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Invitrogen
TGF beta-3 Polyclonal Antibody
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产品信息
PA5-148446
产品规格
种属反应
All
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
S. frugiperda insect ovarian cell line Sf 21-derived recombinant chicken TGF-beta3 and recombinant human TGF-beta3, Ala301-Ser412 (Tyr340Phe)
偶联物
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Protein A/G
保存液
PBS with trehalose
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute at 1 mg/mL in sterile PBS.
靶标信息
Transforming growth factor beta 3 (TGF beta 3) is the third member of the transforming growth factor family of cytokines, which also includes TGF beta 1 and beta 2. These cytokines are secreted in precursor form consisting of a bioactive C-terminal domain attached to an N-terminal domain known as latency associated protein (LAP). Cleavage of LAP results in the mature protein, which functions as a disulfide-linked homodimer. As with all members of the family, TGF beta 3 is highly conserved across species, with mouse and human TGF beta 3 demonstrating 100% sequence homology and cross-species activity.The members of this family can be expressed by most cell types and exert pleiotropic effects, which include the suppression of B- and T-cell effector activity, mediation of tissue healing, and suppression of tumor proliferation. The promotion of CD4+CD25+ T-cell expansion is a newly discovered function of the TGF beta cytokines, and indicates an important role in the protection against autoimmunity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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