Invitrogen

TIRAP Polyclonal Antibody

3个已发表图片
4 篇参考文献
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说明书
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问题与答案
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说明书
实验方案
问题与答案
技术支持
TIRAP Polyclonal Antibody

产品信息

PA5-88657

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
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免疫细胞化学 (ICC/IF)

1:50-1:200
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酶联免疫吸附实验 (ELISA)

1 µg/mL
-
产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein (or fragment)
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.23 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2805059

产品详细信息

Immunogen sequence: MASSTSLPAP GSRPKKPLGK MADWFRQTLL KKPKKRPNSP ESTSSDASQP TSQDSPLPPS LSSVTSPSLP PTHASDSGSS RWSKDYDVCV CHSEEDLVAA QDLVSYLEGS TASLRCFLQL RDATPGGAIV SELCQALSSS HCRVLLITPG FLQDPWCKYQ MLQALTEAPG AEGCTIPLLS GLSRAAYPPE LRFMYYVDGR GPDGGFRQVK EAVMRYLQTL S; Positive Samples: HeLa, Mouse lung, Rat liver; Cellular Location: Cell membrane, Cytoplasm, Membrane

靶标信息

Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as TIRAP and MyD88 to activate various kinases and transcription factors. In TIRAP-deficient mice, TLR signaling in response to TLR2 ligands (using either TLR1 and TLR6 as co-receptors) is totally abolished, suggesting that MyD88 and TIRAP work together and are both required for TLR2 signaling. Furthermore, these mice are also resistant to the toxic effects of LPS and show defects in NF-βB and MAP kinase activation, suggesting that TIRAP is also involed in TLR4 signaling.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: adapter protein wyatt; Adaptor protein Wyatt; FLJ42305; HGNC:17192; MyD88 adapter-like protein; MyD88-2; OTTHUMP00000179130; TIR domain-containing adapter protein; toll-interleukin 1 receptor (TIR) domain containing adaptor protein; toll-interleukin 1 receptor (TIR) domain-containing adaptor protein; Toll-like receptor 4 adaptor protein; Toll-like receptor adaptor protein; Toll/interleukin-1 receptor domain-containing adapter protein

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基因别名: AA407980; BACTS1; C130027E04Rik; MAL; MyD88-2; TIRAP; Tlr4ap; Wyatt

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UniProt ID: (Human) P58753, (Mouse) Q99JY1

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Entrez Gene ID: (Human) 114609, (Mouse) 117149, (Rat) 680127

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功能
protein kinase C binding protein binding phosphatidylinositol-4,5-bisphosphate binding protein binding, bridging Toll-like receptor 4 binding Toll-like receptor 2 binding protein homodimerization activity protein heterodimerization activity molecular_function
参与通路
immune system process inflammatory response signal transduction cell surface receptor signaling pathway I-kappaB kinase/NF-kappaB signaling activation of JUN kinase activity response to bacterium myeloid cell differentiation positive regulation of B cell proliferation response to lipopolysaccharide regulation of interferon-beta production regulation of interleukin-15 production positive regulation of interleukin-12 production positive regulation of interleukin-15 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production positive regulation of toll-like receptor 2 signaling pathway positive regulation of toll-like receptor 3 signaling pathway positive regulation of toll-like receptor 4 signaling pathway toll-like receptor 5 signaling pathway TIRAP-dependent toll-like receptor 4 signaling pathway positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of growth of symbiont in host innate immune response regulation of innate immune response positive regulation of innate immune response positive regulation of interleukin-6 biosynthetic process positive regulation of JNK cascade defense response to Gram-positive bacterium positive regulation of NF-kappaB transcription factor activity positive regulation of ERK1 and ERK2 cascade interleukin-1-mediated signaling pathway 3'-UTR-mediated mRNA stabilization cellular response to bacterial lipopeptide cellular response to lipoteichoic acid positive regulation of neutrophil chemotaxis positive regulation of protein homodimerization activity positive regulation of chemokine (C-X-C motif) ligand 1 production positive regulation of chemokine (C-X-C motif) ligand 2 production MyD88-dependent toll-like receptor signaling pathway activation of NF-kappaB-inducing kinase activity toll-like receptor 4 signaling pathway biological_process
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