Product References
Reprogramming of Tumor-reactive Tumor-infiltrating Lymphocytes to Human-induced Pluripotent Stem Cells.
Cancer research communications
Islam SMR,Maeda T,Tamaoki N,Good ML,Kishton RJ,Paria BC,Yu Z,Bosch-Marce M,Bedanova NM,Liu C,Kruhlak MJ,Restifo NP,Vizcardo R
47-5961-82 was used in Flow Cytometry to reprogram exhausted TIL that possess T-cell receptors (TCR) specific for tumor antigens into induced pluripotent stem cells (iPSC) to rejuvenate them for more potent ACT.
Mon May 01 00:00:00 EDT 2023
RIPK3 controls MAIT cell accumulation during development but not during infection.
Cell death & disease
Patton T,Zhao Z,Lim XY,Eddy E,Wang H,Nelson AG,Ennis B,Eckle SBG,Souter MNT,Pediongco TJ,Koay HF,Zhang JG,Djajawi TM,Louis C,Lalaoui N,Jacquelot N,Lew AM,Pellicci DG,McCluskey J,Zhan Y,Chen Z,Lawlor KE,Corbett AJ
47-5961-82 was used in Flow cytometry/Cell sorting to suggest that, distinct from conventional T cells, the accumulation of MAIT cells is restrained by RIPK3 signalling, likely prior to thymic egress, in a manner independent of canonical apoptotic and necroptotic cell death pathways.
Sat Feb 11 00:00:00 EST 2023
The activity of the aryl hydrocarbon receptor in T cells tunes the gut microenvironment to sustain autoimmunity and neuroinflammation.
PLoS biology
Merchak AR,Cahill HJ,Brown LC,Brown RM,Rivet-Noor C,Beiter RM,Slogar ER,Olgun DG,Gaultier A
47-5961-82 was used in Flow cytometry/Cell sorting to demonstrate a newly emerging role for AHR in mediating the interdependence between T lymphocytes and the microbiota, while simultaneously identifying new potential molecular targets for the treatment of MS and other autoimmune diseases.
Wed Feb 01 00:00:00 EST 2023
Divergent metabolic programmes control two populations of MAIT cells that protect the lung.
Nature cell biology
Riffelmacher T,Paynich Murray M,Wientjens C,Chandra S,Cedillo-Castelán V,Chou TF,McArdle S,Dillingham C,Devereaux J,Nilsen A,Brunel S,Lewinsohn DM,Hasty J,Seumois G,Benedict CA,Vijayanand P,Kronenberg M
47-5961-82 was used in Flow cytometry/Cell sorting to investigate the metabolic dependencies that enable tuning of memory-like MAIT cell responses following pulmonary immunization with a Salmonella vaccine strain, revealing distinct CD127+ and Klrg1+ MAIT cell populations with divergent metabolic profiles and functions.
Thu Jun 01 00:00:00 EDT 2023
SHLD1 is dispensable for 53BP1-dependent V(D)J recombination but critical for productive class switch recombination.
Nature communications
Vincendeau E,Wei W,Zhang X,Planchais C,Yu W,Lenden-Hasse H,Cokelaer T,Pipoli da Fonseca J,Mouquet H,Adams DJ,Alt FW,Jackson SP,Balmus G,Lescale C,Deriano L
47-5961-82 was used in Immunocytochemistry-immunoflourescence to suggest that 53BP1 promotes V(D)J recombination and CSR through two distinct mechanisms: SHLD-independent synapsis of V(D)J segments and switch regions within chromatin, and SHLD-dependent protection of AID-DSB ends against resection.
Tue Jun 28 00:00:00 EDT 2022
Symbiotic bacteria-dependent expansion of MR1-reactive T cells causes autoimmunity in the absence of Bcl11b.
Nature communications
Shibata K,Motozono C,Nagae M,Shimizu T,Ishikawa E,Motooka D,Okuzaki D,Izumi Y,Takahashi M,Fujimori N,Wing JB,Hayano T,Asai Y,Bamba T,Ogawa Y,Furutani-Seiki M,Shirai M,Yamasaki S
47-5961-82 was used in Flow cytometry/Cell sorting to report that mice in which a T cell-specific transcription factor, B-cell lymphoma/leukemia 11B (Bcl11b), was ablated in immature thymocytes (Bcl11b?iThy mice) develop chronic inflammation.
Mon Nov 14 00:00:00 EST 2022
Stress-induced despair behavior develops independently of the Ahr-RORγt axis in CD4 + cells.
Scientific reports
Rivet-Noor CR,Merchak AR,Li S,Beiter RM,Lee S,Thomas JA,Fernández-Castañeda A,Shin JB,Gaultier A
47-5961-82 was used in Flow cytometry/Cell sorting to demonstrate that neither CD4 specific Ahr nor Rorc are necessary for the development of stress-induced anxiety- or depressive-like behaviors.
Sat May 21 00:00:00 EDT 2022
Environmental enteric dysfunction induces regulatory T cells that inhibit local CD4+ T cell responses and impair oral vaccine efficacy.
Immunity
Bhattacharjee A,Burr AHP,Overacre-Delgoffe AE,Tometich JT,Yang D,Huckestein BR,Linehan JL,Spencer SP,Hall JA,Harrison OJ,Morais da Fonseca D,Norton EB,Belkaid Y,Hand TW
47-5961-82 was used in Flow Cytometry to provide insight into the poor efficacy of oral vaccines in EED and highlight how RORγT+FOXP3+ Treg cells can regulate intestinal immunity while leaving systemic responses intact.
Tue Aug 10 00:00:00 EDT 2021
Niche-specific MHC II and PD-L1 regulate CD4+CD8αα+ intraepithelial lymphocyte differentiation.
The Journal of experimental medicine
Moon S,Park Y,Hyeon S,Kim YM,Kim JH,Kim H,Park S,Lee KJ,Koo BK,Ha SJ,Lee SW
Published figure using TCR beta monoclonal antibody (Product # 47-5961-82) in Flow Cytometry
Mon Apr 05 00:00:00 EDT 2021
Redundant cytokine requirement for intestinal microbiota-induced Th17 cell differentiation in draining lymph nodes.
Cell reports
Sano T,Kageyama T,Fang V,Kedmi R,Martinez CS,Talbot J,Chen A,Cabrera I,Gorshko O,Kurakake R,Yang Y,Ng C,Schwab SR,Littman DR
47-5961-82 was used in Flow Cytometry to show that intestine-draining mesenteric lymph nodes (MLNs), not intestine proper, are the dominant site of SFB-induced intestinal Th17 cell differentiation.
Tue Aug 24 00:00:00 EDT 2021
Protein Prenylation Drives Discrete Signaling Programs for the Differentiation and Maintenance of Effector Treg Cells.
Cell metabolism
Su W,Chapman NM,Wei J,Zeng H,Dhungana Y,Shi H,Saravia J,Zhou P,Long L,Rankin S,Kc A,Vogel P,Chi H
47-5961-82 was used in Flow Cytometry to identify bidirectional metabolic signaling, specifically between immunoreceptor signaling and metabolism-mediated posttranslational lipid modifications, for the differentiation and maintenance of eTreg cells.
Tue Dec 01 00:00:00 EST 2020
Combined Prebiotic and Microbial Intervention Improves Oral Cholera Vaccination Responses in a Mouse Model of Childhood Undernutrition.
Cell host & microbe
Di Luccia B,Ahern PP,Griffin NW,Cheng J,Guruge JL,Byrne AE,Rodionov DA,Leyn SA,Osterman AL,Ahmed T,Colonna M,Barratt MJ,Delahaye NF,Gordon JI
47-5961-82 was used in Flow Cytometry to provide preclinical proof-of-concept that diet and microbiota influence mucosal immune responses to CT vaccination and identify a candidate synbiotic formulation.
Wed Jun 10 00:00:00 EDT 2020
Notch dimerization and gene dosage are important for normal heart development, intestinal stem cell maintenance, and splenic marginal zone B-cell homeostasis during mite infestation.
PLoS biology
Kobia FM,Preusse K,Dai Q,Weaver N,Hass MR,Chaturvedi P,Stein SJ,Pear WS,Yuan Z,Kovall RA,Kuang Y,Eafergen N,Sprinzak D,Gebelein B,Brunskill EW,Kopan R
47-5961 was used in Flow cytometry/Cell sorting to highlight the role of the environment in malignancy and colitis and is consistent with Notch-dependent anti-parasite immune responses being compromised in Notch dimer-deficient animals.
Thu Oct 01 00:00:00 EDT 2020
Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells.
Nature communications
Lucas B,White AJ,Cosway EJ,Parnell SM,James KD,Jones ND,Ohigashi I,Takahama Y,Jenkinson WE,Anderson G
Published figure using TCR beta monoclonal antibody (Product # 47-5961-82) in Flow Cytometry
Mon May 04 00:00:00 EDT 2020
Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells.
Nature communications
Lucas B,White AJ,Cosway EJ,Parnell SM,James KD,Jones ND,Ohigashi I,Takahama Y,Jenkinson WE,Anderson G
Published figure using TCR beta monoclonal antibody (Product # 47-5961-82) in Flow Cytometry
Mon May 04 00:00:00 EDT 2020
B7-CD28 co-stimulation modulates central tolerance via thymic clonal deletion and Treg generation through distinct mechanisms.
Nature communications
Watanabe M,Lu Y,Breen M,Hodes RJ
Published figure using TCR beta monoclonal antibody (Product # 47-5961-82) in Flow Cytometry
Tue Dec 08 00:00:00 EST 2020
Requirements for the differentiation of innate T-bethigh memory-phenotype CD4+ T lymphocytes under steady state.
Nature communications
Kawabe T,Yi J,Kawajiri A,Hilligan K,Fang D,Ishii N,Yamane H,Zhu J,Jankovic D,Kim KS,Trinchieri G,Sher A
Published figure using TCR beta monoclonal antibody (Product # 47-5961-82) in Flow Cytometry
Mon Jul 06 00:00:00 EDT 2020
The cis-Regulatory Atlas of the Mouse Immune System.
Cell
Yoshida H,Lareau CA,Ramirez RN,Rose SA,Maier B,Wroblewska A,Desland F,Chudnovskiy A,Mortha A,Dominguez C,Tellier J,Kim E,Dwyer D,Shinton S,Nabekura T,Qi Y,Yu B,Robinette M,Kim KW,Wagers A,Rhoads A,Nutt SL,Brown BD,Mostafavi S,Buenrostro JD,Benoist C
47-5961-82 was used in Flow Cytometry to generate matched epigenome and transcriptome measurements in 86 primary cell types that span the mouse immune system and its differentiation cascade.
Thu Feb 07 00:00:00 EST 2019
Natural Genetic Variation Reveals Key Features of Epigenetic and Transcriptional Memory in Virus-Specific CD8 T Cells.
Immunity
van der Veeken J,Zhong Y,Sharma R,Mazutis L,Dao P,Pe'er D,Leslie CS,Rudensky AY
47-5961 was used in Immuno-assay to provide insights into the molecular mechanisms driving virus-specific CD8 T cell responses and suggest a general mechanism for the formation of transcriptional and epigenetic memory applicable to other immune and non-immune cells.
Tue May 21 00:00:00 EDT 2019
Lineage-specific events underlie aortic root aneurysm pathogenesis in Loeys-Dietz syndrome.
The Journal of clinical investigation
MacFarlane EG,Parker SJ,Shin JY,Kang BE,Ziegler SG,Creamer TJ,Bagirzadeh R,Bedja D,Chen Y,Calderon JF,Weissler K,Frischmeyer-Guerrerio PA,Lindsay ME,Habashi JP,Dietz HC
47-5961 was used in Flow cytometry/Cell sorting to highlight the importance of considering the regional microenvironment and specifically lineage-dependent variation in the vulnerability to mutations in the developmnet and testing of pathogenic models for aortic aneurysm.
Fri Feb 01 00:00:00 EST 2019
CD160 serves as a negative regulator of NKT cells in acute hepatic injury.
Nature communications
Kim TJ,Park G,Kim J,Lim SA,Kim J,Im K,Shin MH,Fu YX,Del Rio ML,Rodriguez-Barbosa JI,Yee C,Suh KS,Kim SJ,Ha SJ,Lee KM
Published figure using TCR beta monoclonal antibody (Product # 47-5961-82) in Flow Cytometry
Mon Jul 22 00:00:00 EDT 2019
CX3CL1-Fc treatment prevents atherosclerosis in Ldlr KO mice.
Molecular metabolism
Riopel M,Vassallo M,Ehinger E,Pattison J,Bowden K,Winkels H,Wilson M,de Jong R,Patel S,Balakrishna D,Bilakovics J,Fanjul A,Plonowski A,Larson CJ,Ley K,Cabrales P,Witztum JL,Olefsky JM,Lee YS
47-5961 was used in Flow cytometry/Cell sorting to indicate that CX3CL1-Fc can inhibit monocyte/endothelial cell adhesion as well as reduce atherosclerosis.
Fri Feb 01 00:00:00 EST 2019
Progranulin prevents regulatory NK cell cytotoxicity against antiviral T cells.
JCI insight
Huang A,Shinde PV,Huang J,Senff T,Xu HC,Margotta C,Häussinger D,Willnow TE,Zhang J,Pandyra AA,Timm J,Weggen S,Lang KS,Lang PA
47-5961 was used in Flow cytometry/Cell sorting to show that progranulin (PGRN) can reduce NK cell cytotoxicity through reduction of NK cell expansion, granzyme B transcription, and NK cell-mediated lysis of target cells.
Thu Sep 05 00:00:00 EDT 2019
B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage.
Nature communications
Wong JB,Hewitt SL,Heltemes-Harris LM,Mandal M,Johnson K,Rajewsky K,Koralov SB,Clark MR,Farrar MA,Skok JA
47-5961-82 was used in Flow Cytometry to show that in the fetal liver versus bone marrow environment, reduced IL-7R/STAT5 levels promote immunoglobulin kappa gene recombination at the early pro-B cell stage.
Fri Oct 18 00:00:00 EDT 2019
Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells.
Cell
Gaya M,Barral P,Burbage M,Aggarwal S,Montaner B,Warren Navia A,Aid M,Tsui C,Maldonado P,Nair U,Ghneim K,Fallon PG,Sekaly RP,Barouch DH,Shalek AK,Bruckbauer A,Strid J,Batista FD
Published figure using TCR beta monoclonal antibody (Product # 47-5961-82) in Flow Cytometry
Thu Jan 25 00:00:00 EST 2018
A Macrophage Colony-Stimulating-Factor-Producing γδ T Cell Subset Prevents Malarial Parasitemic Recurrence.
Immunity
Mamedov MR,Scholzen A,Nair RV,Cumnock K,Kenkel JA,Oliveira JHM,Trujillo DL,Saligrama N,Zhang Y,Rubelt F,Schneider DS,Chien YH,Sauerwein RW,Davis MM
47-5961-82 was used in Flow Cytometry to point to an M-CSF-producing γδ T cell subset that fulfills a specialized protective role in the later stage of malaria infection when αβ T cells have declined.
Tue Feb 20 00:00:00 EST 2018
De Novo Fatty Acid Synthesis During Mycobacterial Infection Is a Prerequisite for the Function of Highly Proliferative T Cells, But Not for Dendritic Cells or Macrophages.
Frontiers in immunology
Stüve P,Minarrieta L,Erdmann H,Arnold-Schrauf C,Swallow M,Guderian M,Krull F,Hölscher A,Ghorbani P,Behrends J,Abraham WR,Hölscher C,Sparwasser TD,Berod L
47-5961-82 was used in Flow Cytometry to reveal that acetyl-CoA carboxylase 1-dependent fatty acid synthesis is a crucial mechanism in T cells, but not dendritic cells or macrophages, to fight against mycobacterial infection.
Wed Apr 10 00:00:00 EDT 2019
STAT1 is a sex-specific tumor suppressor in colitis-associated colorectal cancer.
Molecular oncology
Crnčec I,Modak M,Gordziel C,Svinka J,Scharf I,Moritsch S,Pathria P,Schlederer M,Kenner L,Timelthaler G,Müller M,Strobl B,Casanova E,Bayer E,Mohr T,Stöckl J,Friedrich K,Eferl R
Published figure using TCR beta monoclonal antibody (Product # 47-5961-82) in Flow Cytometry
Sun Apr 01 00:00:00 EDT 2018
Differential requirement of kindlin-3 for T cell progenitor homing to the non-vascularized and vascularized thymus.
eLife
Moretti FA,Klapproth S,Ruppert R,Margraf A,Weber J,Pick R,Scheiermann C,Sperandio M,Fässler R,Moser M
Published figure using TCR beta monoclonal antibody (Product # 47-5961-82) in Flow Cytometry
Thu Sep 06 00:00:00 EDT 2018
A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment.
eLife
Ng KK,Yui MA,Mehta A,Siu S,Irwin B,Pease S,Hirose S,Elowitz MB,Rothenberg EV,Kueh HY
47-5961 was used in Flow cytometry/Cell sorting to study the activation of Bcl11b, which controls T-cell fate commitment.
Tue Nov 20 00:00:00 EST 2018
Peroxisomal β-oxidation regulates whole body metabolism, inflammatory vigor, and pathogenesis of nonalcoholic fatty liver disease.
JCI insight
Moreno-Fernandez ME,Giles DA,Stankiewicz TE,Sheridan R,Karns R,Cappelletti M,Lampe K,Mukherjee R,Sina C,Sallese A,Bridges JP,Hogan SP,Aronow BJ,Hoebe K,Divanovic S
47-5961 was used in Flow cytometry/Cell sorting to demonstrate that β-oxidation links metabolism and immune responsiveness.
Thu Mar 22 00:00:00 EDT 2018
Mrp1 is involved in lipid presentation and iNKT cell activation by Streptococcus pneumoniae.
Nature communications
Chandra S,Gray J,Kiosses WB,Khurana A,Hitomi K,Crosby CM,Chawla A,Fu Z,Zhao M,Veerapen N,Richardson SK,Porcelli SA,Besra G,Howell AR,Sharma S,Peters B,Kronenberg M
47-5961 was used in Flow cytometry/Cell sorting to elucidate the CD1d presentation pathway.
Mon Oct 15 00:00:00 EDT 2018
Runx-dependent and silencer-independent repression of a maturation enhancer in the Cd4 gene.
Nature communications
Kojo S,Yasmin N,Muroi S,Tenno M,Taniuchi I
47-5961 was used in Flow cytometry/Cell sorting to identify a late-acting maturation enhancer which plays essential roles for activation of both the early-acting proximal enhancer and maturation enhancer of Cd4.
Wed Sep 05 00:00:00 EDT 2018
Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha.
Nature communications
Govindarajan S,Gaublomme D,Van der Cruyssen R,Verheugen E,Van Gassen S,Saeys Y,Tavernier S,Iwawaki T,Bloch Y,Savvides SN,Lambrecht BN,Janssens S,Elewaut D,Drennan MB
47-5961 was used in Flow cytometry/Cell sorting to examine the role of the IRE1α-dependent signalling cascade in coupling constitutive cytokine mRNA expression to the rapid induction of cytokine secretion and effector functions in activated iNKT cells.
Mon Dec 17 00:00:00 EST 2018
Stability and function of regulatory T cells expressing the transcription factor T-bet.
Nature
Levine AG,Mendoza A,Hemmers S,Moltedo B,Niec RE,Schizas M,Hoyos BE,Putintseva EV,Chaudhry A,Dikiy S,Fujisawa S,Chudakov DM,Treuting PM,Rudensky AY
47-5961 was used in Flow cytometry/Cell sorting to demonstrate that T-bet+ Treg cells have an essential immunosuppressive function.
Thu Jun 15 00:00:00 EDT 2017
Intestinal Epithelial and Intraepithelial T Cell Crosstalk Mediates a Dynamic Response to Infection.
Cell
Hoytema van Konijnenburg DP,Reis BS,Pedicord VA,Farache J,Victora GD,Mucida D
47-5961 was used in Flow cytometry/Cell sorting to investigate the nature of intestinal intraepithelial lymphocyte responses to luminal microbes.
Thu Nov 02 00:00:00 EDT 2017
A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia.
Cancer cell
Robles-Valero J,Lorenzo-Martín LF,Menacho-Márquez M,Fernández-Pisonero I,Abad A,Camós M,Toribio ML,Espinosa L,Bigas A,Bustelo XR
Published figure using TCR beta monoclonal antibody (Product # 47-5961-82) in Flow Cytometry
Mon Nov 13 00:00:00 EST 2017
1810011o10 Rik Inhibits the Antitumor Effect of Intratumoral CD8+ T Cells through Suppression of Notch2 Pathway in a Murine Hepatocellular Carcinoma Model.
Frontiers in immunology
Dai K,Huang L,Huang YB,Chen ZB,Yang LH,Jiang YA
Published figure using TCR beta monoclonal antibody (Product # 47-5961-82) in Flow Cytometry
Wed Nov 20 00:00:00 EST 2019
mTORC2 regulates multiple aspects of NKT-cell development and function.
European journal of immunology
Sklarz T,Guan P,Gohil M,Cotton RM,Ge MQ,Haczku A,Das R,Jordan MS
47-5961 was used in Flow cytometry/Cell sorting to define the molecular pathway and role of Rictor in regulating invariant NKT-cell fate.
Wed Mar 01 00:00:00 EST 2017
Targeted genome editing restores T cell differentiation in a humanized X-SCID pluripotent stem cell disease model.
Scientific reports
Alzubi J,Pallant C,Mussolino C,Howe SJ,Thrasher AJ,Cathomen T
Published figure using TCR beta monoclonal antibody (Product # 47-5961-82) in Flow Cytometry
Fri Sep 29 00:00:00 EDT 2017
IL-27R signaling controls myeloid cells accumulation and antigen-presentation in atherosclerosis.
Scientific reports
Peshkova IO,Fatkhullina AR,Mikulski Z,Ley K,Koltsova EK
47-5961 was used in Flow cytometry/Cell sorting to study the role of IL-27R in controlling myeloid cell accumulation and activation in atherosclerosis.
Tue May 23 00:00:00 EDT 2017
Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche.
Cell
Clever D,Roychoudhuri R,Constantinides MG,Askenase MH,Sukumar M,Klebanoff CA,Eil RL,Hickman HD,Yu Z,Pan JH,Palmer DC,Phan AT,Goulding J,Gattinoni L,Goldrath AW,Belkaid Y,Restifo NP
47-5961 was used in Flow cytometry/Cell sorting to find that T-cell-intrinsic expression of the oxygen-sensing prolyl-hydroxylase proteins is required to maintain local tolerance against innocuous antigens in the lung but powerfully licenses colonization by circulating tumor cells.
Thu Aug 25 00:00:00 EDT 2016
Exploiting a host-commensal interaction to promote intestinal barrier function and enteric pathogen tolerance.
Science immunology
Pedicord VA,Lockhart AAK,Rangan KJ,Craig JW,Loschko J,Rogoz A,Hang HC,Mucida D
47-5961 was used in Flow cytometry/Cell sorting to demonstrate that specific factors from commensal bacteria can improve host barrier function and limit the pathogenesis of distinct enteric infections.
Thu Sep 01 00:00:00 EDT 2016
NKT sublineage specification and survival requires the ubiquitin-modifying enzyme TNFAIP3/A20.
The Journal of experimental medicine
Drennan MB,Govindarajan S,Verheugen E,Coquet JM,Staal J,McGuire C,Taghon T,Leclercq G,Beyaert R,van Loo G,Lambrecht BN,Elewaut D
47-5961 was used in Flow cytometry/Cell sorting to show that negative regulation of TCR signalling during NKT development controls the differentiation and survival of NKT1 and NKT2 cells.
Mon Sep 19 00:00:00 EDT 2016
Hypoxia-Inducible Factor-2α Limits Natural Killer T Cell Cytotoxicity in Renal Ischemia/Reperfusion Injury.
Journal of the American Society of Nephrology : JASN
Zhang J,Han C,Dai H,Hou J,Dong Y,Cui X,Xu L,Zhang M,Xia Q
Published figure using TCR beta monoclonal antibody (Product # 47-5961-82) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2016
Environmental and Genetic Activation of Hypothalamic BDNF Modulates T-cell Immunity to Exert an Anticancer Phenotype.
Cancer immunology research
Xiao R,Bergin SM,Huang W,Slater AM,Liu X,Judd RT,Lin ED,Widstrom KJ,Scoville SD,Yu J,Caligiuri MA,Cao L
Published figure using TCR beta monoclonal antibody (Product # 47-5961-82) in Flow Cytometry
Wed Jun 01 00:00:00 EDT 2016
Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1.
Nature communications
Ishikawa E,Kosako H,Yasuda T,Ohmuraya M,Araki K,Kurosaki T,Saito T,Yamasaki S
Published figure using TCR beta monoclonal antibody (Product # 47-5961-82) in Flow Cytometry
Tue Sep 27 00:00:00 EDT 2016
CCR7 Controls Thymus Recirculation, but Not Production and Emigration, of Foxp3(+) T Cells.
Cell reports
Cowan JE,McCarthy NI,Anderson G
47-5961 was used in Flow cytometry/Cell sorting to investigate CCR7 and Rag2pGFP levels during Treg development, showing that CCR7 controls thymus recirculation, but not production and emigration, of Foxp3(+) T cells.
Tue Feb 09 00:00:00 EST 2016
Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4.
Nature communications
Gomez-Rodriguez J,Meylan F,Handon R,Hayes ET,Anderson SM,Kirby MR,Siegel RM,Schwartzberg PL
47-5961 was used in Flow cytometry/Cell sorting to investigate the role of IL-9 in allergic asthma and autoimmunity, showing that Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4.
Thu Mar 03 00:00:00 EST 2016
Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt.
Nature medicine
Wilson JE,Petrucelli AS,Chen L,Koblansky AA,Truax AD,Oyama Y,Rogers AB,Brickey WJ,Wang Y,Schneider M,Mühlbauer M,Chou WC,Barker BR,Jobin C,Allbritton NL,Ramsden DA,Davis BK,Ting JP
47-5961 was used in Flow cytometry/Cell sorting to demonstrate that Akt inhibitors could be used to treat AIM2-deficient human cancers.
Sat Aug 01 00:00:00 EDT 2015
MHC-mismatched mixed chimerism augments thymic regulatory T-cell production and prevents relapse of EAE in mice.
Proceedings of the National Academy of Sciences of the United States of America
Wu L,Li N,Zhang M,Xue SL,Cassady K,Lin Q,Riggs AD,Zeng D
Published figure using TCR beta monoclonal antibody (Product # 47-5961-82) in Flow Cytometry
Tue Dec 29 00:00:00 EST 2015
A novel Cd8-cis-regulatory element preferentially directs expression in CD44hiCD62L+ CD8+ T cells and in CD8αα+ dendritic cells.
Journal of leukocyte biology
Sakaguchi S,Hombauer M,Hassan H,Tanaka H,Yasmin N,Naoe Y,Bilic I,Moser MA,Hainberger D,Mayer H,Seiser C,Bergthaler A,Taniuchi I,Ellmeier W
47-5961 was used in Flow cytometry/Cell sorting to identify a novel Cd8 enhancer that directs expression in CD44(hi)CD62L(+) CD8(+) T cells, including innate-like and antigen-specific effector/memory CD8(+) T cells and in CD8αα(+) DCs.
Wed Apr 01 00:00:00 EDT 2015
Invariant NKT cells require autophagy to coordinate proliferation and survival signals during differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Pei B,Zhao M,Miller BC,Véla JL,Bruinsma MW,Virgin HW,Kronenberg M
47-5961 was used in Flow cytometry/Cell sorting to examine the effect of a disrupting autophagy on the differentiation of iNKT cells, showing that they require autophagy to coordinate proliferation and survival.
Mon Jun 15 00:00:00 EDT 2015
Leptin receptor signaling in T cells is required for Th17 differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Reis BS,Lee K,Fanok MH,Mascaraque C,Amoury M,Cohn LB,Rogoz A,Dallner OS,Moraes-Vieira PM,Domingos AI,Mucida D
47-5961 was used in Flow cytometry/Cell sorting to show that leptin receptor signalling in T cells is required for Th17 differentiation.
Mon Jun 01 00:00:00 EDT 2015
Antibiotics in neonatal life increase murine susceptibility to experimental psoriasis.
Nature communications
Zanvit P,Konkel JE,Jiao X,Kasagi S,Zhang D,Wu R,Chia C,Ajami NJ,Smith DP,Petrosino JF,Abbatiello B,Nakatsukasa H,Chen Q,Belkaid Y,Chen ZJ,Chen W
47-5961 was used in Flow cytometry/Cell sorting to investigate the link between neonatal antibiotic-mediated imbalance in microbiota and development of experimental psoriasis.
Tue Sep 29 00:00:00 EDT 2015
Regulatory T cells promote a protective Th17-associated immune response to intestinal bacterial infection with C. rodentium.
Mucosal immunology
Wang Z,Friedrich C,Hagemann SC,Korte WH,Goharani N,Cording S,Eberl G,Sparwasser T,Lochner M
47-5961 was used in Flow cytometry/Cell sorting to study the impact of Foxp3(+) Tregs on inflammatory processes elicited by the bacterial pathogen C. rodentium, showing that Tregs promote a protective Th17-associated immune response.
Sat Nov 01 00:00:00 EDT 2014
Administration of anti-CD20 mAb is highly effective in preventing but ineffective in treating chronic graft-versus-host disease while preserving strong graft-versus-leukemia effects.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
Johnston HF,Xu Y,Racine JJ,Cassady K,Ni X,Wu T,Chan A,Forman S,Zeng D
47-5961 was used in Flow cytometry/Cell sorting to indicate that administration of anti-CD20 mAb before signs of cGVHD can prevent induction of autoimmune-like cGVHD while preserving a GVL effect.
Fri Aug 01 00:00:00 EDT 2014
Differential requirement for CCR4 and CCR7 during the development of innate and adaptive αβT cells in the adult thymus.
Journal of immunology (Baltimore, Md. : 1950)
Cowan JE,McCarthy NI,Parnell SM,White AJ,Bacon A,Serge A,Irla M,Lane PJ,Jenkinson EJ,Jenkinson WE,Anderson G
47-5961 was used in Flow cytometry/Cell sorting to identify novel roles for CCR7 during intrathymic T cell development, highlighting its importance in enabling multiple αβT cell lineages to access the thymic medulla.
Fri Aug 01 00:00:00 EDT 2014
Interleukin-4 regulates eomesodermin in CD8+ T cell development and differentiation.
PloS one
Carty SA,Koretzky GA,Jordan MS
47-5961 was used in Flow cytometry/Cell sorting to investigate the signaling pathways required for IL-4 induction of Eomes and CD8(+) innate-like lymphocyte markers in murine CD8SP thymocytes and peripheral CD8(+) T cells.
Thu May 21 00:00:00 EDT 2015
Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4⁺ T cell immunity.
Nature immunology
Reis BS,Rogoz A,Costa-Pinto FA,Taniuchi I,Mucida D
Published figure using TCR beta monoclonal antibody (Product # 47-5961-82) in Flow Cytometry
Fri Mar 01 00:00:00 EST 2013
The thymic medulla is required for Foxp3+ regulatory but not conventional CD4+ thymocyte development.
The Journal of experimental medicine
Cowan JE,Parnell SM,Nakamura K,Caamano JH,Lane PJ,Jenkinson EJ,Jenkinson WE,Anderson G
47-5961 was used in Flow cytometry/Cell sorting to demonstrate a differential requirement for the thymic medulla in relation to CD4 conventional and Foxp3(+) thymocyte lineages.
Mon Apr 08 00:00:00 EDT 2013
Generation of both cortical and Aire(+) medullary thymic epithelial compartments from CD205(+) progenitors.
European journal of immunology
Baik S,Jenkinson EJ,Lane PJ,Anderson G,Jenkinson WE
47-5961 was used in Flow cytometry/Cell sorting to reveal an unexpected overlap in the phenotypic properties of bipotent TECs with their lineage-restricted counterparts.
Fri Mar 01 00:00:00 EST 2013
Chronic follicular bronchiolitis requires antigen-specific regulatory T cell control to prevent fatal disease progression.
Journal of immunology (Baltimore, Md. : 1950)
Schmitt EG,Haribhai D,Jeschke JC,Co DO,Ziegelbauer J,Yan K,Iwakura Y,Mishra MK,Simpson P,Salzman NH,Williams CB
47-5961 was used in Flow cytometry/Cell sorting to create and characterize a new model of autoimmune lung inflammation that targets the medium and small airways.
Sun Dec 01 00:00:00 EST 2013
Nod2 activates NF-kB in CD4+ T cells but its expression is dispensable for T cell-induced colitis.
PloS one
Zanello G,Goethel A,Forster K,Geddes K,Philpott DJ,Croitoru K
47-5961 was used in Flow cytometry/Cell sorting to determine that Nod2 is functional in murine CD4(+) T cells, but unnecessary for the regulation of colitis.
Thu Jul 31 00:00:00 EDT 2014
The RAG2 C-terminus and ATM protect genome integrity by controlling antigen receptor gene cleavage.
Nature communications
Chaumeil J,Micsinai M,Ntziachristos P,Roth DB,Aifantis I,Kluger Y,Deriano L,Skok JA
47-5961 was used in Flow cytometry/Cell sorting to reveal a direct mechanism for generating inter-locus rearrangements of antigen-receptor genes.
Thu Feb 27 00:00:00 EST 2014
Interferon γ-induced intratumoral expression of CXCL9 alters the local distribution of T cells following immunotherapy with Listeria monocytogenes.
Oncoimmunology
Guirnalda P,Wood L,Goenka R,Crespo J,Paterson Y
47-5961 was used in Flow cytometry/Cell sorting to conclude that the administration of monocytogenes-based anticancer vaccines regulates TH1 chemokine responses.
Thu Aug 01 00:00:00 EDT 2013
Higher-order looping and nuclear organization of Tcra facilitate targeted rag cleavage and regulated rearrangement in recombination centers.
Cell reports
Chaumeil J,Micsinai M,Ntziachristos P,Deriano L,Wang JM,Ji Y,Nora EP,Rodesch MJ,Jeddeloh JA,Aifantis I,Kluger Y,Schatz DG,Skok JA
47-5961 was used in Flow cytometry/Cell sorting to show that higher-order loop formation is a deciding factor of directed RAG targeting and genome stability maintenance.
Thu Feb 21 00:00:00 EST 2013
Nuclear export of histone deacetylase 7 during thymic selection is required for immune self-tolerance.
The EMBO journal
Kasler HG,Lim HW,Mottet D,Collins AM,Lee IS,Verdin E
47-5961 was used in Flow cytometry/Cell sorting to examine the effect of blocking TCR-dependent nuclear export of HDAC7 during thymic selection, showing that HDAC7 is required for immune self-tolerance.
Wed Nov 28 00:00:00 EST 2012
Developmentally regulated availability of RANKL and CD40 ligand reveals distinct mechanisms of fetal and adult cross-talk in the thymus medulla.
Journal of immunology (Baltimore, Md. : 1950)
Desanti GE,Cowan JE,Baik S,Parnell SM,White AJ,Penninger JM,Lane PJ,Jenkinson EJ,Jenkinson WE,Anderson G
47-5961 was used in Flow cytometry/Cell sorting to study how multiple hemopoietic cell types regulate mTEC development through differential provision of RANKL/CD40L during ontogeny, revealing molecular differences in foetal and adult hemopoietic cross-talk.
Sat Dec 15 00:00:00 EST 2012
Vaccination with immunotherapeutic Listeria monocytogenes induces IL-17(+) γδ T cells in a murine model for HPV associated cancer.
Oncoimmunology
Guirnalda PD,Paterson Y
47-5961 was used in Flow cytometry/Cell sorting to investigate the role of IL-17 in Listeria based immunotherapy.
Sat Sep 01 00:00:00 EDT 2012
Lymphoma-like T cell infiltration in liver is associated with increased copy number of dominant negative form of TGFβ receptor II.
PloS one
Zhang W,Tsuda M,Yang GX,Tsuneyama K,He XS,Ansari AA,Ridgway WM,Coppel RL,Lian ZX,Leung PS,Gershwin ME
47-5961 was used in Flow cytometry/Cell sorting to further define the processes underlying the development of lymphoma-like T cell infiltration.
Tue Jun 25 00:00:00 EDT 2013
Development of a nanoparticulate formulation of retinoic acid that suppresses Th17 cells and upregulates regulatory T cells.
Self/nonself
Capurso NA,Look M,Jeanbart L,Nowyhed H,Abraham C,Craft J,Fahmy TM
47-5961 was used in Flow cytometry/Cell sorting to develop a nanoparticulate drug delivery platform from poly(lactic-co-glycolic acid) capable of encapsulating and releasing retinoic acid.
Fri Oct 01 00:00:00 EDT 2010
