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Invitrogen
TLK1 Polyclonal Antibody
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图: 1 / 4
TLK1 Antibody (720397) in ICC/IF
For immunofluorescence analysis, cells were fixed and permeabilized for detection of endogenous TLK1 using Anti- TLK1 Rabbit Polyclonal Antibody (Product # 720397, 5 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows representative cells that were stained for detection and localization of TLK1 protein (green), Panel b) is stained for nuclei (blue) using SlowFade® Gold Antifade Mountant with DAPI (Product # S36938). Panel c) repres... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
720397
产品规格
种属反应
Human
已发表种属
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptides corresponding to human TLK1 [1) aa348-aa367 2) aa107-aa122]
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2-7.4, with 30% glycerol, 0.1% BSA
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody is predicted to react with Monkey, Rabbit, Rat.
靶标信息
TLK1 or tousled-like kinase 1 is a nuclear serine/threonine kinase that is potentially involved in the regulation of chromatin assembly. TLK1 is first described in Arabidopsis. TLK1 is a novel target of the DNA damage checkpoint that is rapidly inactivated upon exposure to ionizing radiation (IR) and the inactivation is directly mediated by the S-phase DNA damage checkpoint. The suppression of TLK1 activity after double-strand breaks in the DNA, replication blockade, or low doses of ultraviolet irradiation requires ATM, NBS and CHK1. The Tousled-like kinases, first described in Arabadopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: PKU beta; PKU-beta; serine threonine protein kinase; serine/threonine protein kinase; Serine/threonine-protein kinase tousled-like 1; SNAK; SNARE protein kinase SNAK; TLK-1; TLK1B; Tousled-like kinase 1; unnamed protein product
基因别名: KIAA0137; PKU-beta; TLK1
UniProt ID: (Human) Q9UKI8
Entrez Gene ID: (Human) 9874
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