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Invitrogen
TMEM94 Polyclonal Antibody
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产品信息
PA5-52558
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein corresponding to Human FRMPD4. Recombinant protein control fragment (Product #RP-102448).
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: PETVLFFSGK VEPPHSSHED LTDGLSTRSF CHPEPHERDA LLAGSLNNTL HLSNEQERGD WPGEAPKPPE PYSHHKAHGR SKHPSGSNTQ PGMESDPYEA EDFVCDYHLE ML
Highest antigen sequence identity to the following orthologs: Mouse - 75%, Rat - 79%.
靶标信息
TMEM94, also referred to as ERMA, is a multi-pass transmembrane protein located in the endoplasmic reticulum (ER). It plays a crucial role as a P-type ATPase transporter for Mg2+ ions, featuring large cytosolic domains, including actuator, nucleotide, and phosphorylation sections. This gene is vital for embryonic development, particularly for neurological, craniofacial, and cardiac development, as evidenced by studies involving CRISPR-Cas9 deletion in mice, which resulted in impaired neuro and cardiovascular development. Conventional and AlphaFold2 predictions have reinforced the structural complexity of TMEM94, highlighting its significance in cellular magnesium transport and developmental processes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Endoplasmic reticulum magnesium ATPase; Transmembrane protein 94
基因别名: ERMA; KIAA0195; TMEM94
UniProt ID: (Human) Q12767
Entrez Gene ID: (Human) 9772
