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产品信息
H00353376-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
TICAM2 (NP_067681.1, 1 a.a. approximately 235 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
0.5-1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MGIGKSKINS CPLSLSWGKR HSVDTSPGYH ESDSKKSEDL SLCNVAEHSN TTEGPTGKQE GAQSVEEMFE EEAEEEVFLK FVILHAEDDT DEALRVQNLL QDDFGIKPGI IFAEMPCGRQ HLQNLDDAVN GSAWTILLLT ENFLRDTWCN FQFYTSLMNS VNRQHKYNSV IPMRPLNNPL PRERTPFALQ TINALEEESR GFPTQVERIF QESVYKTQQT IWKETRNMVQ RQFIA
靶标信息
TRAM, or TRIF-related adaptor molecule (TICAM2), plays an essential role in the MyD88-independent signaling of TLR4. The functional absence of TRAM in vascular endothelial cells restricts TLR4 signaling to MyD88-dependent pathway. Overexpression of TRAM cDNA in endothelial cells reconstituted LPS-induced Trif-dependent NF-kB activation and cxcl10 promoter activity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cytoplasmic adaptor; MyD88-4; NF-kappa-B-activating protein 502; Putative NF-kappa-B-activating protein 502; TAG; TICAM-2; TIR domain-containing adapter molecule 2; toll-like receptor adaptor molecule 2; Toll-like receptor adaptor protein 3; toll/interleukin-1 receptor (TIR) domain-containing adapter protein; Toll/interleukin-1 receptor domain-containing protein; TRIF-related adapter molecule; TRIF-related adaptor molecule
基因别名: MyD88-4; TICAM-2; TICAM2; TIRAP3; TIRP; TRAM
UniProt ID: (Human) Q86XR7
Entrez Gene ID: (Human) 353376
MyD88-independent toll-like receptor signaling pathway
inflammatory response
I-kappaB kinase/NF-kappaB signaling
positive regulation of interferon-gamma production
positive regulation of interleukin-6 production
negative regulation of MyD88-independent toll-like receptor signaling pathway
toll-like receptor 4 signaling pathway
positive regulation of toll-like receptor 4 signaling pathway
TRIF-dependent toll-like receptor signaling pathway
TRAM-dependent toll-like receptor 4 signaling pathway
positive regulation of I-kappaB kinase/NF-kappaB signaling
innate immune response
necroptotic process
response to interleukin-12
cellular response to lipopolysaccharide
positive regulation of chemokine (C-C motif) ligand 5 production
apoptotic signaling pathway
positive regulation of interleukin-18-mediated signaling pathway
