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Invitrogen
TET3 Polyclonal Antibody
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Product Details
PA5-96735
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein (or fragment)
Conjugate
Form
Liquid
Concentration
2.28 mg/mL
Amount
228 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: Jurkat, HT-29, SKOV3, Mouse lung, Rat thymus; Cellular Location: Cytoplasm, Nucleus
Immunogen sequence: GFQDKLWNPM KGEEGRIPAA GASQLDRAWQ SFGLPLGSSE KLFGALKSEE KLWDPFSLEE GPAEEPPSKG AVKEEKGGGG AEEEEEELWS DSEHNFLDEN
Target Information
TET3, a member of the ten-eleven-translocation (TET) family of genes, is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine and is most abundantly expressed in hematopoietic cells. Unlike the related TET2 protein, mutations in TET3 have not been observed in any myeloid malignancies. TET3 has been shown to be involved in the demethylation of zygotic DNA before the first mitosis and has been suggested to be involved in the epigenetic reprogramming of the zygotic paternal DNA following natural fertilization and may also contribute to somatic cell nuclear reprogramming during animal cloning.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: KIAA0401; Methylcytosine dioxygenase TET3; MGC22014; probable methylcytosine dioxygenase TET3; putative methylcytosine dioxygenase; ten-eleven translocation 3; Tet methylcytosine deoxygenase 3 isoform; tet methylcytosine dioxygenase 3; tet oncogene family member 3
Gene Aliases: B430006D22Rik; BC037432; BEFAHRS; CXXC10; D230004J03Rik; hCG_40738; KIAA0401; TET3
UniProt ID: (Human) O43151, (Mouse) Q8BG87
Entrez Gene ID: (Human) 200424, (Rat) 680576, (Mouse) 194388
RNA polymerase II core promoter proximal region sequence-specific DNA binding
DNA binding
protein binding
zinc ion binding
methyl-CpG binding
oxidoreductase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
metal ion binding
dioxygenase activity
methylcytosine dioxygenase activity
molecular_function
protein O-linked glycosylation
biological_process
DNA demethylation of male pronucleus
positive regulation of transcription from RNA polymerase II promoter
oxidation-reduction process
DNA demethylation
histone H3-K4 trimethylation
multicellular organism development
chromatin modification
chromatin organization
regulation of gene expression
positive regulation of macromolecule biosynthetic process
regulation of gene expression, epigenetic
hypomethylation of CpG island
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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