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Rockland
TLR5 Polyclonal Antibody
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TLR5 Antibody (200-401-I28) in IHC (P)
Immunohistochemistry of Rabbit Anti-TLR5 antibody. Tissue: stomach tumor. Fixation: formalin fixed paraffin embedded. Antigen retrieval: not required. Primary antibody: TLR5 antibody at 10 µg/mL for 1 hr at RT. Secondary antibody: Peroxidase rabbit secondary antibody at 1:10,000 for 45 min at RT. Localization: TLR5 is a single-pass type 1 membrane protein. Staining: TLR5 as a precipitated red signal with he... View More
产品信息
200-401-I28
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
TLR5 Antibody was produced from whole rabbit serum prepared by repeated immunizations with a KLH-conjugated peptide corresponding to internal amino acids on human TLR5 protein.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.2
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
TLR5 is a Type I membrane protein belonging to the Toll-like receptor family, participates in the innate immune response to microbial agents. TLR5 also plays a role in mediating detection of bacterial flagellins. TLR5 acts via MyD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. TLR5 protein binds to TIRAP and MyD88 via their respective TIR domains TLR5 is highly expressed in liver, and is detected in lung and at very low levels in most other tissues. The TLR5 gene lies in a locus that is associated with susceptibility to Salmonella. Inbred strains of mice can be classified into 3 categories according to their resistance to infection with S.typhimurium: susceptible (BALB/c, C57BL/6, C3H/He), intermediate (DBA/2, C75L) and resistant (A, CBA). The strain MOLF/Ei is highly susceptible to the infection, has a unique TLR5 haplotype and a lower expression of TRL5. A common TLR5 stop codon polymorphism that disrupts TLR5 signaling is associated with susceptibility to Legionnaires' disease and demonstrates the importance of TLR5 in the innate immune response.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FLJ10052; MGC126430; MGC126431; RP11-239E10.1; systemic lupus erythematosus susceptibility 1; Toll-like receptor 5; Toll/interleukin-1 receptor-like protein 3
基因别名: MELIOS; SLE1; SLEB1; TIL3; TLR5
UniProt ID: (Human) O60602, (Mouse) Q9JLF7
Entrez Gene ID: (Human) 7100, (Mouse) 53791, (Rat) 289337
positive regulation of cytokine production
immune system process
MyD88-dependent toll-like receptor signaling pathway
inflammatory response
signal transduction
positive regulation of interleukin-8 production
positive regulation of toll-like receptor signaling pathway
toll-like receptor 5 signaling pathway
defense response to bacterium
innate immune response
positive regulation of nitric oxide biosynthetic process
regulation of cytokine secretion
male gonad development
cellular response to lipopolysaccharide
cellular response to mechanical stimulus
defense response to Gram-negative bacterium
