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Abnova
TIAM2 Polyclonal Antibody, MaxPab™
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产品信息
H00026230-B01P
产品规格
种属反应
Human,
Rat
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
TIAM2 (NP_001010927, 1 a.a. approximately 626 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MEGPRENQDP PPRPLARHLS DADRLRKVIQ ELVDTEKSYV KDLSCLFELY LEPLQNETFL TQDEMESLFG SLPEMLEFQK VFLETLEDGI SASSDFNTLE TPSQFRKLLF SLGGSFLYYA DHFKLYSGFC ANHIKVQKVL ERAKTDKAFK AFLDARNPTK QHSSTLESYL IKPVQRVLKY PLLLKELVSL TDQESEEHYH LTEALKAMEK VASHINEMQK IYEDYGTVFD QLVAEQSGTE KEVTELSMGE LLMHSTVSWL NPFLSLGKAR KDLELTVFVF KRAVILVYKE NCKLKKKLPS NSRPAHNSTD LDPFKFRWLI PISALQVRLG NPAGTENNSI WELIHTKSEI EGRPETIFQL CCSDSESKTN IVKVIRSILR ENFRRHIKCE LPLEKTCKDR LVPLKNRVPV SAKLASSRSL KVLKNSSSNE WTGETGKGTL LDSDEGSLSS GTQSSGCPTA EGRQDSKSTS PGKYPHPGLA DFADNLIKES DILSDEDDDH RQTVKQGSPT KDIEIQFQRL RISEDPDVHP EAEQQPGPES GEGQKGGEQP KLVRGHFCPI KRKANSTKRD RGTLLKAQIR HQSLDSQSEN ATIDLNSVLE REFSVQSLTS VVSEECFYET ESHGKS
靶标信息
Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane. Activates specifically RAC1, but not CDC42 and RHOA.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Rho guanine nucleotide exchange factor TIAM2; SIF and TIAM1-like exchange factor; T-cell lymphoma invasion and metastasis 2; T-lymphoma invasion and metastasis-inducing protein 2; TIAM-2
基因别名: KIAA2016; STEF; TIAM-2; TIAM2
UniProt ID: (Human) Q8IVF5
Entrez Gene ID: (Rat) 100362710, (Human) 26230
