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Invitrogen
TLX1 Polyclonal Antibody
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TLX1 Antibody (PA5-88816) in WB
Western blot analysis of TLX1 in extracts of various cell lines. Samples were incubated with TLX1 Polyclonal antibody (Product # PA5-88816) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
产品信息
PA5-88816
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human TLX1 (NP_0011824461)
偶联物
形式
Liquid
浓度
0.46 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: MEHLGPHHLH PGHAEPISFG IDQILNSPDQ GGCMGPASRL QDGEYGLGCL VGGAYTYGGG GSAAATGAGG AGAYGTGGPG GPGGPAGGGG ACSMGPLTGS YNVNMALAGG PGPGGGGGSS GGAGALSAAG VIRVPAHRPL AGAVAHPQPL ATGLPTVPSV PAMPGVNNLT GLTFPWMESN RRYTKDRFTG; Positive Samples: Jurkat, K562, Mouse spleen, Rat spleen; Cellular Location: Nucleus
靶标信息
The Hox proteins play a role in patterns of embryonic development and cellular differentiation by regulating downstream target genes. TLX1, also called homeobox11 (HOX11), as it is located outside of the four mammalian Hox clusters, is a DNA-binding nuclear transcription factor. TLX1 encodes a homeobox-domain containing protein and is containing a glycine and proline-rich amino terminus. TLX1 is required for maintenance of the developing spleen and cell survival. TLX1 is highly expressed in T-cell leukemia and lymphoid neoplasias as a result of translocation. TLX1-deficient mice have no spleen.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: homeo box-11 (T-cell leukemia-3 associated breakpoint, homologous to Drosophila Notch); Homeobox protein Hox-11; homeobox TLX-1; MGC163402; Proto-oncogene TCL-3; T-cell leukemia homeobox protein 1; T-cell leukemia, homeobox 1; T-cell leukemia/lymphoma protein 3
基因别名: Hox-11; HOX11; RGD1563655; TCL3; TLX1
UniProt ID: (Human) P31314
Entrez Gene ID: (Human) 3195, (Rat) 499361, (Mouse) 21908
transcription from RNA polymerase II promoter
multicellular organism development
positive regulation of transcription from RNA polymerase II promoter
central nervous system development
biological_process
positive regulation of cell proliferation
neuron differentiation
cell fate commitment
spleen development
organ formation
lymph node development
