang W,Zhou J,Yang W,Feng Y,Wu H,Mok MTS,Zhang L,Liang Z,Liu X,Xiong Z,Zeng X,Wang J,Lu J,Li J,Sun H,Tian X,Yeung PC,Hou Y,Lee HM,Lam CCH,Leung HHW,Chan AWH,To KF,Wong J,Lai PBS,Ng KKC,Wong SKH,Wong VWS,Kong APS,Sung JJY,Cheng ASL
11-5961-82 was used in Flow cytometry/Cell sorting to highlight mTORC1/SREBP2/cholesterol-mediated NKT dysfunction in the tumor-promoting NAFLD liver microenvironment, providing intervention strategies that invigorating NKT cells to control HCC in the obesity epidemic.
Fri Jul 01 00:00:00 EDT 2022
Niche-specific MHC II and PD-L1 regulate CD4+CD8αα+ intraepithelial lymphocyte differentiation.
The Journal of experimental medicine
Moon S,Park Y,Hyeon S,Kim YM,Kim JH,Kim H,Park S,Lee KJ,Koo BK,Ha SJ,Lee SW
Published figure using TCR beta monoclonal antibody (Product # 11-5961-82) in Flow Cytometry
Mon Apr 05 00:00:00 EDT 2021
Multifaceted modes of action of the anticancer probiotic Enterococcus hirae.
Cell death and differentiation
Goubet AG,Wheeler R,Fluckiger A,Qu B,Lemaître F,Iribarren K,Mondragón L,Tidjani Alou M,Pizzato E,Durand S,Derosa L,Aprahamian F,Bossut N,Moya-Nilges M,Derrien D,Chen G,Leduc M,Joseph A,Pons N,Le Chatelier E,Segata N,Yonekura S,Iebba V,Kepp O,Raoult D,André F,Kroemer G,Boneca IG,Zitvogel L,Daillère R
11-5961-82 was used in Flow cytometry/Cell sorting to surmise that immunological, metabolic, epithelial, and microbial modes of action of the live E. hirae cooperate to circumvent primary resistance to therapy.
Thu Jul 01 00:00:00 EDT 2021
Peptidylprolyl isomerase C (Ppic) regulates invariant Natural Killer T cell (iNKT) differentiation in mice.
European journal of immunology
Paiva RS,Ramos CV,Azenha SR,Alves C,Basto AP,Graca L,Martins VC
11-5961-82 was used in Flow Cytometry to show that Ppic is dispensable for myeloid cells, platelets, erythrocytes, αβ and γδ T lymphocytes in vivo in the steady state, while being involved in B and iNKT cell differentiation.
Sun Aug 01 00:00:00 EDT 2021
Cofilin1-driven actin dynamics controls migration of thymocytes and is essential for positive selection in the thymus.
Journal of cell science
Salz A,Gurniak C,Jönsson F,Witke W
11-5961 was used in Flow cytometry/Cell sorting to describe a novel role of cofilin1 in the physiological context of migration-dependent cell differentiation.
Fri Mar 06 00:00:00 EST 2020
Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells.
Nature communications
Lucas B,White AJ,Cosway EJ,Parnell SM,James KD,Jones ND,Ohigashi I,Takahama Y,Jenkinson WE,Anderson G
Published figure using TCR beta monoclonal antibody (Product # 11-5961-82) in Flow Cytometry
Mon May 04 00:00:00 EDT 2020
B7-CD28 co-stimulation modulates central tolerance via thymic clonal deletion and Treg generation through distinct mechanisms.
Nature communications
Watanabe M,Lu Y,Breen M,Hodes RJ
Published figure using TCR beta monoclonal antibody (Product # 11-5961-82) in Flow Cytometry
Tue Dec 08 00:00:00 EST 2020
Bisphosphoglycerate Mutase Deficiency Protects against Cerebral Malaria and Severe Malaria-Induced Anemia.
Cell reports
Xu G,van Bruggen R,Gualtieri CO,Moradin N,Fois A,Vallerand D,De Sa Tavares Russo M,Bassenden A,Lu W,Tam M,Lesage S,Girouard H,Avizonis DZ,Deblois G,Prchal JT,Stevenson M,Berghuis A,Muir T,Rabinowitz J,Vidal SM,Fodil N,Gros P
11-5961 was used in Flow cytometry/Cell sorting to highlight the importance of BPGM as a regulator of hemoglobin/oxyhemoglobin in malaria pathogenesis and suggest a new potential malaria therapeutic target.
Tue Sep 22 00:00:00 EDT 2020
Requirements for the differentiation of innate T-bethigh memory-phenotype CD4+ T lymphocytes under steady state.
Nature communications
Kawabe T,Yi J,Kawajiri A,Hilligan K,Fang D,Ishii N,Yamane H,Zhu J,Jankovic D,Kim KS,Trinchieri G,Sher A
Published figure using TCR beta monoclonal antibody (Product # 11-5961-82) in Flow Cytometry
Mon Jul 06 00:00:00 EDT 2020
ABCA1 Exerts Tumor-Suppressor Function in Myeloproliferative Neoplasms.
Cell reports
Viaud M,Abdel-Wahab O,Gall J,Ivanov S,Guinamard R,Sore S,Merlin J,Ayrault M,Guilbaud E,Jacquel A,Auberger P,Wang N,Levine RL,Tall AR,Yvan-Charvet L
11-5961 was used in Flow cytometry/Cell sorting to identify somatic mutations in ABCA1 that subvert its anti-proliferative and cholesterol efflux functions and permit the progression of myeloid neoplasms.
Tue Mar 10 00:00:00 EDT 2020
Recognition of human gastrointestinal cancer neoantigens by circulating PD-1+ lymphocytes.
The Journal of clinical investigation
Gros A,Tran E,Parkhurst MR,Ilyas S,Pasetto A,Groh EM,Robbins PF,Yossef R,Garcia-Garijo A,Fajardo CA,Prickett TD,Jia L,Gartner JJ,Ray S,Ngo L,Wunderllich JR,Yang JC,Rosenberg SA
11-5961-82 was used in Flow cytometry/Cell sorting to investigate whether peripheral blood could be used as an alternative minimally invasive source to identify lymphocytes targeting neoantigens in patients with GI cancer with relatively low mutation burden.
Fri Nov 01 00:00:00 EDT 2019
Immunologic Recognition of a Shared p53 Mutated Neoantigen in a Patient with Metastatic Colorectal Cancer.
Cancer immunology research
Lo W,Parkhurst M,Robbins PF,Tran E,Lu YC,Jia L,Gartner JJ,Pasetto A,Deniger D,Malekzadeh P,Shelton TE,Prickett T,Ray S,Kivitz S,Paria BC,Kriley I,Schrump DS,Rosenberg SA
11-5961 was used in Flow cytometry/Cell sorting to report the identification and characterization in one patient of T-cell receptors (TCRs) recognizing mutated p53 p.R175H, which is shared among a subset of patients with cancer.
Mon Apr 01 00:00:00 EDT 2019
CD160 serves as a negative regulator of NKT cells in acute hepatic injury.
Nature communications
Kim TJ,Park G,Kim J,Lim SA,Kim J,Im K,Shin MH,Fu YX,Del Rio ML,Rodriguez-Barbosa JI,Yee C,Suh KS,Kim SJ,Ha SJ,Lee KM
Published figure using TCR beta monoclonal antibody (Product # 11-5961-82) in Flow Cytometry
Mon Jul 22 00:00:00 EDT 2019
Qa-1-Restricted CD8+ T Cells Can Compensate for the Absence of Conventional T Cells during Viral Infection.
Cell reports
Anderson CK,Reilly EC,Lee AY,Brossay L
11-5961 was used in Flow cytometry/Cell sorting to study compensatory mechanisms in immune responses to viruses when classical T cell immunity has been evaded.
Tue Apr 09 00:00:00 EDT 2019
Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death.
Nature communications
Sasaki K,Himeno A,Nakagawa T,Sasaki Y,Kiyonari H,Iwai K
11-5961-82 was used in Flow Cytometry to show that T cell-mediated killing and sequential autoinflammation are common and crucial for pathogenic diversity during T cell-mediated autoimmune responses.
Wed Aug 28 00:00:00 EDT 2019
Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells.
Cell
Gaya M,Barral P,Burbage M,Aggarwal S,Montaner B,Warren Navia A,Aid M,Tsui C,Maldonado P,Nair U,Ghneim K,Fallon PG,Sekaly RP,Barouch DH,Shalek AK,Bruckbauer A,Strid J,Batista FD
Published figure using TCR beta monoclonal antibody (Product # 11-5961-82) in Flow Cytometry
Thu Jan 25 00:00:00 EST 2018
Transformation of Accessible Chromatin and 3D Nucleome Underlies Lineage Commitment of Early T Cells.
Immunity
Hu G,Cui K,Fang D,Hirose S,Wang X,Wangsa D,Jin W,Ried T,Liu P,Zhu J,Rothenberg EV,Zhao K
11-5961 was used in Flow cytometry/Cell sorting to find that abrupt genome-wide changes at all three levels of chromatin organization occur during the transition from double-negative stage 2 (DN2) to DN3, accompanying the T lineage commitment.
Tue Feb 20 00:00:00 EST 2018
A Macrophage Colony-Stimulating-Factor-Producing γδ T Cell Subset Prevents Malarial Parasitemic Recurrence.
Immunity
Mamedov MR,Scholzen A,Nair RV,Cumnock K,Kenkel JA,Oliveira JHM,Trujillo DL,Saligrama N,Zhang Y,Rubelt F,Schneider DS,Chien YH,Sauerwein RW,Davis MM
11-5961-82 was used in Flow Cytometry to point to an M-CSF-producing γδ T cell subset that fulfills a specialized protective role in the later stage of malaria infection when αβ T cells have declined.
Tue Feb 20 00:00:00 EST 2018
CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature.
Nature neuroscience
Louveau A,Herz J,Alme MN,Salvador AF,Dong MQ,Viar KE,Herod SG,Knopp J,Setliff JC,Lupi AL,Da Mesquita S,Frost EL,Gaultier A,Harris TH,Cao R,Hu S,Lukens JR,Smirnov I,Overall CC,Oliver G,Kipnis J
11-5961 was used in Flow cytometry/Cell sorting to demonstrate that meningeal lymphatics fulfill two critical criteria: they assist in the drainage of cerebrospinal fluid components and enable immune cells to enter draining lymph nodes in a CCR7-dependent manner.
Mon Oct 01 00:00:00 EDT 2018
STAT1 is a sex-specific tumor suppressor in colitis-associated colorectal cancer.
Molecular oncology
Crnčec I,Modak M,Gordziel C,Svinka J,Scharf I,Moritsch S,Pathria P,Schlederer M,Kenner L,Timelthaler G,Müller M,Strobl B,Casanova E,Bayer E,Mohr T,Stöckl J,Friedrich K,Eferl R
Published figure using TCR beta monoclonal antibody (Product # 11-5961-82) in Flow Cytometry
Sun Apr 01 00:00:00 EDT 2018
Invariant natural killer T-cell development and function with loss of microRNA-155.
Immunology
Frias AB,Buechel HM,Neupane A,D'Cruz LM
11-5961 was used in Flow cytometry/Cell sorting to examine the role of microRNA-155 in the development and function of invariant natural killer T cells.
Thu Feb 01 00:00:00 EST 2018
Gli3 in fetal thymic epithelial cells promotes thymocyte positive selection and differentiation by repression of Shh.
Development (Cambridge, England)
Solanki A,Yanez DC,Ross S,Lau CI,Papaioannou E,Li J,Saldaña JI,Crompton T
11-5961 was used in Flow cytometry/Cell sorting to show that Gli3 activity in mouse thymic epithelial cells promotes positive thymocyte selection and differentiation by Shh repression.
Wed Jan 31 00:00:00 EST 2018
Dysregulation of Kupffer Cells/Macrophages and Natural Killer T Cells in Steatohepatitis in LXRα Knockout Male Mice.
Endocrinology
Endo-Umeda K,Nakashima H,Umeda N,Seki S,Makishima M
11-5961 was used in Flow cytometry/Cell sorting to study the role fof LXRα in the pathogenesis of steatohepatitis.
Thu Mar 01 00:00:00 EST 2018
Differential requirement of kindlin-3 for T cell progenitor homing to the non-vascularized and vascularized thymus.
eLife
Moretti FA,Klapproth S,Ruppert R,Margraf A,Weber J,Pick R,Scheiermann C,Sperandio M,Fässler R,Moser M
Published figure using TCR beta monoclonal antibody (Product # 11-5961-82) in Flow Cytometry
Thu Sep 06 00:00:00 EDT 2018
Type 2 Innate Lymphocytes Actuate Immunity Against Tumours and Limit Cancer Metastasis.
Scientific reports
Saranchova I,Han J,Zaman R,Arora H,Huang H,Fenninger F,Choi KB,Munro L,Pfeifer CG,Welch I,Takei F,Jefferies WA
11-5961 was used in Flow cytometry/Cell sorting to study the role of type 2 innate lymphoid cells in enhancing anti-cancer immunity and controlling metastasis.
Tue Feb 13 00:00:00 EST 2018
Group 2 innate lymphoid cells protect lung endothelial cells from pyroptosis in sepsis.
Cell death & disease
Lai D,Tang J,Chen L,Fan EK,Scott MJ,Li Y,Billiar TR,Wilson MA,Fang X,Shu Q,Fan J
11-5961 was used in Flow cytometry/Cell sorting to describe the function of ILC2 in the regulation of lung inflammation by protecting lung endothelial cell from pyroptosis.
Tue Mar 06 00:00:00 EST 2018
A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia.
Cancer cell
Robles-Valero J,Lorenzo-Martín LF,Menacho-Márquez M,Fernández-Pisonero I,Abad A,Camós M,Toribio ML,Espinosa L,Bigas A,Bustelo XR
Published figure using TCR beta monoclonal antibody (Product # 11-5961-82) in Flow Cytometry
Mon Nov 13 00:00:00 EST 2017
1810011o10 Rik Inhibits the Antitumor Effect of Intratumoral CD8+ T Cells through Suppression of Notch2 Pathway in a Murine Hepatocellular Carcinoma Model.
Frontiers in immunology
Dai K,Huang L,Huang YB,Chen ZB,Yang LH,Jiang YA
Published figure using TCR beta monoclonal antibody (Product # 11-5961-82) in Flow Cytometry
Wed Nov 20 00:00:00 EST 2019
Regulatory T Cells Promote Myositis and Muscle Damage in Toxoplasma gondii Infection.
Journal of immunology (Baltimore, Md. : 1950)
Jin RM,Blair SJ,Warunek J,Heffner RR,Blader IJ,Wohlfert EA
11-5961 was used in Flow cytometry/Cell sorting to study how the tissue environment established by Toxoplasma gondii leads to a pathogenic role for regulatory T cells.
Sun Jan 01 00:00:00 EST 2017
MDSCs are involved in the protumorigenic potentials of GM-CSF in colitis-associated cancer.
International journal of immunopathology and pharmacology
Ma N,Liu Q,Hou L,Wang Y,Liu Z
Thu Jun 01 00:00:00 EDT 2017
Targeted genome editing restores T cell differentiation in a humanized X-SCID pluripotent stem cell disease model.
Scientific reports
Alzubi J,Pallant C,Mussolino C,Howe SJ,Thrasher AJ,Cathomen T
Published figure using TCR beta monoclonal antibody (Product # 11-5961-82) in Flow Cytometry
Fri Sep 29 00:00:00 EDT 2017
Resistance to TGFβ suppression and improved anti-tumor responses in CD8+ T cells lacking PTPN22.
Nature communications
Brownlie RJ,Garcia C,Ravasz M,Zehn D,Salmond RJ,Zamoyska R
11-5961 was used in Flow cytometry/Cell sorting to show that CD8+T cells that lack the tyrosine phosphatase Ptpn22, are resistant to the suppressing effects of transforming growth factor β.
Tue Nov 07 00:00:00 EST 2017
Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral Inflammation.
Cell
Wang A,Huen SC,Luan HH,Yu S,Zhang C,Gallezot JD,Booth CJ,Medzhitov R
11-5961 was used in an ELISA assay to analyse the effects of anorxia in mouse models wih viral and bacterial infections.
Thu Sep 08 00:00:00 EDT 2016
Hypoxia-Inducible Factor-2α Limits Natural Killer T Cell Cytotoxicity in Renal Ischemia/Reperfusion Injury.
Journal of the American Society of Nephrology : JASN
Zhang J,Han C,Dai H,Hou J,Dong Y,Cui X,Xu L,Zhang M,Xia Q
Published figure using TCR beta monoclonal antibody (Product # 11-5961-82) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2016
Environmental and Genetic Activation of Hypothalamic BDNF Modulates T-cell Immunity to Exert an Anticancer Phenotype.
Cancer immunology research
Xiao R,Bergin SM,Huang W,Slater AM,Liu X,Judd RT,Lin ED,Widstrom KJ,Scoville SD,Yu J,Caligiuri MA,Cao L
Published figure using TCR beta monoclonal antibody (Product # 11-5961-82) in Flow Cytometry
Wed Jun 01 00:00:00 EDT 2016
Id2 regulates hyporesponsive invariant natural killer T cells.
Immunology and cell biology
Stradner MH,Cheung KP,Lasorella A,Goldrath AW,D'Cruz LM
11-5961 was used in Flow cytometry/Cell sorting to propose that downregulation of Id2 expression is essential to induction of the anti-inflammatory state in iNKT cells.
Mon Aug 01 00:00:00 EDT 2016
Development of a diet-induced murine model of diabetes featuring cardinal metabolic and pathophysiological abnormalities of type 2 diabetes.
Biology open
Morris JL,Bridson TL,Alim MA,Rush CM,Rudd DM,Govan BL,Ketheesan N
11-5961 was used in Flow cytometry/Cell sorting to develop a novel murine model, based on an energy-dense diet, which closely simulates the development of type 2 diabetes.
Mon Aug 15 00:00:00 EDT 2016
Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1.
Nature communications
Ishikawa E,Kosako H,Yasuda T,Ohmuraya M,Araki K,Kurosaki T,Saito T,Yamasaki S
Published figure using TCR beta monoclonal antibody (Product # 11-5961-82) in Flow Cytometry
Tue Sep 27 00:00:00 EDT 2016
Cysteamine broadly improves the anti-plasmodial activity of artemisinins against murine blood stage and cerebral malaria.
Malaria journal
Moradin N,Torre S,Gauthier S,Tam M,Hawari J,Vandercruyssen K,De Spiegeleer B,Fortin A,Stevenson MM,Gros P
11-5961 was used in Flow cytometry/Cell sorting to evaluate the effect of artemisinins and cysteamine combination therapy on malarial phenotypes.
Fri May 06 00:00:00 EDT 2016
Ozone-induced IL-17A and neutrophilic airway inflammation is orchestrated by the caspase-1-IL-1 cascade.
Scientific reports
Che L,Jin Y,Zhang C,Lai T,Zhou H,Xia L,Tian B,Zhao Y,Liu J,Wu Y,Wu Y,Du J,Li W,Ying S,Chen Z,Shen H
11-5961 was used in Flow cytometry/Cell sorting to demonstrate that ozone-induced IL-17A and neutrophilic airway inflammation is orchestrated by the caspase-1-IL-1 cascade.
Thu Jan 07 00:00:00 EST 2016
LRBA is Essential for Allogeneic Responses in Bone Marrow Transplantation.
Scientific reports
Park MY,Sudan R,Srivastava N,Neelam S,Youngs C,Wang JW,Engelman RW,Kerr WG
11-5961 was used in Flow cytometry/Cell sorting to investigate the immune function of LRBA, showing that it is essential for allogenic responses in bone marrow transplantation.
Tue Nov 08 00:00:00 EST 2016
BAFF activation of the ERK5 MAP kinase pathway regulates B cell survival.
The Journal of experimental medicine
Jacque E,Schweighoffer E,Tybulewicz VL,Ley SC
11-5961 was used in Flow cytometry/Cell sorting to reveal a potentially critical role for the MEK5-ERK5 MAP kinase signalling pathway in BAFF-induced mature B cell survival and homeostatic maintenance of B2 cell numbers.
Mon Jun 01 00:00:00 EDT 2015
MHC-mismatched mixed chimerism augments thymic regulatory T-cell production and prevents relapse of EAE in mice.
Proceedings of the National Academy of Sciences of the United States of America
Wu L,Li N,Zhang M,Xue SL,Cassady K,Lin Q,Riggs AD,Zeng D
Published figure using TCR beta monoclonal antibody (Product # 11-5961-82) in Flow Cytometry
Tue Dec 29 00:00:00 EST 2015
NK-, NKT- and CD8-Derived IFNγ Drives Myeloid Cell Activation and Erythrophagocytosis, Resulting in Trypanosomosis-Associated Acute Anemia.
PLoS pathogens
Cnops J,De Trez C,Stijlemans B,Keirsse J,Kauffmann F,Barkhuizen M,Keeton R,Boon L,Brombacher F,Magez S
11-5961 was used in Flow cytometry/Cell sorting to show that NK, NKT and CD8+ T cell-derived IFNγ is a critical mediator in trypanosomosis-associated pathology.
Mon Jun 01 00:00:00 EDT 2015
Mouse dental pulp stem cells support human umbilical cord blood-derived hematopoietic stem/progenitor cells in vitro.
Cell transplantation
Nakatsuka R,Matsuoka Y,Uemura Y,Sumide K,Iwaki R,Takahashi M,Fujioka T,Sasaki Y,Sonoda Y
11-5961 was used in Flow cytometry/Cell sorting to demonstrate that prospectively isolated murine PDGFRα and Sca-1 double-positive dental pulp stem cells could support primitive human CD34+ and CD34- hematopoietic stem cells in vitro.
Wed Sep 16 00:00:00 EDT 2015
Antibiotics in neonatal life increase murine susceptibility to experimental psoriasis.
Nature communications
Zanvit P,Konkel JE,Jiao X,Kasagi S,Zhang D,Wu R,Chia C,Ajami NJ,Smith DP,Petrosino JF,Abbatiello B,Nakatsukasa H,Chen Q,Belkaid Y,Chen ZJ,Chen W
Published figure using TCR beta monoclonal antibody (Product # 11-5961-82) in Flow Cytometry
Tue Sep 29 00:00:00 EDT 2015
The cholesterol transporter ABCG1 links cholesterol homeostasis and tumour immunity.
Nature communications
Sag D,Cekic C,Wu R,Linden J,Hedrick CC
11-5961 was used in Flow cytometry/Cell sorting to demonstrate that the absence of ABCG1 inhibits tumour growth through modulation of macrophage function within the tumour.
Fri Feb 27 00:00:00 EST 2015
IKK2 inhibition using TPCA-1-loaded PLGA microparticles attenuates laser-induced choroidal neovascularization and macrophage recruitment.
PloS one
Gaddipati S,Lu Q,Kasetti RB,Miller MC,Lu Q,Trent JO,Kaplan HJ,Li Q
11-5961 was used in Flow cytometry/Cell sorting to suggest a potential clinical application of TPCA-1 delivered by microparticles in treatment of CNV in the patients with age-related macular degeneration and other retinal neovascularization diseases.
Thu Apr 07 00:00:00 EDT 2016
The tyrosine phosphatase PTPN22 discriminates weak self peptides from strong agonist TCR signals.
Nature immunology
Salmond RJ,Brownlie RJ,Morrison VL,Zamoyska R
11-5961 was used in Flow cytometry/Cell sorting to study how loss-of-function PTPN22 alleles can lead to the population expansion of effector and/or memory T cells and a predisposition to human autoimmunity.
Mon Sep 01 00:00:00 EDT 2014
CCDC88B is a novel regulator of maturation and effector functions of T cells during pathological inflammation.
The Journal of experimental medicine
Kennedy JM,Fodil N,Torre S,Bongfen SE,Olivier JF,Leung V,Langlais D,Meunier C,Berghout J,Langat P,Schwartzentruber J,Majewski J,Lathrop M,Vidal SM,Gros P
11-5961 was used in Flow cytometry/Cell sorting to suggest that CCDC88B is the morbid gene underlying the pleiotropic effect of the 11q13 locus on inflammation.
Mon Dec 15 00:00:00 EST 2014
Protective role for Toll-like receptor-9 in the development of atherosclerosis in apolipoprotein E-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology
Koulis C,Chen YC,Hausding C,Ahrens I,Kyaw TS,Tay C,Allen T,Jandeleit-Dahm K,Sweet MJ,Akira S,Bobik A,Peter K,Agrotis A
11-5961 was used in Flow cytometry/Cell sorting to investigate whether TLR9 has a role in the development of atherosclerosis in apolipoprotein E-deficient mice.
Sat Mar 01 00:00:00 EST 2014
Blocking junctional adhesion molecule C enhances dendritic cell migration and boosts the immune responses against Leishmania major.
PLoS pathogens
Ballet R,Emre Y,Jemelin S,Charmoy M,Tacchini-Cottier F,Imhof BA
11-5961 was used in Flow cytometry/Cell sorting to illustrate a key role for the vascular adhesion molecule JAM-C in controlling leukocyte migration and subsequent immune events in response to pathogen infections.
Mon Dec 01 00:00:00 EST 2014
Macrophage depletion abates Porphyromonas gingivalis-induced alveolar bone resorption in mice.
Journal of immunology (Baltimore, Md. : 1950)
Lam RS,O'Brien-Simpson NM,Lenzo JC,Holden JA,Brammar GC,Walsh KA,McNaughtan JE,Rowler DK,Van Rooijen N,Reynolds EC
11-5961 was used in Flow cytometry/Cell sorting to define the role of the macrophage in the immunopathology of periodontitis.
Mon Sep 01 00:00:00 EDT 2014
mTORC1-dependent metabolic reprogramming is a prerequisite for NK cell effector function.
Journal of immunology (Baltimore, Md. : 1950)
Donnelly RP,Loftus RM,Keating SE,Liou KT,Biron CA,Gardiner CM,Finlay DK
11-5961 was used in Flow cytometry/Cell sorting to investigate whether mTORC1-controlled metabolism underpins normal natural killer cell proinflammatory functions.
Sat Nov 01 00:00:00 EDT 2014
E and Id proteins influence invariant NKT cell sublineage differentiation and proliferation.
Journal of immunology (Baltimore, Md. : 1950)
D'Cruz LM,Stradner MH,Yang CY,Goldrath AW
11-5961 was used in Flow cytometry/Cell sorting to investigate the mechanism by which E and Id proteins control the development of invariant NKT sublineages after positive selection.
Sat Mar 01 00:00:00 EST 2014
Proximity of TCR and its CD8 coreceptor controls sensitivity of T cells.
Immunology letters
Borger JG,Zamoyska R,Gakamsky DM
11-5961 was used in Flow cytometry/Cell sorting to demonstrate a signalling mechanism for the functional avidity maturation of CD8(+) T cells.
Thu Jul 31 00:00:00 EDT 2014
Autophagy is a critical regulator of memory CD8(+) T cell formation.
eLife
Puleston DJ,Zhang H,Powell TJ,Lipina E,Sims S,Panse I,Watson AS,Cerundolo V,Townsend AR,Klenerman P,Simon AK
11-5961 was used in Flow cytometry/Cell sorting to show that mice lacking the autophagy gene Atg7 in T cells failed to establish CD8(+) T cell memory to influenza and MCMV infection.
Tue Nov 11 00:00:00 EST 2014
Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4⁺ T cell immunity.
Nature immunology
Reis BS,Rogoz A,Costa-Pinto FA,Taniuchi I,Mucida D
Published figure using TCR beta monoclonal antibody (Product # 11-5961-82) in Flow Cytometry
Fri Mar 01 00:00:00 EST 2013
Minor cell-death defects but reduced tumor latency in mice lacking the BH3-only proteins Bad and Bmf.
Oncogene
Baumgartner F,Woess C,Pedit V,Tzankov A,Labi V,Villunger A
11-5961 was used in Flow cytometry/Cell sorting to show that Bad and Bmf co-regulate lymphocyte homeostasis and limit spontaneous transformation in mice.
Thu Jan 31 00:00:00 EST 2013
Inactivation of tumor-specific CD8⁺ CTLs by tumor-infiltrating tolerogenic dendritic cells.
Immunology and cell biology
Harimoto H,Shimizu M,Nakagawa Y,Nakatsuka K,Wakabayashi A,Sakamoto C,Takahashi H
11-5961 was used in Flow cytometry/Cell sorting to investigate cancer immunosurveillance failure caused by the inactivation of CD8+ cytotoxic T lymphocytes by tolerogenic dendritic cells.
Tue Oct 01 00:00:00 EDT 2013
γδ T cells recognize a microbial encoded B cell antigen to initiate a rapid antigen-specific interleukin-17 response.
Immunity
Zeng X,Wei YL,Huang J,Newell EW,Yu H,Kidd BA,Kuhns MS,Waters RW,Davis MM,Weaver CT,Chien YH
11-5961 was used in Flow cytometry/Cell sorting to study the γδ T cell response to the algae protein, phycoerythrin.
Fri Sep 21 00:00:00 EDT 2012
Preventing and curing citrulline-induced autoimmune arthritis in a humanized mouse model using a Th2-polarizing iNKT cell agonist.
Immunology and cell biology
Walker KM,Rytelewski M,Mazzuca DM,Meilleur SA,Mannik LA,Yue D,Brintnell WC,Welch I,Cairns E,Haeryfar SM
11-5961 was used in Flow cytometry/Cell sorting to demonstrate that treatment with a Th2-skewing iNKT cell agonist prevents citrulline-induced autoimmune arthritis.
Sun Jul 01 00:00:00 EDT 2012
Neonatal rhinovirus infection induces mucous metaplasia and airways hyperresponsiveness.
Journal of immunology (Baltimore, Md. : 1950)
Schneider D,Hong JY,Popova AP,Bowman ER,Linn MJ,McLean AM,Zhao Y,Sonstein J,Bentley JK,Weinberg JB,Lukacs NW,Curtis JL,Sajjan US,Hershenson MB
11-5961 was used in Flow cytometry/Cell sorting to conclude that neonatal RV1B infection leads to persistent airway inflammation, in part mediated by IL-13.
Thu Mar 15 00:00:00 EDT 2012
Differential requirements for IRF-2 in generation of CD1d-independent T cells bearing NK cell receptors.
Journal of immunology (Baltimore, Md. : 1950)
Notake T,Horisawa S,Sanjo H,Miyagawa S,Hida S,Taki S
11-5961 was used in Flow cytometry/Cell sorting to investigate the mechanisms behind the generation and function of NKR(+) T cells.
Tue May 15 00:00:00 EDT 2012
Small intestinal intraepithelial lymphocytes expressing CD8 and T cell receptor γδ are involved in bacterial clearance during Salmonella enterica serovar Typhimurium infection.
Infection and immunity
Li Z,Zhang C,Zhou Z,Zhang J,Zhang J,Tian Z
11-5961 was used in Flow cytometry/Cell sorting to investigate the role of intestinal intraepithelial lymphocytes in responding to oral infection, showing that they express CD8 and T cell receptor γδ for bacterial clearance.
Wed Feb 01 00:00:00 EST 2012
Overexpression of Uromodulin-like1 accelerates follicle depletion and subsequent ovarian degeneration.
Cell death & disease
Wang W,Tang Y,Ni L,Kim E,Jongwutiwes T,Hourvitz A,Zhang R,Xiong H,Liu HC,Rosenwaks Z
Published figure using TCR beta monoclonal antibody (Product # 11-5961-82) in Immunofluorescence
Thu Nov 29 00:00:00 EST 2012
Overexpression of Uromodulin-like1 accelerates follicle depletion and subsequent ovarian degeneration.
Cell death & disease
Wang W,Tang Y,Ni L,Kim E,Jongwutiwes T,Hourvitz A,Zhang R,Xiong H,Liu HC,Rosenwaks Z
Published figure using TCR beta monoclonal antibody (Product # 11-5961-82) in Immunofluorescence
Thu Nov 29 00:00:00 EST 2012
Depletion of B2 but not B1a B cells in BAFF receptor-deficient ApoE mice attenuates atherosclerosis by potently ameliorating arterial inflammation.
PloS one
Kyaw T,Tay C,Hosseini H,Kanellakis P,Gadowski T,MacKay F,Tipping P,Bobik A,Toh BH
11-5961 was used in Flow cytometry/Cell sorting to demonstrate that B2 cells are important contributors to the development of atherosclerosis, and to determine the mechanism of contribution.
Mon May 14 00:00:00 EDT 2012
Low 2-dimensional CD4 T cell receptor affinity for myelin sets in motion delayed response kinetics.
PloS one
Rosenthal KM,Edwards LJ,Sabatino JJ,Hood JD,Wasserman HA,Zhu C,Evavold BD
11-5961 was used in a micropipette adhesion frequency assay to demonstrate that time can offset low T cell receptor affinity to attain full activation and suggest a mechanism by which low affinity T cells participate in autoimmune disease.
Thu Aug 02 00:00:00 EDT 2012
The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance.
The Journal of experimental medicine
Mortensen M,Soilleux EJ,Djordjevic G,Tripp R,Lutteropp M,Sadighi-Akha E,Stranks AJ,Glanville J,Knight S,Jacobsen SE,Kranc KR,Simon AK
11-5961 was used in Flow cytometry/Cell sorting to show that Atg7 is an essential regulator of adult hematopoietic stem cell maintenance.
Mon Mar 14 00:00:00 EDT 2011
Distinct MHC class I-dependent NK cell-activating receptors control cytomegalovirus infection in different mouse strains.
The Journal of experimental medicine
Pyzik M,Charbonneau B,Gendron-Pontbriand EM,Babić M,Krmpotić A,Jonjić S,Vidal SM
11-5961 was used in Flow cytometry/Cell sorting to study how multiple activating Ly49 receptors may participate in H-2-dependent recognition of MCMV infection, providing a common mechanism of NK cell-mediated resistance against viral infection.
Mon May 09 00:00:00 EDT 2011
H2 control of natural T regulatory cell frequency in the lymph node correlates with susceptibility to day 3 thymectomy-induced autoimmune disease.
Journal of immunology (Baltimore, Md. : 1950)
del Rio R,Sun Y,Alard P,Tung KS,Teuscher C
11-5961 was used in Flow cytometry/Cell sorting to confirm that quantitative trait loci on a range of chromosomes control susceptibility to autoimmune ovarian dysgenesis.
Sat Jan 01 00:00:00 EST 2011
T regulatory cells maintain intestinal homeostasis by suppressing γδ T cells.
Immunity
Park SG,Mathur R,Long M,Hosh N,Hao L,Hayden MS,Ghosh S
11-5961 was used in Flow cytometry/Cell sorting to explore the regulatory processes maintaining a tolerogenic attitude towards enteric commensal bacteria.
Wed Nov 24 00:00:00 EST 2010
Replication allows inactivation of a knocked-in locus control region in inappropriate cell lineages.
Proceedings of the National Academy of Sciences of the United States of America
Menzel U,Ktistaki E,Tolaini M,Veiga-Fernandes H,Kioussis D
11-5961 was used in Flow cytometry/Cell sorting to explore the effect of a locus control region on a developmentally regulated locus in the mouse CD8 gene complex.
Tue Sep 28 00:00:00 EDT 2010
Differential geminin requirement for proliferation of thymocytes and mature T cells.
Journal of immunology (Baltimore, Md. : 1950)
Karamitros D,Kotantaki P,Lygerou Z,Veiga-Fernandes H,Pachnis V,Kioussis D,Taraviras S
11-5961 was used in Flow cytometry/Cell sorting to gain insight into the in vivo role of Geminin in progenitor cell division and differentiation.
Mon Mar 01 00:00:00 EST 2010
Additive and global functions of HoxA cluster genes in mesoderm derivatives.
Developmental biology
Di-Poï N,Koch U,Radtke F,Duboule D
11-5961 was used in Flow cytometry/Cell sorting to report that mutant mice lacking the entire HoxA cluster in mesodermal lineages display the expected spectrum of postnatal respiratory, cardiac and urogenital defects, previously reported for single gene mutations.
Sat May 15 00:00:00 EDT 2010
Invariant natural killer T cells suppress the neutrophil inflammatory response in a mouse model of cholestatic liver damage.
Gastroenterology
Wintermeyer P,Cheng CW,Gehring S,Hoffman BL,Holub M,Brossay L,Gregory SH
11-5961 was used in Flow cytometry/Cell sorting to show the role of iNKT cells in suppressing the neutrophil proinflammatory response and neutrophil-dependent cholestatic liver damage.
Sun Mar 01 00:00:00 EST 2009
Enhanced development of CD4+ gammadelta T cells in the absence of Itk results in elevated IgE production.
Blood
Qi Q,Xia M,Hu J,Hicks E,Iyer A,Xiong N,August A
11-5961 was used in Flow cytometry/Cell sorting to investigate the effect of Itk on T cell populations, showing that development of CD4+ gammadelta T cells is enhanced and IgE production is elevated in the absence of Itk.
Thu Jul 16 00:00:00 EDT 2009
Lymphotoxin beta receptor signaling promotes tertiary lymphoid organogenesis in the aorta adventitia of aged ApoE-/- mice.
The Journal of experimental medicine
Gräbner R,Lötzer K,Döpping S,Hildner M,Radke D,Beer M,Spanbroek R,Lippert B,Reardon CA,Getz GS,Fu YX,Hehlgans T,Mebius RE,van der Wall M,Kruspe D,Englert C,Lovas A,Hu D,Randolph GJ,Weih F,Habenicht AJ
11-5961 was used in Flow cytometry/Cell sorting to investigate how the LTbetaR pathway has a major role in shaping the immunological characteristics and overall integrity of the arterial wall.
Fri Jan 16 00:00:00 EST 2009
A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity.
The Journal of experimental medicine
Hsu LY,Tan YX,Xiao Z,Malissen M,Weiss A
11-5961 was used in Flow cytometry/Cell sorting to discover signalling differences from ZAP-70 mutations skew the T cell receptor repertoire, differentially influencing propensity to autoimmunity versus autoimmune disease susceptibility.
Mon Oct 26 00:00:00 EDT 2009
Natural killer cells modulate overt autoimmunity to homeostasis in nonobese diabetic mice after anti-CD3 F(ab')2 antibody treatment through secreting transforming growth factor-beta.
The American journal of pathology
Chen G,Han G,Wang J,Wang R,Xu R,Shen B,Qian J,Li Y
11-5961 was used in Flow cytometry/Cell sorting to investigate the mechanisms underlying the use of anti-CD3 for treatment of overt autoimmunity, showing that natural killer cells modulate autoimmunity through secreting TGF-beta.
Tue Sep 01 00:00:00 EDT 2009
Polysialic acid, a glycan with highly restricted expression, is found on human and murine leukocytes and modulates immune responses.
Journal of immunology (Baltimore, Md. : 1950)
Drake PM,Nathan JK,Stock CM,Chang PV,Muench MO,Nakata D,Reader JR,Gip P,Golden KP,Weinhold B,Gerardy-Schahn R,Troy FA,Bertozzi CR
11-5961 was used in Flow cytometry/Cell sorting to investigate the expression and possible function of polysialic acid in the immune system.
Sat Nov 15 00:00:00 EST 2008
Polysialic acid, a glycan with highly restricted expression, is found on human and murine leukocytes and modulates immune responses.
Journal of immunology (Baltimore, Md. : 1950)
Drake PM,Nathan JK,Stock CM,Chang PV,Muench MO,Nakata D,Reader JR,Gip P,Golden KP,Weinhold B,Gerardy-Schahn R,Troy FA,Bertozzi CR
11-5961 was used in Flow cytometry/Cell sorting to investigate the expression and possible function of polysialic acid in the immune system.
Sat Nov 15 00:00:00 EST 2008
Respiratory Francisella tularensis live vaccine strain infection induces Th17 cells and prostaglandin E2, which inhibits generation of gamma interferon-positive T cells.
Infection and immunity
Woolard MD,Hensley LL,Kawula TH,Frelinger JA
11-5961 was used in Flow cytometry/Cell sorting to illuminate a critical differences in acute adaptive immune responses between inhalational and dermal infection with F. tularensis LVS.
Sun Jun 01 00:00:00 EDT 2008
The Pten/PI3K pathway governs the homeostasis of Valpha14iNKT cells.
Blood
Kishimoto H,Ohteki T,Yajima N,Kawahara K,Natsui M,Kawarasaki S,Hamada K,Horie Y,Kubo Y,Arase S,Taniguchi M,Vanhaesebroeck B,Mak TW,Nakano T,Koyasu S,Sasaki T,Suzuki A
11-5961 was used in Flow cytometry/Cell sorting to describe the phenotype of Pten-deficient Valpha14iNKT cells.
Sun Apr 15 00:00:00 EDT 2007
Dual functions of Runx proteins for reactivating CD8 and silencing CD4 at the commitment process into CD8 thymocytes.
Immunity
Sato T,Ohno S,Hayashi T,Sato C,Kohu K,Satake M,Habu S
11-5961 was used in Flow cytometry/Cell sorting to investigate the involvement of Runx proteins in the lineage specification of CD8 T cells.
Tue Mar 01 00:00:00 EST 2005