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Invitrogen
TGM2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-95256
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence at the N-terminus of human TGM2 (7-34aa LERCDLELETNGRDHHTADLCREKLVVR).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
500 µg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: Rat Liver Tissue, Rat Ovary Tissue, HELA whole cell. IHC: mouse spleen tissue, rat spleen tissue, human intestinal cancer tissue, human mammary cancer tissue IHC-F: mouse spleen tissue, rat spleen tissue, human placenta tissue.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
靶标信息
Transglutaminase (TGase) catalyses the crosslink of proteins by forming e-(g-glutamyl) lysine isopeptide bonds and requires the binding of Ca2+ for its activity. In mammals, eight distinct TGase isoenzymes have been identified. Tissue transglutaminase (tTGase), also known as TGase 2, has four distinct domains: N-terminal b-sandwich, catalytic core and two C-terminal b-barrel domains. tTGase may have a role in cell death, cell proliferation, cell differentiation, and receptor-mediated endocytosis. In the Alzheimer's disease brain, the elevated tTGase activity is manifested by polymerization of a number of proteins, including Ab peptide, b-amyloid precursor protein and the tau protein, with formation of neurofibrillary tangles.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: C polypeptide; G alpha h; G-ALPHA-h; GNAH; Isopeptidase TGM2; Protein G alpha(h); Protein G(h); Protein-glutamine deamidase TGM2; Protein-glutamine dopaminyltransferase TGM2; Protein-glutamine gamma-glutamyltransferase 2; Protein-glutamine histaminyltransferase TGM2; Protein-glutamine noradrenalinyltransferase TGM2; Protein-glutamine serotonyltransferase TGM2; protein-glutamine-gamma-glutamyltransferase; RP5-1054A22.2; TG C; TG(C); TG2; TGase 2; TGase C; TGase II; TGase-2; TGase-H; TGC; Tissue transglutaminase; Tissue type transglutaminase; tissue-type transglutaminase; Transglutaminase 2 C polypeptide; transglutaminase 2, C polypeptide; transglutaminase C; Transglutaminase II; Transglutaminase-2; tTG
基因别名: G[a]h; TG2; TGase2; TgaseII; Tgm2; tTG; tTGas
UniProt ID: (Rat) Q9WVJ6, (Mouse) P21981
Entrez Gene ID: (Rat) 56083, (Mouse) 21817
blood vessel remodeling
phospholipase C-activating G-protein coupled receptor signaling pathway
isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine
negative regulation of endoplasmic reticulum calcium ion concentration
positive regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
apoptotic cell clearance
positive regulation of cell adhesion
positive regulation of smooth muscle cell proliferation
positive regulation of inflammatory response
protein homooligomerization
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
positive regulation of mitochondrial calcium ion concentration
branching involved in salivary gland morphogenesis
salivary gland cavitation
G-protein coupled receptor signaling pathway
peptide cross-linking
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