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Invitrogen
TK1 protein Recombinant Mouse Monoclonal Antibody (10C2)
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TK1 protein Antibody (MA566276) in SDS-PAGE
SDS-PAGE characterization of TK1 protein under reducing conditions. Lane M: Protein marker (kDa); Lane TK1-D: Purified TK1 protein Recombinant Monoclonal (Product # MA566276). TK1 protein showing heavy chain (~50 kDa) and light chain (~25 kDa). Gels were stained with Coomassie Brilliant Blue R-340.
产品信息
MA566276
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
10C2
抗原
Recombinant human TK1 protein.
偶联物
形式
Liquid
浓度
7.3 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Thymidine kinase 1 (TK1) is a crucial enzyme involved in the DNA synthesis pathway, specifically catalyzing the phosphorylation of thymidine to thymidine monophosphate (dTMP), which is further phosphorylated to thymidine triphosphate (dTTP). TK1 is located on chromosome 17q25.3 and is expressed predominantly during the S-phase of the cell cycle. Structurally, TK1 can form tetramers, which enhances its enzymatic activity. Functionally, TK1 is upregulated in various cancers, making it a potential biomarker for tumor diagnosis and prognosis. It plays a significant role in DNA repair, especially in p53-deficient tumor cells, by expanding the dTTP pool during recovery from DNA damage. Additionally, TK1 influences oncogenic phenotypes by promoting glycolysis through interactions with protein arginine methyltransferase 1 (PRMT1). Targeting TK1 expression is considered a promising therapeutic approach to enhance anti-tumor immunotherapy efficacy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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