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Invitrogen
TMEFF1 Polyclonal Antibody
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TMEFF1 Antibody (PA5-47998) in IHC (F)
Immunohistochemical analysis of TMEFF1 in perfusion fixed frozen sections of mouse spinal cord. Samples were incubated in TMEFF1 polyclonal antibody (Product # PA5-47998) using a dilution of 15 µg/mL overnight at 4 °C. Tissue was stained with the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown) and counterstained with hematoxylin (blue).
产品信息
PA5-47998
产品规格
种属反应
Mouse
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Mouse myeloma cell line NS0-derived recombinant mouse TMEFF1/Tomoregulin-1 Ser37-Thr320
偶联物
形式
Lyophilized
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
In direct ELISAs and Western blots, approximately 40% cross-reactivity with recombinant human (rh) TMEFF1 is observed and less than 5% cross-reactivity with rhTMEFF2 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
靶标信息
The TMEFF1 gene encodes the protein transmembrane protein with ependymin domain 1, which is involved in cellular signaling and neural development. TMEFF1, characterized by its transmembrane and ependymin-related domains, plays a role in the modulation of cell-cell interactions and signaling pathways essential for brain development and function. This protein is expressed predominantly in the central nervous system, where it influences neuronal differentiation and synaptic formation, contributing to the establishment and maintenance of neural circuits. TMEFF1 has been implicated in neuroprotective functions, where it supports neuronal survival in response to stress or injury. Additionally, its expression has been studied in the context of cancer biology, particularly in brain tumors, where TMEFF1 might impact tumor growth and progression through its effects on cell signaling and adhesion. Research continues to explore the specific mechanisms and interactions of TMEFF1 to better understand its roles in neural health and disease, particularly in neurodevelopmental disorders and cancer.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: H7365member 1; M7365; Tomoregulin-1; TR-1; Transmembrane protein with EGF-like and one follistatin-like domain
基因别名: A830033E11; M7365; Tmeff1; Tr1
UniProt ID: (Mouse) Q6PFE7
Entrez Gene ID: (Mouse) 230157
