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Invitrogen
TICAM2 Monoclonal Antibody (757712)
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产品信息
MA5-61425
产品规格
种属反应
Mouse
宿主/亚型
Rat
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
757712
抗原
E. coli-derived recombinant mouse TRAM/TICAM2, Met1-Ala232
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
纯化类型
Protein A/G
保存液
PBS with 5% trehalose
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with sterile PBS to a final concentration of 0.5 mg/mL.
靶标信息
TRAM, or TRIF-related adaptor molecule (TICAM2), plays an essential role in the MyD88-independent signaling of TLR4. The functional absence of TRAM in vascular endothelial cells restricts TLR4 signaling to MyD88-dependent pathway. Overexpression of TRAM cDNA in endothelial cells reconstituted LPS-induced Trif-dependent NF-kB activation and cxcl10 promoter activity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: TAG; TICAM-2; TIR domain-containing adapter molecule 2; TIR domain-containing adapter protein; Toll-interleukin I receptor domain (TIR)-containing adaptor molecule (TICAM) 2; Toll/interleukin-1 receptor domain-containing protein; TRIF-related adapter molecule; TRIF-related adapter molecule TRAM; TRIF-related adaptor molecule
基因别名: B430113A10; TICAM-2; Ticam2; Tirp; TRAM; Trif
UniProt ID: (Mouse) Q8BJQ4
Entrez Gene ID: (Mouse) 225471
regulation of cytokine production
immune system process
inflammatory response
signal transduction
positive regulation of interferon-gamma production
positive regulation of interleukin-6 production
negative regulation of toll-like receptor 4 signaling pathway
positive regulation of toll-like receptor 4 signaling pathway
TRAM-dependent toll-like receptor 4 signaling pathway
regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of I-kappaB kinase/NF-kappaB signaling
innate immune response
regulation of interferon-beta biosynthetic process
response to interleukin-12
cellular response to lipopolysaccharide
negative regulation of chemokine (C-C motif) ligand 5 production
positive regulation of chemokine (C-C motif) ligand 5 production
positive regulation of interleukin-18-mediated signaling pathway
