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Invitrogen
TENM2 Polyclonal Antibody
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TENM2 Antibody (PA5-47638) in IHC (F)
Immunohistochemical analysis of TENM2 in immersion fixed frozen sections of embryonic mouse brain. Samples were incubated in TENM2 polyclonal antibody (Product # PA5-47638) using a dilution of 10 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Sheep HRP-DAB Cell & Tissue Staining Kit (brown) and counterstained with hematoxylin (blue). Specific staining was localized to neurons in dorsal root gang... View More
产品信息
PA5-47638
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Sheep
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E. coli-derived recombinant human Teneurin-2 Met1-Lys183
偶联物
形式
Lyophilized
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
In direct ELISAs, approximately 15% cross-reactivity with recombinant human (rh) Teneurin-3 is observed, and less than 4% cross-reactivity with rhTeneurin-1 is observed.
Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL.
靶标信息
Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Induces homophilic cell-cell adhesion. May function as a cellular signal transducer. Isoform 2: Acts as a ligand of the ADGRL1 receptor. Mediates axon guidance and heterophilic cell-cell adhesion. {ECO:0000269 PubMed:21724987}. Ten-2 intracellular domain: Induces gene transcription inhibition. {ECO:0000250}.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Neurestin; neurestin alpha; odd Oz/ten-m homolog 2; odz, odd Oz/ten-m homolog 2; Protein Odd Oz/ten-m homolog 2; Ten-2; Ten-m2; Tenascin-M2; Teneurin transmembrane protein 2; Teneurin-2
基因别名: KIAA1127; Lasso; ODZ2; Odz3; Ten-2; TEN-M2; TENM2; TNM2
UniProt ID: (Human) Q9NT68, (Rat) Q9R1K2
Entrez Gene ID: (Human) 57451, (Rat) 117242, (Mouse) 23964
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
axon guidance
central nervous system development
single organismal cell-cell adhesion
calcium-mediated signaling using intracellular calcium source
positive regulation of filopodium assembly
self proteolysis
regulation of transcription, DNA-templated
cell adhesion
signal transduction
