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THEM2 Polyclonal Antibody
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FIGURE: 1 / 3
THEM2 Antibody (600-401-FD9) in ICC/IF
Immunofluorescence Microscopy of THEM2 antibody. Tissue: human liver tissue. Fixation: 0.5% PFA. Antigen retrieval: not required. Primary antibody: THEM2 antibody at 20 µg/mL for 1 hr at RT. Secondary antibody: Fluorescein rabbit secondary antibody at 1:10,000 for 45 min at RT. Localization: THEM2 is secreted into the extracellular space. Staining: THEM2 as red fluorescent signal.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
600-401-FD9
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Anti-THEM2 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 17 amino acid synthetic peptide near the C-terminus of human THEM2.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
THEM2, also known as ACOT13, belongs to the hotdog-fold superfamily and possesses thioesterase activity, with greater activity observed with longer chain acyl-CoAs such as myristoyl- and palmitoyl-CoA. THEM2 is highly expressed in several tissues such as heart, kidney, liver and brain and has been shown to be co-localized with beta-tubulin on microtubules. THEM2 interacts with StarD, a protein that plays a key role in fatty acid metabolism, and the addition of StarD to THEM2 increased its catalytic activity, suggesting that THEM2 plays a significant role in the metabolism of fatty acids. At least two isoforms of THEM2 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Acyl-CoA thioesterase 13; Acyl-coenzyme A thioesterase 13; Hotdog-fold thioesterase superfamily member 2; Palmitoyl-CoA hydrolase; THEM2; Thioesterase superfamily member 2
Gene Aliases: 0610006O17Rik; ACOT13; HT012; PNAS-27; THEM2
UniProt ID: (Mouse) Q9CQR4
Entrez Gene ID: (Rat) 291135, (Mouse) 66834
acyl-CoA hydrolase activity
CoA hydrolase activity
hydrolase activity
2-oxoglutaryl-CoA thioesterase activity
2,4,4-trimethyl-3-oxopentanoyl-CoA thioesterase activity
3-isopropylbut-3-enoyl-CoA thioesterase activity
glutaryl-CoA hydrolase activity
esterase
hydrolase
metabolite interconversion enzyme
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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