TGF-beta (Transforming Growth Factor beta) Monoclonal Antibody (1D11.16.8)

type II transforming growth factor beta receptor binding cytokine activity transforming growth factor beta receptor binding protein binding growth factor activity enzyme binding type I transforming growth factor beta receptor binding type III transforming growth factor beta receptor binding deubiquitinase activator activity identical protein binding protein serine/threonine kinase activator activity macromolecular complex binding antigen binding beta-amyloid binding receptor binding protein homodimerization activity transforming growth factor beta binding glycoprotein binding protein heterodimerization activity protein N-terminus binding receptor signaling protein serine/threonine kinase activity growth factor

negative regulation of transcription from RNA polymerase II promoter cell morphogenesis vasculogenesis ureteric bud development response to hypoxia morphogenesis of a branching structure cell activation epithelial to mesenchymal transition neural tube closure regulation of sodium ion transport sprouting angiogenesis chondrocyte differentiation columnar/cuboidal epithelial cell maturation hematopoietic progenitor cell differentiation connective tissue replacement involved in inflammatory response wound healing adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains tolerance induction to self antigen negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target heart valve morphogenesis aortic valve morphogenesis protein export from nucleus ATP biosynthetic process phosphate-containing compound metabolic process cellular calcium ion homeostasis apoptotic process inflammatory response transforming growth factor beta receptor signaling pathway Notch signaling pathway negative regulation of neuroblast proliferation salivary gland morphogenesis endoderm development heart development female pregnancy cell proliferation positive regulation of cell proliferation negative regulation of cell proliferation germ cell migration response to xenobiotic stimulus response to wounding response to glucose gene expression regulation of gene expression positive regulation of vascular endothelial growth factor production positive regulation of gene expression negative regulation of gene expression negative regulation of extracellular matrix disassembly positive regulation of epithelial to mesenchymal transition macrophage derived foam cell differentiation positive regulation of fibroblast migration negative regulation of macrophage cytokine production oligodendrocyte development positive regulation of microglia differentiation regulation of striated muscle tissue development neural tube development hyaluronan catabolic process T cell differentiation negative regulation of ossification negative regulation of cell growth osteoclast differentiation regulation of cell migration positive regulation of cell migration mammary gland development organ regeneration membrane protein intracellular domain proteolysis positive regulation of protein complex assembly positive regulation of exit from mitosis response to estradiol response to progesterone regulation of interleukin-23 production negative regulation of interleukin-17 production positive regulation of interleukin-17 production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production receptor catabolic process positive regulation of superoxide anion generation mononuclear cell proliferation regulation of actin cytoskeleton organization positive regulation of collagen biosynthetic process response to vitamin D response to laminar fluid shear stress response to immobilization stress myofibroblast differentiation T cell proliferation T cell activation regulation of cell proliferation negative regulation of T cell proliferation regulation of protein import into nucleus positive regulation of protein import into nucleus odontogenesis of dentin-containing tooth positive regulation of odontogenesis myelination T cell homeostasis positive regulation of apoptotic process positive regulation of vascular permeability positive regulation of I-kappaB kinase/NF-kappaB signaling surfactant homeostasis proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of MAPK cascade positive regulation of blood vessel endothelial cell migration negative regulation of blood vessel endothelial cell migration regulatory T cell differentiation cell-cell junction organization response to ethanol regulation of regulatory T cell differentiation positive regulation of regulatory T cell differentiation negative regulation of cell differentiation positive regulation of cell differentiation negative regulation of fat cell differentiation negative regulation of myoblast differentiation positive regulation of epidermal growth factor receptor signaling pathway negative regulation of cell cycle negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter muscle cell cellular homeostasis positive regulation of fibroblast proliferation lung alveolus development positive regulation of isotype switching to IgA isotypes lymph node development digestive tract development negative regulation of skeletal muscle tissue development positive regulation of smooth muscle cell proliferation inner ear development epithelial cell proliferation positive regulation of epithelial cell proliferation negative regulation of epithelial cell proliferation positive regulation of protein secretion positive regulation of inflammatory response negative regulation of phagocytosis defense response to fungus negative regulation of T cell activation positive regulation of chemotaxis positive regulation of cellular component organization positive regulation of smooth muscle cell differentiation positive regulation of multicellular organismal process positive regulation of protein metabolic process negative regulation of release of sequestered calcium ion into cytosol neuron apoptotic process regulation of cell cycle positive regulation of cell division positive regulation of protein kinase B signaling ventricular cardiac muscle tissue morphogenesis phospholipid homeostasis canonical Wnt signaling pathway regulation of blood vessel remodeling face morphogenesis frontal suture morphogenesis positive regulation of SMAD protein import into nucleus bronchiole development mammary gland branching involved in thelarche branch elongation involved in mammary gland duct branching regulation of branching involved in mammary gland duct morphogenesis regulation of cartilage development retina vasculature development in camera-type eye connective tissue development Langerhans cell differentiation negative regulation of biomineral tissue development regulation of enamel mineralization lens fiber cell differentiation positive regulation of ERK1 and ERK2 cascade response to cholesterol cellular response to mechanical stimulus cellular response to glucose stimulus cellular response to growth factor stimulus cellular response to low-density lipoprotein particle stimulus cellular response to hypoxia cellular response to ionizing radiation cellular response to dexamethasone stimulus cellular response to transforming growth factor beta stimulus positive regulation of mononuclear cell migration odontoblast differentiation stem cell proliferation extracellular matrix assembly positive regulation of branching involved in ureteric bud morphogenesis positive regulation of canonical Wnt signaling pathway extrinsic apoptotic signaling pathway liver regeneration cellular response to virus transforming growth factor beta receptor superfamily signaling pathway negative regulation of hyaluronan biosynthetic process positive regulation of protein localization to nucleus positive regulation of extracellular matrix assembly response to salt positive regulation of mesenchymal stem cell proliferation regulation of miRNA transcription negative regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of pri-miRNA transcription from RNA polymerase II promoter negative regulation of protein localization to plasma membrane positive regulation of vasculature development positive regulation of STAT cascade regulation of epithelial to mesenchymal transition involved in endocardial cushion formation cellular response to acetaldehyde cellular response to insulin-like growth factor stimulus embryonic liver development negative regulation of cell-cell adhesion mediated by cadherin positive regulation of chemokine (C-X-C motif) ligand 2 production positive regulation of endothelial cell apoptotic process positive regulation of primary miRNA processing positive regulation of stem cell proliferation positive regulation of cardiac muscle cell differentiation MAPK cascade negative regulation of protein phosphorylation positive regulation of protein phosphorylation cell cycle arrest mitotic cell cycle checkpoint epidermal growth factor receptor signaling pathway common-partner SMAD protein phosphorylation SMAD protein complex assembly positive regulation of peptidyl-threonine phosphorylation positive regulation of pathway-restricted SMAD protein phosphorylation cell migration regulation of transforming growth factor beta receptor signaling pathway negative regulation of cell-cell adhesion positive regulation of bone mineralization lipopolysaccharide-mediated signaling pathway positive regulation of cellular protein metabolic process positive regulation of peptidyl-serine phosphorylation positive regulation of protein dephosphorylation positive regulation of MAP kinase activity protein kinase B signaling positive regulation of phosphatidylinositol 3-kinase activity ossification involved in bone remodeling negative regulation of mitotic cell cycle pathway-restricted SMAD protein phosphorylation regulation of SMAD protein import into nucleus cellular response to organic cyclic compound positive regulation of NAD+ ADP-ribosyltransferase activity positive regulation of transcription regulatory region DNA binding protein phosphorylation positive regulation of mammary gland epithelial cell proliferation regulation of binding regulation of DNA binding positive regulation of transdifferentiation skeletal system development cartilage condensation blood vessel development eye development kidney development hair follicle development blood vessel remodeling heart morphogenesis outflow tract septum morphogenesis membranous septum morphogenesis outflow tract morphogenesis atrioventricular valve morphogenesis pulmonary valve morphogenesis endocardial cushion morphogenesis cardiac right ventricle morphogenesis ventricular trabecula myocardium morphogenesis endocardial cushion fusion atrial septum primum morphogenesis neural retina development activation-induced cell death of T cells axon guidance sensory organ development glial cell migration male gonad development embryo development ending in birth or egg hatching cardioblast differentiation positive regulation of epithelial cell migration striated muscle tissue development negative regulation of angiogenesis signaling hemopoiesis extracellular matrix organization collagen fibril organization positive regulation of cell growth embryonic limb morphogenesis neutrophil chemotaxis epithelial cell differentiation hair follicle morphogenesis positive regulation of stress-activated MAPK cascade regulation of transforming growth factor beta2 production positive regulation of cell adhesion mediated by integrin ascending aorta morphogenesis wound healing dopamine biosynthetic process odontogenesis uterine wall breakdown regulation of apoptotic process positive regulation of neuron apoptotic process positive regulation of integrin biosynthetic process positive regulation of Notch signaling pathway positive regulation of cell cycle positive regulation of heart contraction negative regulation of Ras protein signal transduction somatic stem cell division embryonic digestive tract development neuron fate commitment neuron development generation of neurons positive regulation of immune response regulation of timing of catagen positive regulation of catagen positive regulation of cardioblast differentiation cardiac muscle cell proliferation uterus development cardiac epithelial to mesenchymal transition ventricular septum morphogenesis atrial septum morphogenesis negative regulation of cartilage development pharyngeal arch artery morphogenesis secondary palate development positive regulation of cardiac epithelial to mesenchymal transition positive regulation of activation-induced cell death of T cells positive regulation of extracellular matrix disassembly extrinsic apoptotic signaling pathway in absence of ligand regulation of apoptotic process involved in outflow tract morphogenesis regulation of extracellular matrix organization regulation of complement-dependent cytotoxicity substantia propria of cornea development pericyte cell differentiation cranial skeletal system development negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation positive regulation of extrinsic apoptotic signaling pathway in absence of ligand cell death negative regulation of alkaline phosphatase activity positive regulation of phosphatidylinositol 3-kinase signaling signal transduction by protein phosphorylation activation of protein kinase activity response to drug positive regulation of ossification SMAD protein signal transduction in utero embryonic development negative regulation of neuron apoptotic process positive regulation of filopodium assembly positive regulation of stress fiber assembly detection of hypoxia negative regulation of vascular smooth muscle cell proliferation positive regulation of occluding junction disassembly protein import into nucleus, translocation regulation of cell growth SMAD protein import into nucleus aging negative regulation of DNA replication response to radiation defense response to fungus, incompatible interaction response to organic substance response to organic cyclic compound cell growth evasion or tolerance of host defenses by virus lung development positive regulation of histone deacetylation positive regulation of histone acetylation myeloid dendritic cell differentiation regulation of MAPK cascade negative regulation of immune response positive regulation of NF-kappaB transcription factor activity negative regulation of gene silencing by miRNA positive regulation of cell cycle arrest regulation of actin cytoskeleton reorganization regulation of miRNA metabolic process CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment defense response skeletal muscle tissue development organ morphogenesis regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation growth cell development T-helper 17 cell lineage commitment cardiac left ventricle morphogenesis intracellular signal transduction catagen negative regulation of apoptotic process response to estrogen negative regulation of keratinocyte differentiation embryonic neurocranium morphogenesis response to cold response to organonitrogen compound thyroid gland development hindbrain development pancreas development response to retinoic acid response to cytokine activation of MAPK activity negative regulation of transforming growth factor beta receptor signaling pathway regulation of epithelial cell differentiation regulation of endothelial cell differentiation positive regulation of DNA replication regulation of epithelial cell proliferation palate development embryo development