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Bethyl Laboratories
THOC5 Polyclonal Antibody
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THOC5 Antibody (A302-120A) in WB
Detection of human and mouse THOC5 by western blot (h&m) and immunoprecipitation (h). Samples: Whole cell lysate from HeLa (5, 15 and 50 µg for WB; 1 mg for IP, 20% of IP loaded), HEK293T (T; 50 µg) and mouse NIH 3T3 (M; 50 µg) cells. Antibodies: Affinity purified rabbit anti-THOC5 antibody (Product # A302-120A) used for WB at 0.04 µg/mL (A) and 0.4 µg/mL (B) and used for IP at 3 µg/mg lysate. THOC5 was also immunoprecipitated by rabbit anti-THOC5 antibody A302-119A, which recognizes an upstream epitope. Detection: Chemiluminescence with e... View More
产品信息
A302-120A
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Region between residue 300 and 325 of Human THO complex 5.
偶联物
形式
Liquid
浓度
0.20 mg/mL
纯化类型
Antigen affinity chromatography
保存液
TBS, pH 7.0 to 8.0, with 0.1% BSA
内含物
0.09% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Mouse, X. laevis, X. tropicalis, Chicken and Bovine
靶标信息
Component the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between THOC4 and the cap-binding protein NCBP1. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction beteen KSHV ORF57 protein and THOC4. UAP56 functions as a bridge between THOC4 and the THO complex. THOC5 in conjunction with THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA. May be involved in the differentiation of granulocytes and adipocytes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Fms-interacting protein; fSAP79; Functional spliceosome-associated protein 79; hTREX90; NF2/meningioma region protein pK1.3; Placental protein 39.2; PP39.2; THO complex subunit 5
基因别名: C22orf19; Fmip; fSAP79; KIAA0983; PK1.3; THOC5
UniProt ID: (Human) Q13769
Entrez Gene ID: (Human) 8563
termination of RNA polymerase II transcription
RNA export from nucleus
mRNA export from nucleus
RNA splicing
monocyte differentiation
mRNA 3'-end processing
positive regulation of DNA-templated transcription, elongation
viral mRNA export from host cell nucleus
primitive hemopoiesis
negative regulation of DNA damage checkpoint
