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Invitrogen
TIMP2 Recombinant Rabbit Monoclonal Antibody (5P3T3)
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TIMP2 Antibody (MA5-51199) in WB
Western blot analysis of TIMP2 in extracts of various cell lines. Samples were incubated with TIMP2 Recombinant monoclonal antibody (Product # MA5-51199) using a dilution of 1:1,000 followed by HRP Goat Anti-Rabbit IgG (H+L) secondary antibody at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-51199
产品规格
种属反应
Human,
Mouse,
Non-human primate,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
5P3T3
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 120-220 of human TIMP2.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.93 mg/mL
规格
93 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: VSLDVGGKKE YLIAGKAEGD GKMHITLCDF IVPWDTLSTT QKKSLNHRYQ MGCECKITRC PMIPCYISSP DECLWMDWVT EKNINGHQAK FFACIKRSDG S
靶标信息
TIMP-1 and TIMP-2 are inhibitory enzymes of matrix metalloproteinase family, and are thought to be of great importance in the maintenance of connective tissue integrity. TIMP-2 shows the highest binding affinity to both the latent (pro) and active forms of 72 kDa Type IV collagenase (also known as MMP-2 or gelatinase A). It also has affinity for the active form of 92 kDa Type IV collagenase (also known as MMP-9 or gelatinase B). TIMP-2 inhibits the proteolytic invasiveness of tumor cells and normal placental trophoblast cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CSC-21K; Metalloproteinase inhibitor 2; TIMP 2; TIMP-2; tissue inhibitor of metalloproteinase 2; Tissue inhibitor of metalloproteinases 2
基因别名: D11Bwg1104e; Timp-2; TIMP2
UniProt ID: (Rat) P30121
Entrez Gene ID: (Rat) 29543, (Mouse) 21858
spermatogenesis
central nervous system development
aging
negative regulation of cell proliferation
response to hormone
negative regulation of endopeptidase activity
regulation of cAMP metabolic process
regulation of Rap protein signal transduction
response to cytokine
response to drug
positive regulation of catalytic activity
negative regulation of catalytic activity
regulation of MAPK cascade
positive regulation of MAPK cascade
regulation of neuron differentiation
positive regulation of neuron differentiation
positive regulation of adenylate cyclase activity
negative regulation of proteolysis
negative regulation of mitotic cell cycle
negative regulation of Ras protein signal transduction
negative regulation of membrane protein ectodomain proteolysis
cellular response to organic substance
negative regulation of peptidase activity
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