TLR4/MD-2 Complex Monoclonal Antibody (MTS510)

lipopolysaccharide binding lipopolysaccharide receptor activity protein binding coreceptor activity Toll-like receptor 4 binding beta-amyloid binding transmembrane signaling receptor activity receptor binding signaling receptor activity identical protein binding protein heterodimerization activity NAD+ nucleotidase, cyclic ADP-ribose generating receptor activity phosphatidylinositol 3-kinase binding scaffold/adaptor protein

pattern recognition receptor signaling pathway toll-like receptor signaling pathway immune system process inflammatory response cellular defense response cell surface receptor signaling pathway lipopolysaccharide-mediated signaling pathway positive regulation of lipopolysaccharide-mediated signaling pathway response to lipopolysaccharide detection of lipopolysaccharide positive regulation of tumor necrosis factor production toll-like receptor 4 signaling pathway innate immune response cellular response to lipopolysaccharide activation of innate immune response wound healing involved in inflammatory response B cell proliferation involved in immune response nitric oxide production involved in inflammatory response regulation of dendritic cell cytokine production MyD88-dependent toll-like receptor signaling pathway nitric oxide biosynthetic process phagocytosis defense response immune response signal transduction I-kappaB kinase/NF-kappaB signaling JNK cascade response to bacterium gene expression positive regulation of platelet activation positive regulation of gene expression astrocyte development microglia differentiation positive regulation of smooth muscle cell migration detection of fungus neurogenesis signal transduction involved in regulation of gene expression positive regulation of B cell proliferation regulation of tumor necrosis factor production negative regulation of interferon-gamma production negative regulation of interleukin-17 production negative regulation of interleukin-23 production negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production positive regulation of chemokine production positive regulation of interferon-alpha production positive regulation of interferon-beta production positive regulation of interferon-gamma production positive regulation of interleukin-1 beta production positive regulation of interleukin-1 production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of stress-activated MAPK cascade regulation of toll-like receptor 4 signaling pathway TRIF-dependent toll-like receptor signaling pathway cellular response to platelet-derived growth factor stimulus T-helper 1 type immune response B cell proliferation macrophage activation defense response to bacterium positive regulation of macrophage activation positive regulation of I-kappaB kinase/NF-kappaB signaling leukocyte activation MHC class II biosynthetic process positive regulation of MHC class II biosynthetic process positive regulation of nitric oxide biosynthetic process negative regulation of osteoclast differentiation positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade lymphocyte proliferation positive regulation of smooth muscle cell proliferation positive regulation of lymphocyte proliferation regulation of inflammatory response positive regulation of inflammatory response defense response to Gram-negative bacterium positive regulation of NF-kappaB transcription factor activity NK T cell activation stress-activated MAPK cascade detection of stimulus intestinal epithelial structure maintenance positive regulation of macrophage cytokine production ERK1 and ERK2 cascade negative regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade nucleotide-binding oligomerization domain containing 1 signaling pathway positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway nucleotide-binding oligomerization domain containing 2 signaling pathway positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway cellular response to lipoteichoic acid cellular response to mechanical stimulus cellular response to interferon-gamma negative regulation of cold-induced thermogenesis cellular response to oxidised low-density lipoprotein particle stimulus negative regulation of cytokine production involved in inflammatory response positive regulation of cytokine production involved in inflammatory response positive regulation of NLRP3 inflammasome complex assembly positive regulation of reactive oxygen species biosynthetic process positive regulation of cellular response to macrophage colony-stimulating factor stimulus positive regulation of matrix metallopeptidase secretion cellular response to beta-amyloid positive regulation of chemokine (C-X-C motif) ligand 2 production positive regulation of extrinsic apoptotic signaling pathway activation of MAPK activity microglial cell activation innate immune response-activating signal transduction leukotriene metabolic process response to oxidative stress activation of NF-kappaB-inducing kinase activity I-kappaB phosphorylation interferon-gamma production positive regulation of NF-kappaB import into nucleus positive regulation of tumor necrosis factor biosynthetic process positive regulation of apoptotic process positive regulation of DNA binding positive regulation of interleukin-12 biosynthetic process positive regulation of interferon-beta biosynthetic process positive regulation of interleukin-1 biosynthetic process positive regulation of interleukin-13 biosynthetic process positive regulation of interleukin-6 biosynthetic process positive regulation of interleukin-8 biosynthetic process response to ethanol mast cell activation regulation of cytokine secretion positive regulation of peptidyl-tyrosine phosphorylation positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of nitric-oxide synthase biosynthetic process regulation of sensory perception of pain response to fatty acid