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          Disclaimer

          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • TGF beta-2 Antibodies

          Invitrogen

          TGF beta-2 Monoclonal Antibody (220ct16.4.3.1)

          1 篇参考文献
          查看其他12个TGF beta-2抗体

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          说明书
          实验方案
          问题与答案
          技术支持
          说明书
          实验方案
          问题与答案
          技术支持

          Cite TGF beta-2 Monoclonal Antibody (220ct16.4.3.1)

          • 抗体检测数据 (7)
          TGF beta-2 Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.
          TGF beta-2 Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.

          图: 1 / 7

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          TGF beta-2 Antibody (MA5-37505) in ICC/IF

          Immunocytochemistry/Immunofluorescent analysis of TGF beta-2 in A549 cells using the TGF beta-2 Monoclonal Antibody (Product # MA5-37505) at a dilution of 1:10-1:50, followed by Alexa Fluor® 488-conjugated goat anti-mouse lgG (green).DAPI was used to stain the cell nuclear (blue). {{ $ctrl.currentElement.advancedVerification.fullName }} 验证信息 View more
          已发表图片由___提供 benchsci-logo
          PMID: {{$ctrl.currentElement.benchSciPubmedId}}
          查看产品

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          TGF beta-2 Antibody in Immunocytochemistry (ICC/IF)
          TGF beta-2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          TGF beta-2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          TGF beta-2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          TGF beta-2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          TGF beta-2 Antibody in Western Blot (WB)
          TGF beta-2 Antibody in Western Blot (WB)

          产品信息

          MA5-37505

          应用
          建议稀释比
          已发表文章

          免疫印迹 (WB)

          1:500-1:1,000
          查看1篇已发表文章 1篇已发表文章

          免疫组化(石蜡) (IHC (P))

          1:10-1:50
          -

          免疫细胞化学 (ICC/IF)

          1:10-1:50
          -
          产品规格

          种属反应

          Human

          已发表种属

          Mouse

          宿主/亚型

          Mouse / IgG1, kappa

          分类

          Monoclonal

          类型

          Antibody

          克隆号

          220ct16.4.3.1

          抗原

          TGFB2 recombinant protein

          偶联物

          Unconjugated Unconjugated Unconjugated

          形式

          Liquid

          浓度

          0.43 mg/mL

          纯化类型

          Protein G

          保存液

          PBS, pH 7.4

          内含物

          0.09% sodium azide

          保存条件

          Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

          运输条件

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2897437

          靶标信息

          Transforming Growth Factor (TGF) betas mediate many cell to cell interactions that occur during embryonic development. Three TGF betas have been identified in mammals. TGF beta 1, TGF beta 2 and TGF beta 3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecule. The TGF beta polypeptides are multifunctional; capable of influencing cell proliferation, differentiation, and other functions in a wide range of cell types. Transformed, as well as nonneoplastic tissues, release transforming growth factors; and essentially all mammalian cells possess a specific TGF receptor. The multi modal nature of TGF beta is seen in its ability to stimulate or inhibit cellular proliferation. In general, cells of mesenchymal origin appear to be stimulated by TGF beta whereas cells of epithelial or neuroectodermal origin are inhibited by the peptide. TGF beta 1, TGF beta 2, and TGF beta 1.2 appear to be equivalent in biological activity, although there does appear to be differences in binding to certain types of receptors. TGF beta 2 is produced by many cell types and has been found in the highest concentration in porcine platelets and mammalian bone. Latent TGF beta 2 is the prominent isoform found in body fluids such as amniotic fluid, breast milk, and the aqueous and vitreous humor of the eye.

          仅用于科研。不用于诊断过程。未经明确授权不得转售。

          生物信息学

          蛋白别名: BSC-1 cell growth inhibitor; Cetermin; G-TSF; Glioblastoma-derived T-cell suppressor factor; polyergin; prepro-transforming growth factor beta-2; TGFB; TGFβ2; Transforming growth factor; Transforming growth factor beta-2 proprotein; transforming growth factor, beta 2

          查看更多 收起

          基因别名: LDS4; TGF-beta2; TGFB2

          查看更多 收起

          UniProt ID: (Human) P61812

          查看更多 收起

          Entrez Gene ID: (Human) 7042

          查看更多 收起

          功能
          beta-amyloid binding receptor signaling protein serine/threonine kinase activity receptor binding type II transforming growth factor beta receptor binding cytokine activity transforming growth factor beta receptor binding protein binding growth factor activity type III transforming growth factor beta receptor binding protein homodimerization activity protein heterodimerization activity growth factor
          参与通路
          cell morphogenesis cartilage condensation angiogenesis eye development response to hypoxia epithelial to mesenchymal transition hair follicle development blood vessel remodeling platelet degranulation heart morphogenesis outflow tract septum morphogenesis membranous septum morphogenesis heart valve morphogenesis atrioventricular valve morphogenesis pulmonary valve morphogenesis endocardial cushion morphogenesis cardiac right ventricle morphogenesis ventricular trabecula myocardium morphogenesis endocardial cushion fusion atrial septum primum morphogenesis protein phosphorylation cell cycle arrest transforming growth factor beta receptor signaling pathway SMAD protein import into nucleus cell-cell signaling axon guidance salivary gland morphogenesis heart development cell death cell proliferation positive regulation of cell proliferation negative regulation of cell proliferation glial cell migration response to wounding embryo development cardioblast differentiation positive regulation of gene expression negative regulation of gene expression positive regulation of epithelial cell migration negative regulation of alkaline phosphatase activity positive regulation of epithelial to mesenchymal transition positive regulation of pathway-restricted SMAD protein phosphorylation negative regulation of macrophage cytokine production positive regulation of phosphatidylinositol 3-kinase signaling cell growth cell migration signal transduction by protein phosphorylation hemopoiesis collagen fibril organization positive regulation of cell growth negative regulation of cell growth neutrophil chemotaxis hair follicle morphogenesis activation of protein kinase activity response to progesterone positive regulation of stress-activated MAPK cascade regulation of transforming growth factor beta2 production regulation of actin cytoskeleton organization positive regulation of cell adhesion mediated by integrin ascending aorta morphogenesis wound healing dopamine biosynthetic process odontogenesis response to drug catagen uterine wall breakdown positive regulation of neuron apoptotic process cell-cell junction organization positive regulation of integrin biosynthetic process positive regulation of ossification positive regulation of cell cycle positive regulation of heart contraction negative regulation of Ras protein signal transduction somatic stem cell division embryonic digestive tract development neuron fate commitment neuron development generation of neurons negative regulation of epithelial cell proliferation positive regulation of protein secretion negative regulation of immune response positive regulation of immune response positive regulation of cell division positive regulation of catagen positive regulation of cardioblast differentiation cardiac muscle cell proliferation cardiac epithelial to mesenchymal transition face morphogenesis pathway-restricted SMAD protein phosphorylation SMAD protein signal transduction ventricular septum morphogenesis atrial septum morphogenesis negative regulation of cartilage development pharyngeal arch artery morphogenesis positive regulation of activation-induced cell death of T cells positive regulation of extracellular matrix disassembly extrinsic apoptotic signaling pathway positive regulation of protein localization to nucleus regulation of apoptotic process involved in outflow tract morphogenesis regulation of complement-dependent cytotoxicity positive regulation of GTP binding negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
          It has to be done as per old AB suggested Products section.
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