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TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauA domain of TFIIIC that binds boxA DNA promoter sites of tRNA and similar genes. TFC4 is the TFIIIB-assembling subunit of TFIIIC and essential for viability.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: PCF1; TFIIIC 131 kDa subunit; Transcription factor C subunit 4; Transcription factor tau 131 kDa subunit
基因别名: PCF1; TFC4; YGR047C
UniProt ID: (Baker's yeast) P33339
Entrez Gene ID: (Baker's yeast) 852938