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Invitrogen
TNF alpha Monoclonal Antibody (CC327)
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TNF alpha Antibody (MA5-28512) in Flow
Flow cytometry of TNF alpha in peripheral blood mononuclear cells. Samples were incubated with TNF alpha monoclonal antibody (Product # MA5-28512). Image details are as follows: Upper histogram) the total proportion of CD4+ cells staining for expression of IFN-gamma, IL-2 or TNF-alpha following stimulation with PPD-B (left panel) or medium control (right panel). Subgating of the IFN-gamma+ and IFN-gamma− CD4+ cells provides histograms that represent all possible functionalities for the expressing of the 3 cytokines, as shown in the lower h... View More
产品信息
MA5-28512
产品规格
种属反应
Bovine
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
CC327
抗原
Recombinant bovine TNF alpha
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
TNF alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophage and bind to its receptors, TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF alpha is involved in the regulation of immune cells, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS-PAGE under non-reducing conditions. Knockout studies in mice also suggested the neuroprotective function of TNF alpha, and has been observed to causes tumor necrosis when injected into tumor-bearing mice. Other functions of TNF-alpha include its role in the immune response to bacterial, viral, parasitic and certain fungal infections, as well as its role in the necrosis of specific tumors. TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon-gamma in its cytotoxicity. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cachectin; DADB-70P7.1; TNF alpha; TNF superfamily; TNF α; TNF-a; TNF-alpha; TNFα; Tumor necrosis factor; tumor necrosis factor alpha; Tumor necrosis factor ligand superfamily member 2
基因别名: TNF; TNF-a; TNF-alpha; TNFA; TNFSF2
UniProt ID: (Bovine) Q06599
Entrez Gene ID: (Bovine) 280943
positive regulation of protein phosphorylation
production of molecular mediator involved in inflammatory response
immune response
vascular endothelial growth factor production
positive regulation of plasminogen activation
positive regulation of apoptotic process
negative regulation of protein complex disassembly
positive regulation of protein complex disassembly
positive regulation of MAP kinase activity
positive regulation of JUN kinase activity
positive regulation of inflammatory response
positive regulation of NF-kappaB transcription factor activity
positive regulation of triglyceride metabolic process
necroptotic signaling pathway
negative regulation of lactation
negative regulation of feeding behavior
