Invitrogen

THRA Polyclonal Antibody

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43 篇参考文献
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THRA Polyclonal Antibody

产品信息

PA1-211A

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:200
查看26篇已发表文章 26篇已发表文章

免疫组化 (IHC)

-
查看5篇已发表文章 5篇已发表文章

免疫组化（石蜡） (IHC (P))

1:20-1:100
查看2篇已发表文章 2篇已发表文章

免疫细胞化学 (ICC/IF)

1:10-1:200
查看5篇已发表文章 5篇已发表文章

免疫电镜技术 (IM)

-
查看1篇已发表文章 1篇已发表文章

凝胶阻滞分析 (EMSA)

1:10
查看2篇已发表文章 2篇已发表文章

亲和纯化 (AP)

-
查看1篇已发表文章 1篇已发表文章

其他PubMed (Misc)

-
查看1篇已发表文章 1篇已发表文章
产品规格

种属反应

Chicken, Human, Mouse, Rat

已发表种属

C. elegans, Human, Mouse, Non-human primate, Rat, Sheep, Xenopus

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic Peptide: E(403) V F E D Q E V(410)
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

Conc. Not Determined

保存液

whole serum, PBS

内含物

0.05% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_325811

产品详细信息

PA1-211A detects thyroid receptor (TR) from human, mouse, rat and chicken samples. This antibody does not detect TRv alpha -2 or TR beta-1.

PA1-211A has been successfully used in Western blot, IHC-P, ICC/IF and gel shift procedures. By Western blot, this antibody detects a ~48 kDa protein representing recombinant human TR alpha-1 expressed in E. coli. Gel shift experiments show that this product reacts with TR alpha-1 homodimers and TR alpha-1/retinoic X receptor (RXR) heterodimers.

PA1-211A immunizing peptide corresponds to amino acid residues 403-410 from human TR alpha-1. This sequence is completely conserved between human and rat TR alpha-1.

靶标信息

The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 1; c-erb-A protein; c-erb-A thyroid hormone receptor; c-erbA-1; C-erbA-alpha; c-erbA-alpha2; c-erbAalpha; c-erbAalpha2; cerbA protein; cerbAalpha; E ERB-T-1; EAR-7; ERBA ALPHA; ERBA related 7; ERBA-related 7; MGC000261; MGC43240; Nuclear receptor subfamily 1 group A member 1; Oncogene ERBA; Thyroid hormone receptor alpha; thyroid hormone receptor alpha 1; thyroid hormone receptor alpha 1 (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 1 formerly ERBA1); thyroid hormone receptor beta; thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian); thyroid normone nuclear receptor alpha variant 1; TR; TR alpha 1; TR alpha 1+2; TR alpha 2; triiodothyronine receptor; unnamed protein product; V-erbA-related protein 7

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基因别名: 6430529J03Rik; AR7; AW259572; c-ERBA-1; C-erba-alpha; CHNG6; EAR7; ERB-T-1; ERBA; ERBA1; NR1A1; Rvr; T3R[a]; T3Ralpha; THRA; THRA1; THRA2

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UniProt ID: (Chicken) P04625, (Human) P10827, (Mouse) P63058, (Rat) P63059

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Entrez Gene ID: (Chicken) 396251, (Human) 7067, (Mouse) 21833, (Rat) 81812

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功能
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding zinc ion binding thyroid hormone binding sequence-specific double-stranded DNA binding transcription regulatory region sequence-specific DNA binding steroid receptor RNA activator RNA binding transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding steroid hormone receptor activity thyroid hormone receptor activity transcription factor binding TBP-class protein binding protein domain specific binding chromatin DNA binding protein complex binding protein homodimerization activity transcription regulatory region DNA binding intronic transcription regulatory region DNA binding protein heterodimerization activity DNA binding single-stranded RNA binding sequence-specific DNA binding metal ion binding protein dimerization activity C4 zinc finger nuclear receptor DNA-binding transcription factor zinc finger transcription factor gene-specific transcriptional regulator
参与通路
negative regulation of transcription from RNA polymerase II promoter thyroid hormone mediated signaling pathway hormone-mediated signaling pathway cell differentiation positive regulation of transcription from RNA polymerase II promoter cartilage condensation ossification kidney development liver development regulation of thyroid hormone mediated signaling pathway regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter brain development learning or memory regulation of heart contraction female courtship behavior response to cold positive regulation of myotube differentiation negative regulation of RNA polymerase II transcriptional preinitiation complex assembly erythrocyte differentiation adrenal gland development intracellular receptor signaling pathway thyroid gland development response to nutrient levels regulation of myeloid cell apoptotic process response to drug cytoplasmic sequestering of transcription factor steroid hormone mediated signaling pathway negative regulation of sequence-specific DNA binding transcription factor activity negative regulation of transcription, DNA-templated positive regulation of female receptivity digestive tract development embryonic organ development regulation of lipid catabolic process Type I pneumocyte differentiation negative regulation of DNA-templated transcription, initiation transcription, DNA-templated regulation of transcription, DNA-templated organ morphogenesis lung development
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