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Invitrogen
TESK2 Polyclonal Antibody
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TESK2 Antibody (PA5-110474) in WB
Western blot analysis of TESK2 in extracts of various cell lines. Samples were incubated with TESK2 Polyclonal antibody (Product # PA5-110474) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 1s.
产品信息
PA5-110474
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 302-571 of human TESK2 (NP_009101.2).
偶联物
形式
Liquid
浓度
1.155 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: FVEIGKTLEE ILSRLQEEEQ ERDRKLQPTA RGLLEKAPGV KRLSSLDDKI PHKSPCPRRT IWLSRSQSDI FSRKPPRTVS VLDPYYRPRD GAARTPKVNP FSARQDLMGG KIKFFDLPSK SVISLVFDLD APGPGTMPLA DWQEPLAPPI RRWRSLPGSP EFLHQEACPF VGREESLSDG PPPRLSSLKY RVKEIPPFRA SALPAAQAHE AMDCSILQEE NGFGSRPQGT SPCPAGASEE MEVEERPAGS TPATFSTSGI GLQTQGKQDG
靶标信息
TESK2 or testis-specific kinase 2 is a serine/threonine protein kinase that contains an N-terminal protein kinase domain and belongs to the TESK subgroup of the LIMK/TESK family of protein kinases. The kinase domain of TESK2 is structurally similar to the kinase domain of testis-specific protein kinase-1 and the LIM motif-containing protein kinases (LIMKs). TESK2 is predominantly expressed in testis and prostate and plays an important role in spermatogenesis. TESK2 phosphorylates cofilin specifically at Ser-3 and induces formation of actin stress fibers and focal adhesions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Dual specificity testis-specific protein kinase 2; Testicular protein kinase 2
基因别名: TESK2
UniProt ID: (Human) Q96S53, (Mouse) Q8VCT9
Entrez Gene ID: (Human) 10420, (Mouse) 230661
protein kinase activity
protein serine/threonine kinase activity
protein serine/threonine/tyrosine kinase activity
protein tyrosine kinase activity
protein binding
ATP binding
metal ion binding
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
