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Invitrogen
TMEM59 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-140175
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.05 mg/mL
规格
5 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.
Immunogen sequence: HLLFPLTLVR SFWSDMMDSA QSFITSSWTF YLQADDGKIV IFQSKPEIQY APHLEQEPTN LRESSLSKMS SDLQMRNSQA HRNFLEDGES DGFLRCLSLN SGW
Highest antigen sequence indentity to the following orthologs: Mouse - 94%, Rat - 92%.
靶标信息
Processing of the amyloid precursor protein (APP) by two different proteases, called alpha- and beta-secretase, is a central regulatory event in the generation of the amyloid beta peptide (Abeta), which has a key role in Alzheimer disease (AD) pathogenesis. TMEM59, a Golgi-localized protein, modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. It inhibits APP transport and shedding.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Liver membrane-bound protein; RP4-758J24.2; Transmembrane protein 59
基因别名: C1orf8; HSPC001; TMEM59; UNQ169/PRO195
Entrez Gene ID: (Human) 9528
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