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Abnova
TGIF Monoclonal Antibody (1D12)
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产品信息
H00007050-M01
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
1D12
抗原
TGIF (NP_003235, 163 a.a. approximately 272 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
0.5-1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Sandwich ELISA (Recombinant protein).
Immunogen sequence: PGSVLARPSV ICHTTVTALK DVPFSLCQSV GVGQNTDIQQ IAAKNFTDTS LMYPEDTCKS GPSTNTQSGL FNTPPPTPPD LNQDFSGFQL LVDVALKRAA EMELQAKLTA
靶标信息
TGIF is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 5'-TG-3'-interacting factor 1; Homeobox protein TGIF1; TALE homeobox TG-interacting factor; TGFB-induced factor homeobox 1; transforming growth factor-beta-induced factor
基因别名: HPE4; TGIF; TGIF1
UniProt ID: (Human) Q15583
Entrez Gene ID: (Human) 7050
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
transcription corepressor activity
protein binding
co-SMAD binding
homeodomain transcription factor
