TLR4/MD-2 Complex Monoclonal Antibody (MTS510)

lipopolysaccharide receptor activity protein binding coreceptor activity lipopolysaccharide binding receptor activity transmembrane signaling receptor activity phosphatidylinositol 3-kinase binding scaffold/adaptor protein

MyD88-dependent toll-like receptor signaling pathway MyD88-independent toll-like receptor signaling pathway inflammatory response cellular defense response cell surface receptor signaling pathway I-kappaB kinase/NF-kappaB signaling lipopolysaccharide-mediated signaling pathway positive regulation of lipopolysaccharide-mediated signaling pathway response to lipopolysaccharide detection of lipopolysaccharide positive regulation of tumor necrosis factor production negative regulation of MyD88-independent toll-like receptor signaling pathway toll-like receptor 4 signaling pathway TRIF-dependent toll-like receptor signaling pathway innate immune response necroptotic process apoptotic signaling pathway pattern recognition receptor signaling pathway immune system process activation of MAPK activity toll-like receptor signaling pathway B cell proliferation involved in immune response nitric oxide production involved in inflammatory response regulation of dendritic cell cytokine production immune response I-kappaB phosphorylation positive regulation of platelet activation positive regulation of gene expression astrocyte development detection of fungus positive regulation of B cell proliferation interferon-gamma production negative regulation of interferon-gamma production negative regulation of interleukin-17 production negative regulation of interleukin-23 production negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production positive regulation of chemokine production positive regulation of interferon-alpha production positive regulation of interferon-beta production positive regulation of interferon-gamma production positive regulation of interleukin-1 production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production T-helper 1 type immune response macrophage activation positive regulation of NF-kappaB import into nucleus positive regulation of tumor necrosis factor biosynthetic process defense response to bacterium positive regulation of interleukin-12 biosynthetic process positive regulation of MHC class II biosynthetic process positive regulation of interferon-beta biosynthetic process positive regulation of interleukin-8 biosynthetic process positive regulation of nitric oxide biosynthetic process negative regulation of osteoclast differentiation positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade interleukin-1 beta secretion regulation of cytokine secretion positive regulation of inflammatory response defense response to Gram-negative bacterium positive regulation of NF-kappaB transcription factor activity positive regulation of nitric-oxide synthase biosynthetic process intestinal epithelial structure maintenance positive regulation of macrophage cytokine production negative regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway cellular response to lipopolysaccharide cellular response to lipoteichoic acid cellular response to mechanical stimulus positive regulation of NLRP3 inflammasome complex assembly microglial cell activation activation of innate immune response innate immune response-activating signal transduction leukotriene metabolic process response to oxidative stress signal transduction activation of NF-kappaB-inducing kinase activity response to bacterium positive regulation of stress-activated MAPK cascade positive regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of DNA binding positive regulation of interleukin-1 biosynthetic process positive regulation of interleukin-13 biosynthetic process positive regulation of interleukin-6 biosynthetic process response to ethanol mast cell activation positive regulation of lymphocyte proliferation regulation of inflammatory response positive regulation of peptidyl-tyrosine phosphorylation positive regulation of sequence-specific DNA binding transcription factor activity regulation of sensory perception of pain response to fatty acid