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Invitrogen
TGF beta-1,2 (Nisevokitug Biosimilar) Recombinant Human Monoclonal Antibody
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产品信息
MA562559
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG2, lambda1
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A/G
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
TGFB-1 (Transforming Growth Factor Beta 1) and TGFB-2 (Transforming Growth Factor Beta 2) are members of the TGFB superfamily of cytokines, which play critical roles in cellular processes including proliferation, differentiation, and migration, as well as immune responses. Both TGFB-1 and TGFB-2 are synthesized as precursor proteins that are proteolytically processed to release the mature, active cytokine. They signal through a heteromeric complex of serine/threonine kinase receptors, leading to the phosphorylation and activation of SMAD transcription factors, which in turn regulate the expression of target genes. TGFB-1 is predominantly involved in immune regulation, wound healing, and fibrosis. It has potent immunosuppressive properties and is critical for the maintenance of immune homeostasis. TGFB-2, while sharing many functions with TGFB-1, has distinct roles in the development of the nervous system and the regulation of cellular differentiation in various tissues. Both cytokines are involved in pathophysiological conditions, such as cancer, where they can promote tumor growth and metastasis by modulating the tumor microenvironment.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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