Invitrogen

TCR beta Monoclonal Antibody (H57-597), FITC

TCR beta Antibody in Flow Cytometry (Flow)

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TCR beta Antibody (MA5-17651) in Flow

Flow cytometric analysis of Splenic T cells (A) and Thymus cells (B) stained using anti-TCR alpha/beta Monoclonal Antibody (Product # MA5-17651) at a 0.2 µg/10^6 cells dilution. The Isotype control was a FITC Hamster IgG

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产品信息

MA5-17651

应用

建议稀释比

已发表文章

流式细胞分析 (Flow)

0.2 µg/1x10^6 cells

查看6篇已发表文章 6篇已发表文章

其他PubMed (Misc)

查看8篇已发表文章 8篇已发表文章

产品规格

种属反应

Mouse

已发表种属

Mouse

宿主/亚型

Armenian hamster / IgG

分类

Monoclonal

类型

Antibody

克隆号

H57-597

抗原

Affinity-purified DO-11.10 TCR

偶联物

FITC FITC FITC

激发/发射光谱

498/517 nm 查看光谱

形式

Liquid

浓度

0.1 mg/mL

纯化类型

Protein G

保存液

PBS with 4-5mg/mL BSA

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2539041

靶标信息

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease (ref5). T Cell and TCR Diversity Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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Product References

IL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-2.

Nature communications

Jandl C,Liu SM,Cañete PF,Warren J,Hughes WE,Vogelzang A,Webster K,Craig ME,Uzel G,Dent A,Stepensky P,Keller B,Warnatz K,Sprent J,King C

MA5-17651 was used in Flow cytometry/Cell sorting to identify a mechanism by which IL-21 reinforces humoural immunity by influencing the phenotype of T follicular cells to limit their expansion.

Fri Mar 17 00:00:00 EDT 2017

CXCL16-positive dendritic cells enhance invariant natural killer T cell-dependent IFNγ production and tumor control.

Oncoimmunology

Veinotte L,Gebremeskel S,Johnston B

MA517651 was used in flow cytometry to study the contribution of CXCR6/CXCL16 interactions in glycolipid-dependent invariant natural killer cell activation and tumor control

Wed Jun 01 00:00:00 EDT 2016

Invariant NKT cells suppress CD8(+) T-cell-mediated allergic contact dermatitis independently of regulatory CD4(+) T cells.

The Journal of investigative dermatology

Goubier A,Vocanson M,Macari C,Poyet G,Herbelin A,Nicolas JF,Dubois B,Kaiserlian D

MA5-17651 was used in Flow cytometry/Cell sorting to study the role of invariant natural killer T cells as potent downregulators of CD8 T cell-mediated contact hypersensitivity.

Mon Apr 01 00:00:00 EDT 2013

Thymic alterations in mice deficient for the SNARE protein VAMP8/endobrevin.

Cell and tissue research

Kanwar N,Fayyazi A,Backofen B,Nitsche M,Dressel R,von Mollard GF

MA5-17651 was used in flow cytometry to elucidate the role of VAMP8 in the thymus

Sat Nov 01 00:00:00 EDT 2008

Respiratory Francisella tularensis live vaccine strain infection induces Th17 cells and prostaglandin E2, which inhibits generation of gamma interferon-positive T cells.

Infection and immunity

Woolard MD,Hensley LL,Kawula TH,Frelinger JA

MA5-17651 was used in flow cytometry to investigate how the route of inoculation with Francisella tularensis influences the primary acute adaptive immune response

Sun Jun 01 00:00:00 EDT 2008

Transgenic TCR expression: comparison of single chain with full-length receptor constructs for T-cell function.

Cancer gene therapy

Zhang T,He X,Tsang TC,Harris DT

MA5-17651 was used in flow cytometry to investigate the use of three-domain single-chain T-cell receptors

Thu Jul 01 00:00:00 EDT 2004

Involvement of p38 mitogen-activated protein kinase in different stages of thymocyte development.

Blood

Hsu SC,Wu CC,Han J,Lai MZ

MA5-17651 was used in flow cytometry to suggest that p38 is involved in positive selection of T cells.

Sat Feb 01 00:00:00 EST 2003

Differential in vivo persistence of two subsets of memory phenotype CD8 T cells defined by CD44 and CD122 expression levels.

Journal of immunology (Baltimore, Md. : 1950)

Walzer T,Arpin C,Beloeil L,Marvel J

MA5-17651 was used in flow cytometry to characterize two subsets of mouse CD8 T cells.

Fri Mar 15 00:00:00 EST 2002

Increased p300 expression inhibits glucocorticoid receptor-T-cell receptor antagonism but does not affect thymocyte positive selection.

Molecular and cellular biology

Yu CT,Feng MH,Shih HM,Lai MZ

MA5-17651 was used in flow cytometry to test if T-cell-specific expression of p300 alters GR-TCR cross talk between thymocytes.

Mon Jul 01 00:00:00 EDT 2002

Candida albicans infection enhances immunosuppression induced by cyclophosphamide by selective priming of suppressive myeloid progenitors for NO production.

Cellular immunology

Angulo I,Jiménez-Díaz MB,García-Bustos JF,Gargallo D,de las Heras FG,Muñoz-Fernández MA,Fresno M

MA5-17651 was used in flow cytometry to examine the T cell responses in cyclophosphamide-treated mice after systemic infection with Candida albicans.

Wed Feb 05 00:00:00 EST 2003

IL-18 enhances IL-4 production by ligand-activated NKT lymphocytes: a pro-Th2 effect of IL-18 exerted through NKT cells.

Journal of immunology (Baltimore, Md. : 1950)

Leite-De-Moraes MC,Hameg A,Pacilio M,Koezuka Y,Taniguchi M,Van Kaer L,Schneider E,Dy M,Herbelin A

MA5-17651 was used in flow cytometry to investigate the effect of IL-18 on NKT cells.

Mon Jan 15 00:00:00 EST 2001

Nitric oxide-producing CD11b(+)Ly-6G(Gr-1)(+)CD31(ER-MP12)(+) cells in the spleen of cyclophosphamide-treated mice: implications for T-cell responses in immunosuppressed mice.

Blood

Angulo I,de las Heras FG,García-Bustos JF,Gargallo D,Muñoz-Fernández MA,Fresno M

MA5-17651 was used in flow cytometry to study T-cell unresponsiveness in cyclophosphamide treated mice.

Sat Jan 01 00:00:00 EST 2000

Downmodulation of the inflammatory response to bacterial infection by gammadelta T cells cytotoxic for activated macrophages.

The Journal of experimental medicine

Egan PJ,Carding SR

MA5-17651 was used in flow cytometry to propose that gammadelta T cells eliminating activated macrophages after infection with an intracellular pathogen.

Mon Jun 19 00:00:00 EDT 2000

Identification of an early T cell progenitor for a pathway of T cell maturation in the bone marrow.

Proceedings of the National Academy of Sciences of the United States of America

Dejbakhsh-Jones S,Strober S

MA5-17651 was used in flow cytometry to identify a rare population of cells in the adult mouse bone marrow that generates CD4(+) and CD8(+) TCRalphabeta(+) T cells.

Tue Dec 07 00:00:00 EST 1999

生物信息学

蛋白别名: bTCR; FLJ22602; MGC117436; MGC22624; MGC23964; MGC71411; t-cell antigen receptor; T-cell receptor; TCR beta; Tcra; TCRbeta; TCRD; TRA

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基因别名: TCRbeta; Tib

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Entrez Gene ID: (Mouse) 21577

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TCR beta Monoclonal Antibody (H57-597), FITC

TCR beta Antibody (MA5-17651) in Flow

产品信息

MA5-17651

流式细胞分析 (Flow)

其他PubMed (Misc)

种属反应

已发表种属

宿主/亚型

分类

类型

克隆号

抗原

偶联物

激发/发射光谱

形式

浓度

纯化类型

保存液

内含物

保存条件

运输条件

RRID

靶标信息

How to use the Panel Builder

生物信息学

性能保障

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