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产品信息
MA5-12739
应用
建议稀释比
已发表文章
产品规格
种属反应
Dog,
Guinea pig,
Human,
Rabbit
已发表种属
C. elegans,
Chicken,
Dog,
Hamster,
Human,
Mouse,
Non-human primate,
Pig,
Rat
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
CUB 7402
抗原
Purified guinea pig liver TGase II
偶联物
形式
Liquid
浓度
0.02 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.4, with 0.2% BSA
内含物
0.09% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
MA5-12739 targets Transglutaminase II in IF, IHC (P), IP, and WB applications and shows reactivity with Canine, Guinea Pig, Human, and Rabbit samples.
The MA5-12739 immunogen is purified guinea pig liver TGase II.
靶标信息
Transglutaminase (TGase) catalyses the crosslink of proteins by forming e-(g-glutamyl) lysine isopeptide bonds and requires the binding of Ca2+ for its activity. In mammals, eight distinct TGase isoenzymes have been identified. Tissue transglutaminase (tTGase), also known as TGase 2, has four distinct domains: N-terminal b-sandwich, catalytic core and two C-terminal b-barrel domains. tTGase may have a role in cell death, cell proliferation, cell differentiation, and receptor-mediated endocytosis. In the Alzheimer's disease brain, the elevated tTGase activity is manifested by polymerization of a number of proteins, including Ab peptide, b-amyloid precursor protein and the tau protein, with formation of neurofibrillary tangles.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: C polypeptide, protein-glutamine-gamma-glutamyltransferase; Erythrocyte transglutaminase; G alpha h; G(h); G-ALPHA-h; GNAH; Heart G alpha(h); hhG alpha(h); Isopeptidase TGM2; Protein G alpha(h); Protein-glutamine deamidase TGM2; Protein-glutamine dopaminyltransferase TGM2; Protein-glutamine gamma-glutamyltransferase 2; Protein-glutamine histaminyltransferase TGM2; Protein-glutamine noradrenalinyltransferase TGM2; Protein-glutamine serotonyltransferase TGM2; RP5-1054A22.2; TG(C); TG2; TGase C; TGase H; TGase II; TGase-2; TGase-H; Tissue transglutaminase; Tissue type transglutaminase; transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase); Transglutaminase 2 C polypeptide; transglutaminase 2, C polypeptide; Transglutaminase C; Transglutaminase H; Transglutaminase II; Transglutaminase-2; tTG
基因别名: TG(C); TGC; TGM2
UniProt ID: (Human) P21980
Entrez Gene ID: (Dog) 485867, (Rabbit) 100352148, (Human) 7052, (Guinea pig) 100379228
phospholipase C-activating G-protein coupled receptor signaling pathway
peptide cross-linking
negative regulation of endoplasmic reticulum calcium ion concentration
positive regulation of apoptotic process
apoptotic cell clearance
positive regulation of cell adhesion
positive regulation of mitochondrial calcium ion concentration
branching involved in salivary gland morphogenesis
salivary gland cavitation
