Invitrogen

TMEM108 Polyclonal Antibody

Name: TMEM108 Polyclonal Antibody
Brand: Invitrogen
SKU: PA5-85485

查看其他3个TMEM108抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (1)

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TMEM108 Antibody (PA5-85485) in WB

TMEM108 Polyclonal Antibody detects TMEM108 protein by western blot analysis. Whole cell extracts (30 µg) was separated by 10% SDS-PAGE, and the membrane was blotted with TMEM108 Polyclonal Antibody (Product # PA5-85485) diluted by 1:1600.

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产品信息

PA5-85485

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:3,000

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein encompassing a sequence within the center region of human TMEM108. The exact sequence is proprietary.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.8 mg/mL

纯化类型

Antigen affinity chromatography

保存液

0.1M tris glycine, pH 7, with 20% glycerol

内含物

0.01% thimerosal

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_2792625

产品详细信息

Keep as concentrated solution.

Predicted reactivity: Rhesus Monkey (92%).

Positive Control: SH-SY5Y.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

Transmembrane protein 108 (TMEM108) is a gene associated with psychiatric disorders such as schizophrenia, bipolar disorder, and major depression disorder. It is specifically expressed in the nervous system, particularly enriched in the postsynaptic density fraction and DG granule neurons. Research has shown that TMEM108 is critical for adult neurogenesis in the hippocampal dentate gyrus, indicating its role in neuronal development and function. Studies with TMEM108 mutant mice exhibit mania-like behavior, highlighting its involvement in the pathology of bipolar disorder. The gene's expression is notably higher in oligodendrocyte lineage cells within the central nervous system compared to other lineage cells. As a schizophrenia susceptibility gene, TMEM108 has been identified as a potential target for understanding the underlying mechanisms of psychiatric diseases and for developing therapeutic approaches. However, the detailed pathophysiological mechanisms by which TMEM108 contributes to such disorders remain largely unknown.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

仅用于科研。不用于诊断过程。未经明确授权不得转售。